Shigeyoshi Oba
University of Tokyo
Messenger RNAInternal medicineUrologyMicrocirculationDownregulation and upregulationEndocrinologyPathologymicroRNAMolecular biologyProinflammatory cytokineEndogenyAdipose tissueTumor necrosis factor alphaChemistrySmall interfering RNAOxidative stressInflammationPodocyteAdrenomedullinKidney diseaseVascular smooth muscleKidneyStem cellAngiotensin IIRenal glomerulusCancer researchSignal transductionMedicineParacrine signallingBlood pressureBiologyCell biology
35Publications
14H-index
660Citations
Publications 35
Newest
#1Daigoro Hirohama (UTokyo: University of Tokyo)H-Index: 11
#2Mitsuhiro Nishimoto (UTokyo: University of Tokyo)H-Index: 9
Last. Toshiro Fujita (UTokyo: University of Tokyo)H-Index: 121
view all 9 authors...
The progression of diabetic kidney disease (DKD), a leading cause of end-stage kidney disease, involves mineralocorticoid receptor (MR) activation. We previously identified crosstalk between the small guanosine triphosphatase (GTPase) RAS-related C3 botulinus toxin substrate 1 (Rac1) and MR, but the role of Rac1-MR pathway activation in the progression of DKD is not clear. We performed uninephrectomy on type 2 diabetic mouse models, db/db (UNx-high salt [HS] db/db), and their lean control, db/m ...
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#1Wakako Kawarazaki (UTokyo: University of Tokyo)H-Index: 11
#2Risuke Mizuno (UTokyo: University of Tokyo)H-Index: 14
Last. Toshiro Fujita (UTokyo: University of Tokyo)H-Index: 121
view all 10 authors...
Aging is associated with a high prevalence of hypertension due to elevated susceptibility of BP to dietary salt, but its mechanism is unknown. Serum levels of Klotho, an anti-aging factor, decline with age. We found that high salt (HS) increased BP in aged mice and young heterozygous Klotho-knockout mice and was associated with increased vascular expression of Wnt5a and p-MYPT1, which indicate RhoA activity. Not only the Wnt inhibitor LGK974 and the Wnt5a antagonist Box5 but Klotho supplementati...
9 CitationsSource
#1Hiroyuki Imuta (UTokyo: University of Tokyo)H-Index: 11
#2Daishi Fujita (UTokyo: University of Tokyo)H-Index: 18
Last. Etsu Suzuki (St. Marianna University School of Medicine)H-Index: 33
view all 7 authors...
Macrophages play a crucial role in the development of atherosclerosis. To explore the mechanism by which macrophages attain a proinflammatory phenotype for a sustained period, we stimulated macrophages with lipopolysaccharide (LPS) and interferon-γ (IFN-γ) and measured the interleukin-1β (IL-1β) expression. The IL-1β expression increased transiently, and its expression lasted for, at least, 1 week after the cessation of LPS and IFN-γ stimulation. At the promoter region of the IL-1β gene, the dem...
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#1Mitsuhiro Nishimoto (UTokyo: University of Tokyo)H-Index: 9
#2Hiroshi OhtsuH-Index: 12
Last. Toshiro Fujita (UTokyo: University of Tokyo)H-Index: 121
view all 14 authors...
Excessive dietary salt intake can counteract the renoprotective effects of renin–angiotensin system (RAS) blockade in hypertensive patients with chronic kidney disease (CKD). In rodents, salt loading induces hypertension and renal damage by activating the mineralocorticoid receptor (MR) independently of plasma aldosterone levels. Thus, high salt-induced resistance to RAS blockade may be mediated by MR activation. To test this, a post hoc analysis of the Eplerenone Combination Versus Conventional...
12 CitationsSource
#1Shigeyoshi Oba (UTokyo: University of Tokyo)H-Index: 14
#2Nobuhiro Ayuzawa (UTokyo: University of Tokyo)H-Index: 11
Last. Toshiro Fujita (UTokyo: University of Tokyo)H-Index: 121
view all 10 authors...
