Christine L. Hammond
University of Rochester
Internal medicineEndocrinologyTransporterReceptorChemistryApoptosisEffluxCholesterolTransforming growth factor betaGlutathione disulfideBile acidExtracellularAryl hydrocarbon receptorMultidrug resistance-associated protein 2Cancer researchGlutathioneBiochemistryIntracellularBiologyCell biology
19Publications
12H-index
1,706Citations
Publications 21
Newest
#1Vardaan Gupta (UR: University of Rochester)
#2Christine L. Hammond (UR: University of Rochester)H-Index: 12
Last. Collynn F. Woeller (UR: University of Rochester)H-Index: 20
view all 6 authors...
Abstract null null Thyroid eye disease (TED) is an autoimmune disorder that manifests in the orbit. In TED, the connective tissue behind the eye becomes inflamed and remodels with increased fat accumulation and/or increased muscle and scar tissue. As orbital tissue expands, patients develop edema, exophthalmos, diplopia, and optic neuropathy. In severe cases, vision loss may occur secondary to corneal scarring from exposure or optic nerve compression. Currently there is no cure for TED, and trea...
Source
#1Christine L. Hammond (UR: University of Rochester)H-Index: 12
#2Elisa Roztocil (UR: University of Rochester)H-Index: 16
Last. Collynn F. Woeller (UR: University of Rochester)H-Index: 20
view all 5 authors...
Purpose Thyroid eye disease (TED) is a condition that causes the tissue behind the eye to become inflamed and can result in excessive fatty tissue accumulation in the orbit. Two subpopulations of fibroblasts reside in the orbit: those that highly express Thy1 (Thy1+) and those with little or no Thy1 (Thy1-). Thy1- orbital fibroblasts (OFs) are more prone to lipid accumulation than Thy1+ OFs. The purpose of this study was to investigate the mechanisms whereby Thy1- OFs more readily accumulate lip...
Source
#1Collynn F. Woeller (UR: University of Rochester)H-Index: 20
#2Elisa Roztocil (UR: University of Rochester)H-Index: 16
Last. Steven E. Feldon (UR: University of Rochester)H-Index: 46
view all 4 authors...
#1Elisa Roztocil (UR: University of Rochester)H-Index: 16
#2Christine L. Hammond (UR: University of Rochester)H-Index: 12
Last. Collynn F. Woeller (UR: University of Rochester)H-Index: 20
view all 5 authors...
Thyroid eye disease (TED) affects 25–50% of patients with Graves’ Disease. In TED, collagen accumulation leads to an expansion of the extracellular matrix (ECM) which causes destructive tissue remodeling. The purpose of this study was to investigate the therapeutic potential of activating the aryl hydrocarbon receptor (AHR) to limit ECM accumulation in vitro. The ability of AHR to control expression of matrix metalloproteinase-1 (MMP1) was analyzed. MMP1 degrades collagen to prevent excessive EC...
Source
#1Collynn F. Woeller (UR: University of Rochester)H-Index: 20
#2Elisa Roztocil (UR: University of Rochester)H-Index: 16
Last. Steven E. Feldon (UR: University of Rochester)H-Index: 46
view all 4 authors...
Purpose: To investigate the molecular pathways that drive thyroid stimulating hormone receptor (TSHR)-induced cellular proliferation in orbital fibroblasts (OFs) from thyroid eye disease (TED) patients. Methods: Orbital fibroblasts from TED and non-TED patients were treated with TSH and changes in gene expression and proliferation were measured. To determine the role of TSHR, TSHR-specific siRNA was used to deplete TSHR levels. Proliferation was measured by bromodeoxyuridine (BrdU) incorporation...
Source
#1Christine L. Hammond (UR: University of Rochester)H-Index: 12
#2Elisa Roztocil (UR: University of Rochester)H-Index: 16
Last. Collynn F. Woeller (UR: University of Rochester)H-Index: 20
view all 5 authors...
Thyroid eye disease (TED) can lead to scar formation and tissue remodeling in the orbital space. In severe cases, the scarring process leads to sight-threatening pathophysiology. There is no known effective way to prevent scar formation in TED patients, or to reverse scarring once it occurs. In this study, we show that the proton pump inhibitors (PPIs), esomeprazole and lansoprazole, can prevent transforming growth factor beta (TGFβ)-mediated differentiation of TED orbital fibroblasts to myofibr...
Source
#1Collynn F. Woeller (UR: University of Rochester)H-Index: 20
#2Elisa Roztocil (UR: University of Rochester)H-Index: 16
Last. Richard P. Phipps (UR: University of Rochester)H-Index: 92
view all 5 authors...
Thyroid eye disease (TED) is a degenerative disease that manifests with detrimental tissue remodeling, myofibroblast accumulation, and scarring in the orbit of affected individuals. Currently, there are no effective therapies for TED that target or prevent the excessive tissue remodeling caused by myofibroblast formation and activation. The canonical cytokine that induces myofibroblast formation is transforming growth factor (TGF)-β. The TGF-β signaling pathway is influenced by aryl hydrocarbon ...
Source
#1Christine L. Hammond (UR: University of Rochester)H-Index: 12
#2Sadie G. Wheeler (UR: University of Rochester)H-Index: 3
Last. Patricia M. Hinkle (UR: University of Rochester)H-Index: 50
view all 4 authors...
Organic solute transportera-OSTb is a bile acid transporter important for bile acid recycling in the enterohepatic circulation. In comparison to wild-type mice, Osta / mice have a lower bile acid pool and increased fecal lipids and they are relatively resistant to age-related weight gain and insulin resistance. These studies tested whether Osta / mice are also protected from weight gain, lipid changes, and insulin resistance which are normally observed with a western-style diet high in both fat ...
Source
#1Sadie G. Wheeler (UR: University of Rochester)H-Index: 3
#2Christine L. Hammond (UR: University of Rochester)H-Index: 12
Last. Nazzareno Ballatori (UR: University of Rochester)H-Index: 56
view all 9 authors...
The organic solute transporter OSTα-OSTβ is a key transporter for the efflux of bile acids across the basolateral membrane of ileocytes and the subsequent return of bile acids to the liver. Ostα−/− mice exhibit reduced bile acid pools and impaired lipid absorption. In this study, wild-type and Ostα−/− mice were characterized at 5 and 12 mo of age. Ostα−/− mice were resistant to age-related weight gain, body fat accumulation, and liver and muscle lipid accumulation, and male Ostα−/− mice lived sl...
Source
#1Nazzareno Ballatori (UR: University of Rochester)H-Index: 56
#2Whitney V. Christian (UR: University of Rochester)H-Index: 9
Last. Christine L. Hammond (UR: University of Rochester)H-Index: 12
view all 4 authors...
The organic solute transporter alpha–beta (OSTα–OSTβ) is one of the newest members of the solute carrier family, designated as SLC51, and arguably one of the most unique. The transporter is composed of two gene products encoded by SLC51A and SLC51B that heterodimerize to form the functional transporter complex. SLC51A encodes OSTα, a predicted 340-amino acid, 7-transmembrane (TM) domain protein, whereas SLC51B encodes OSTβ, a putative 128-amino acid, single-TM domain polypeptide. Heterodimerizat...
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