Saki Ito
Mayo Clinic
Internal medicineSurgeryArtificial intelligenceCardiologyRetrospective cohort studyHazard ratioAortic valve replacementAsymptomaticMedian follow-upvalvular heart diseaseStenosisValve replacementRegurgitation (circulation)Aortic valve stenosisAortic valve areaRight ventricular dysfunctionIn patientTranscatheter aorticRisk stratificationConfidence intervalMedicineEjection fractionStroke volume
24Publications
4H-index
117Citations
Publications 22
Newest
#1Michal Cohen-Shelly (Mayo Clinic)H-Index: 1
#2Zachi I. Attia (Mayo Clinic)H-Index: 12
Last. Jae K. Oh (Mayo Clinic)H-Index: 119
view all 14 authors...
Aims Early detection of aortic stenosis (AS) is becoming increasingly important with a better outcome after aortic valve replacement in asymptomatic severe AS patients and a poor outcome in moderate AS. We aimed to develop artificial intelligence-enabled electrocardiogram (AI-ECG) using a convolutional neural network to identify patients with moderate to severe AS. Methods and results Between 1989 and 2019, 258 607 adults [mean age 63 ± 16.3 years; women 122 790 (48%)] with an echocardiography a...
10 CitationsSource
#1Nicolas M. Van Mieghem (EUR: Erasmus University Rotterdam)H-Index: 59
#2Stephan Windecker (University of Bern)H-Index: 150
Last. Ariel Finkelstein (Tel Aviv Sourasky Medical Center)H-Index: 18
view all 13 authors...
Objectives null The Evolut R FORWARD study confirmed safety and effectivenesss of the Evolut R THV in routine clinical practice out to 1 year. Herein, we report the final 3-year clinical follow up of the FORWARD study. null Background null Transcatheter aortic valve replacement (TAVR) is a proven alternative to surgery in elderly patients with symptomatic severe aortic stenosis. Long-term clinical outcome data with the Evolut R platform are scarce. null Methods null FORWARD is a prospective mult...
Source
#1Saki Ito (Mayo Clinic)H-Index: 4
#2William R. MirandaH-Index: 14
Last. Jae K. OhH-Index: 119
view all 10 authors...
BACKGROUND Currently risk stratification of moderate aortic stenosis (AS) is still incipient. The aim of this study was to identify prognostic factors in patients with moderate AS. METHODS The prognosis of patients with moderate AS (1 < aortic valve area ≤ 1.5 cm2) stratified by left ventricular ejection fraction (LVEF; 50%), stroke volume index (SVI; 35 mL/m2), and elevated E/e' ratio (average, 14) was compared with that of the age- and sex-matched general population. RESULTS Of 696 patients (m...
5 CitationsSource
#1Saki Ito (Mayo Clinic)H-Index: 4
#2William R. Miranda (Mayo Clinic)H-Index: 14
Last. Jae K. Oh (Mayo Clinic)H-Index: 119
view all 4 authors...
ABSTRACT Plasma B-type natriuretic peptide (BNP) and its N-terminal pro-form, NT-proBNP, can predict outcomes in patients with severe aortic stenosis (AS). However, prognostic value in moderate AS is currently unknown. The present study included 261 patients who diagnosed with moderate AS (1.0 2 ) in 2012 with serum NT-pro BNP level collected within ±3 months of the echocardiographic assessment. Patients were divided into two groups according to the median NT-proBNP value (888 pg/dl) and all-cau...
2 CitationsSource
#1Dan Zhu (PKU: Peking University)H-Index: 1
#2Saki Ito (Mayo Clinic)H-Index: 4
Last. Jae K. Oh (Mayo Clinic)H-Index: 119
view all 9 authors...
BACKGROUND: Left ventricular global longitudinal strain (GLS) is associated with long-term outcomes of patients with severe aortic stenosis. However, its prognostic value in patients with moderate aortic stenosis remains unknown. METHODS: Patients diagnosed with moderate aortic stenosis (1.0 /=50% were identified. GLS was assessed by 2-dimensional strain imaging using speckle-tracking method. All-cause mortality was assessed according to the median GLS value. RESULTS: Two hundred eighty-seven pa...
10 CitationsSource
#1Michal Shelly (Mayo Clinic)
#2Zachi I. Attia (Mayo Clinic)H-Index: 12
Last. Jae K. Oh (Mayo Clinic)H-Index: 119
view all 10 authors...
Patients with moderate to severe aortic stenosis (AS) have increased mortality even when asymptomatic. We hypothesized, that artificial intelligence - (AI) enabled electrocardiogram (ECG) - an inexpensive, ubiquitous, 10 second test - could detect patients with moderate/severe AS. 263,570 Patients
Source
#1Jae K. Oh (Mayo Clinic)H-Index: 119
#2Saki Ito (Mayo Clinic)H-Index: 4
2 CitationsSource
#1Saki Ito (Mayo Clinic)H-Index: 4
#2Cristina Pislaru (Mayo Clinic)H-Index: 17
Last. Jae K. Oh (Mayo Clinic)H-Index: 119
view all 10 authors...
Abstract Objectives This study sought to determine the prevalence of reduced contractility and uncompensated wall stress in patients with aortic stenosis (AS) with preserved or reduced left ventricular ejection fraction (LVEF) and their impact on survival. Background LVEF in AS is determined not only by contractility but also by loading conditions. Methods Patients with first diagnosis (time 0) of severe AS (aortic valve area, [AVA]≤1 cm2) with prior echo study (-3±1 years) were identified. Cont...
14 CitationsSource
#1Saki Ito (Mayo Clinic)H-Index: 4
#2Vuyisile T. Nkomo (Mayo Clinic)H-Index: 34
Last. Jae K. Oh (Mayo Clinic)H-Index: 119
view all 15 authors...
Abstract Objective To assess the impact of stroke volume index (SVI) and left ventricular ejection fraction (LVEF) on prognosis in patients with severe aortic stenosis, comparing those undergoing transcatheter aortic valve replacement (TAVR) and those with surgical AVR (SAVR). Patients and Methods A total of 742 patients from the CoreValve US Pivotal High-Risk Trial randomized to TAVR (n=389) or SAVR (n=353) from February 2011 to September 2012 were stratified by an SVI of 35 mL/m2 and LVEF of 5...
2 CitationsSource
#1Saki Ito (Mayo Clinic)H-Index: 4
#2William R. Miranda (Mayo Clinic)H-Index: 14
Last. J.K. Oh (Mayo Clinic)H-Index: 4
view all 9 authors...
Source