Antonella Bordin
Sapienza University of Rome
Clonogenic assayEndothelial stem cellStromal cellAdipose tissueMesenchymal stem cellProgenitor cellImmunologyOxidative stressPlatelet lysateStem-cell therapyAngiogenesisPopulationEpigeneticsSenescenceOxidative phosphorylationTransdifferentiationHistoneMedicineBiologyCell biology
14Publications
8H-index
237Citations
Publications 14
Newest
#1Giacomo Frati (Sapienza University of Rome)H-Index: 47
#2Maurizio ForteH-Index: 22
Last. Sebastiano Sciarretta (Sapienza University of Rome)H-Index: 38
view all 22 authors...
Background The role of microRNAs dysregulation in tobacco cigarette smoking–induced vascular damage still needs to be clarified. We assessed the acute effects of tobacco cigarette smoking on endoth...
1 CitationsSource
#1Carmela Rita Balistreri (University of Palermo)H-Index: 31
#2Elena De Falco (Sapienza University of Rome)H-Index: 19
Last. Alexander VaisermanH-Index: 27
view all 6 authors...
Stem cell therapy (SCT), born as therapeutic revolution to replace pharmacological treatments, remains a hope and not yet an effective solution. Accordingly, stem cells cannot be conceivable as a “canonical” drug, because of their unique biological properties. A new reorientation in this field is emerging, based on a better understanding of stem cell biology and use of cutting-edge technologies and innovative disciplines. This will permit to solve the gaps, failures, and long-term needs, such as...
4 CitationsSource
#1Eleonora Scaccia (Sapienza University of Rome)H-Index: 2
#2Antonella Bordin (Sapienza University of Rome)H-Index: 8
Last. Elena De Falco (Sapienza University of Rome)H-Index: 19
view all 4 authors...
Abstract Although controlling a wide range of physiological cell functions, redox states unbalance during inflammation toward oxidative stress. Specific regions of our genome are extremely sensitive to both oxygen and reactive oxygen species, therefore modulating gene transcription in response to this specific epigenetic effect. Additional epigenetic mechanisms may include the alteration of the methylation states of DNA, protein and lipid nitration or modulation of specific microRNAs. A crucial ...
Source
#1Antonella Bordin (Sapienza University of Rome)H-Index: 8
#2Francesca Pagano (Sapienza University of Rome)H-Index: 13
Last. Elena De Falco (Sapienza University of Rome)H-Index: 19
view all 10 authors...
Type 2 diabetes (T2D) is a major metabolic disease and a key epigenetic risk factor for the development of additional clinical complications. Among them, periodontitis (PD), a severe inflammatory disease ascribable to a dysregulated physiology and composition of the oral microbiota, represents one of the most relevant complications. Periodontitis can impact the structure of the tooth and likely the stem and progenitor cell pool, which actively contributes to the periodontal microenvironment and ...
2 CitationsSource
#1Rita Businaro (Sapienza University of Rome)H-Index: 6
#1Rita Businaro (Sapienza University of Rome)H-Index: 18
Last. Elena De Falco (Sapienza University of Rome)H-Index: 19
view all 14 authors...
Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets, which are source of clinical hemoderivates, such as platelet lysate (PL), routinely employed in several clinical applications as wound healing, and to preserve ex vivo the progenitor properties of the adipose stromal cells pool. So far, the pres...
8 CitationsSource
#1Francesco Angelini (Sapienza University of Rome)H-Index: 14
#2Francesca Pagano (Sapienza University of Rome)H-Index: 13
Last. Isotta Chimenti (Sapienza University of Rome)H-Index: 22
view all 6 authors...
Global aging is a hallmark of our century. The natural multifactorial process resulting in aging involves structural and functional changes, affecting molecules, cells, and tissues. As the western population is getting older, we are witnessing an increase in the burden of cardiovascular events, some of which are known to be directly linked to cellular senescence and dysfunction. In this review, we will focus on the description of a few circulating molecules, which have been correlated to lifespa...
11 CitationsSource
#1Elena De Falco (Sapienza University of Rome)H-Index: 19
#2Antonella Bordin (Sapienza University of Rome)H-Index: 8
Last. Giacomo Frati (Sapienza University of Rome)H-Index: 47
view all 13 authors...
Abstract Background Although adipose stromal cells (ASCs) retain the ability to transdifferentiate at low rate towards the cardiac lineage, the potential mechanisms underlying such process have still to be elucidated. Methods Since chromatin state modifications are involved in several processes regulating the cellular cell fate commitment, we aimed at evaluating the role of histone protein acetylation in the cardiovascular-like transdifferentiation of ASCs. Results We found a clear increase of h...
2 CitationsSource
#1Leonardo Schirone (Sapienza University of Rome)H-Index: 7
#2Maurizio ForteH-Index: 22
Last. Giacomo Frati (Sapienza University of Rome)H-Index: 47
view all 16 authors...
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction. Among the complex signaling network that characterizes myocardial remodeling, the distinct processes are myocyte loss, cardiac hypertrophy, alteration of extracellular matrix homeostasis, fibrosis, defective autophagy, metabolic abnormalities, and mitochondrial dysfunction. Several pathophysiological stimuli, such as pressure and volume over...
133 CitationsSource
#1Francesco Angelini (Sapienza University of Rome)H-Index: 14
#2Francesca Pagano (Sapienza University of Rome)H-Index: 13
Last. Elena De Falco (Sapienza University of Rome)H-Index: 19
view all 14 authors...
Oxidative states exert a significant influence on a wide range of biological and molecular processes and functions. When their balance is shifted towards enhanced amounts of free radicals, pathological phenomena can occur, as the generation of reactive oxygen species (ROS) in tissue microenvironment or in the systemic circulation can be detrimental. Epidemic chronic diseases of western societies, such as cardiovascular disease, obesity, and diabetes correlate with the imbalance of redox homeosta...
19 CitationsSource
#1Elena De Falco (Sapienza University of Rome)H-Index: 19
#2Roberto Carnevale (Sapienza University of Rome)H-Index: 36
Last. Giacomo Frati (Sapienza University of Rome)H-Index: 47
view all 15 authors...
Abstract Senescence exerts a great impact on both biological and functional properties of circulating endothelial progenitor cells (EPCs), especially in cardiovascular diseases where the physiological process of aging is accelerated upon clinical administration of certain drugs such as doxorubicin. EPC impairment contributes to doxorubicin-induced cardiotoxicity. Doxorubicin accelerates EPC aging, although mechanisms underlying this phenomenon remain to be fully clarified. Here we investigated i...
24 CitationsSource