Epigenetic modulation may underlie the progression of diabetic nephropathy (DN). Involvement of TGFB1 in mesangial fibrosis of DN led us to hypothesize that Tgfb1 DNA demethylation contributes to progression of DN. In primary mesangial cells from diabetic (db/db) mouse kidneys, demethylation of Tgfb1 DNA and upregulation of Tgfb1 mRNA progressed simultaneously. USF1 binding site in Tgfb1 promoter region were demethylated, and binding of USF1 increased, with decreased binding of DNMT1 in db/db co...
11 CitationsSource
#1Fumiko Kawakami-Mori (UTokyo: University of Tokyo)H-Index: 9
#2Mitsuhiro Nishimoto (UTokyo: University of Tokyo)H-Index: 9
Last. Toshiro FujitaH-Index: 121
view all 12 authors...
: Maternal malnutrition, which causes prenatal exposure to excessive glucocorticoid, induces adverse metabolic programming, leading to hypertension in offspring. In offspring of pregnant rats receiving a low-protein diet or dexamethasone, a synthetic glucocorticoid, mRNA expression of angiotensin receptor type 1a (Agtr1a) in the paraventricular nucleus (PVN) of the hypothalamus was upregulated, concurrent with reduced expression of DNA methyltransferase 3a (Dnmt3a), reduced binding of DNMT3a to ...
11 CitationsSource
#1Etsu Suzuki (St. Marianna University School of Medicine)H-Index: 33
#2Hiroyuki Imuta (UTokyo: University of Tokyo)H-Index: 11
Last. Hiroaki Nishimatsu (Memorial Hospital of South Bend)H-Index: 4
view all 7 authors...
BACKGROUND: Intraplaque hemorrhage (IPH) has been implicated in plaque instability and rupture in atherosclerotic lesions, although the mechanisms by which IPH progresses remain largely unknown. In this study, apolipoprotein E-deficient mice with carotid artery ligation and cuff placement around the artery were used, and pro-inflammatory cytokines that are implicated in IPH were analyzed.Methods and Results:The expression of interleukin-1β (IL-1β) increased significantly following cuff placement...
1 CitationsSource
#1Etsu Suzuki (St. Marianna University School of Medicine)H-Index: 33
#2Daishi Fujita (UTokyo: University of Tokyo)H-Index: 5
Last. Hiroaki Nishimatsu (UTokyo: University of Tokyo)H-Index: 37
view all 5 authors...
Mesenchymal stem cells (MSCs) are multipotent stem cells that reside in various organs. They have the capacity to differentiate into various cell types, including cardiomyocytes, vascular endothelial cells, and vascular smooth muscle cells. Among the various MSCs, bone marrow-derived MSCs (BMMSCs) have been widely used for treating acute myocardial infarction (AMI) and ischemic heart failure (IHF) in preclinical and clinical studies. Although the beneficial effects of BMMSCs in treating AMI and ...
28 CitationsSource
#1Haruna Yamamoto (Tokai University)H-Index: 2
#2Jun LuH-Index: 145
Last. Ai KotaniH-Index: 16
view all 14 authors...
The Ecotropic viral integration site 1 (Evi1) is a zinc finger transcription factor, which is located on chromosome 3q26, over-expression in some acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Elevated Evi1 expression in AML is associated with unfavorable prognosis. Therefore, Evi1 is one of the strong candidate in molecular target therapy for the leukemia. MicroRNAs (miRNAs) are small non-coding RNAs, vital to many cell functions that negatively regulate gene expression by tra...
19 CitationsSource
#1Tomohiko Sato (UTokyo: University of Tokyo)H-Index: 3
#2Masao Takahashi (UTokyo: University of Tokyo)H-Index: 20
Last. Etsu Suzuki (St. Marianna University School of Medicine)H-Index: 33
view all 7 authors...
BACKGROUND: Although drug-eluting stents (DES) have been widely used for the treatment of coronary artery disease, they potentially increase the risk of late thrombosis. It is, therefore, desirable to establish a strategy to stimulate reendothelialization. Endothelial injury models have been widely used to analyze the mechanisms of coronary restenosis. However, animal models deployed with coronary stents in the blood vessels are necessary to accurately analyze the mechanisms of coronary restenos...
6 CitationsSource