Luca Morelli
University of Pisa
Robotic surgeryCancerInternal medicineRadiologySurgeryPathologyOncologyPancreas transplantationPancreasLaparoscopySingle CenterPancreatic cancerTransplantationRectal resectionTable (database)Cancer researchGeneral surgeryMedicineBiologyGastroenterology
Publications 345
#1T.Y.S. Le LargeH-Index: 3
#2Maarten F. Bijlsma (UvA: University of Amsterdam)H-Index: 19
Last. Elisa Giovannetti (UvA: University of Amsterdam)H-Index: 60
view all 17 authors...
Background Pancreatic ductal adenocarcinoma (PDAC) is a very lethal disease, with minimal therapeutic options. Aberrant tyrosine kinase activity influences tumor growth and is regulated by phosphorylation. We investigated phosphorylated kinases as target in PDAC. Methods Mass spectrometry-based phosphotyrosine proteomic analysis on PDAC cell lines was used to evaluate active kinases. Pathway analysis and inferred kinase activity analysis was performed to identify novel targets. Subsequently, we ...
#1Matteo PalmeriH-Index: 13
#2Andrea PeriH-Index: 11
Last. Luca MorelliH-Index: 22
view all 10 authors...
#1Gregorio Di Franco (UniPi: University of Pisa)H-Index: 13
#2Valentina Lorenzoni (Sant'Anna School of Advanced Studies)H-Index: 23
Last. Luca Morelli (UniPi: University of Pisa)H-Index: 22
view all 14 authors...
Robot-assisted pancreatoduodenectomy (RPD) has shown some advantages over open pancreatoduodenectomy (OPD) but few studies have reported a cost analysis between the two techniques. We conducted a structured cost-analysis comparing pancreatoduodenectomy performed with the use of the da Vinci Xi, and the traditional open approach, and considering healthcare direct costs associated with the intervention and the short-term post-operative course. Twenty RPD and 194 OPD performed between January 2011 ...
#1Riccardo CapecchiH-Index: 6
#2Cristina CroiaH-Index: 10
Last. Paola MiglioriniH-Index: 43
view all 10 authors...
BACKGROUND: CXCL12/SDF-1 is a chemokine with pleiotropic functions in hematopoietic stem cells niche homeostasis, germinal centre architecture, B cells maturation, neoangiogenesis and fibrosis. Recently, the CXCL12/CXCR4/CXCR7 axis was associated to cancer metastasis and autoimmune diseases. IgG4-Related Disease (IgG4-RD) is a pathological condition characterized by IgG4+ plasma cells infiltrating fibrotic lesions. Aim of this research was to investigate the relevance of SDF-1/CXCL12 in IgG4-RD....
#1G. Peduzzi (UniPi: University of Pisa)H-Index: 1
#2Manuel Gentiluomo (UniPi: University of Pisa)H-Index: 6
Last. Luca Morelli (UniPi: University of Pisa)H-Index: 22
view all 68 authors...
Background The mitochondrial metabolism has been associated with pancreatic ductal adenocarcinoma (PDAC) risk. Recent evidence also suggests the involvement of the genetic variability of the mitochondrial function in several traits involved in PDAC aetiology. However, a systematic investigation of the genetic variability of mitochondrial genome (mtSNPs) and of all the nuclear genes involved in its functioning (n-mtSNPs) has never been reported. Methods We conducted a two-phase association study ...
Minimally invasive Ivor Lewis esophagectomy (MIILE) provides better outcomes than open techniques, particularly in terms of post-operative recovery and pulmonary complications. However, in addition to requiring advanced technical skills, thoracoscopic access makes it hard to perform esophagogastric anastomosis safely, and the reported rates of anastomotic leak vary from 5 to 16%. Several minimally invasive esophago-gastric anastomotic techniques have been described, but to date strong evidence t...
#6Susanne Roth (Heidelberg University)H-Index: 12
#10Patrícia SarlósH-Index: 19
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