Jan-Ake Gustafsson
University of Houston
CancerEndocrinologyMolecular biologyLiver X receptorReceptorEstrogen receptor alphaChemistryEstrogenCancer researchBiochemistryGlucocorticoid receptorMetabolismNuclear receptorHormoneMedicineEstrogen receptorTranscription factorBiologyCell biologyEstrogen receptor beta
Publications 1623
#1Laura MarroquíH-Index: 23
#2Juan Martinez-Pinna (University of Alicante)H-Index: 14
Last. Angel NadalH-Index: 56
view all 10 authors...
Abstract Bisphenol-S (BPS) and Bisphenol-F (BPF) are current Bisphenol-A (BPA) substitutes. Here we used pancreatic β-cells from wild type (WT) and estrogen receptor β (ERβ) knockout (BERKO) mice to investigate the effects of BPS and BPF on insulin secretion, and the expression and activity of ion channels involved in β-cell function. BPS or BPF rapidly increased insulin release and diminished ATP-sensitive K+ (KATP) channel activity. Similarly, 48 h treatment with BPS or BPF enhanced insulin re...
1 CitationsSource
#1Mukesh VarshneyH-Index: 4
#2Nancy Yiu-Lin YuH-Index: 8
Last. Ivan NalvarteH-Index: 14
view all 13 authors...
Introduction Male estrogen receptor beta (ERbeta) knockout (BERKO) mice display anxiety and aggression linked to, among others, altered serotonergic signaling in the basolateral amygdala and dorsal raphe, impaired cortical radial glia migration and reduced GABAergic signaling. Effects on primary motor cortex (M1 cortex) and locomotor activity as a consequence of ERbeta loss have not been investigated. Objective The aim of this study was to determine whether locomotor activity is altered as a con...
2 CitationsSource
#1Zhengnan Yang (Sichuan University)H-Index: 3
#2Ryan C. Gimple (UCSD: University of California, San Diego)H-Index: 14
Last. Shengtao Zhou (Sichuan University)H-Index: 19
view all 6 authors...
#1Linnea Hases (KTH: Royal Institute of Technology)H-Index: 2
#1Linnea Hases (KTH: Royal Institute of Technology)H-Index: 2
Last. Cecilia Williams (KI: Karolinska Institutet)H-Index: 30
view all 12 authors...
Abstract Estrogen hormones protect against colorectal cancer (CRC) and a preventative role of estrogen receptor beta (ERβ) on CRC has been supported usisng full knockout animals. However, it is unclear through which cells or organ ERβ mediates this effect. To investigate the functional role of intestinal ERβ during colitis-associated CRC we used intestine-specific ERβ knockout mice treated with azoxymethane and dextran sodium sulfate, followed by ex vivo organoid culture to corroborate intrinsic...
4 CitationsSource
#1Surendra Chaurasiya (UH: University of Houston)H-Index: 2
#2Wanfu Wu (UH: University of Houston)H-Index: 8
Last. Jan-Ake Gustafsson (UH: University of Houston)H-Index: 148
view all 5 authors...
Loss of the tumor suppressor, PTEN, is one of the most common findings in prostate cancer (PCa). This loss leads to overactive Akt signaling, which is correlated with increased metastasis and androgen independence. However, another tumor suppressor, inositol-polyphosphate 4-phosphatase type II (INPP4B), can partially compensate for the loss of PTEN. INPP4B is up-regulated by androgens, and this suggests that androgen-deprivation therapy (ADT) would lead to hyperactivity of AKT. However, in the p...
1 CitationsSource
#1Husna KarabogaH-Index: 2
#2Wentao Huang (Guangxi Medical University)
Last. Chin-Yo LinH-Index: 26
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Pancreatic ductal adenocarcinoma (PDAC) is the predominant form of pancreatic cancer. PDACs harbor oncogenic mutations in the KRAS gene, and ongoing efforts to directly target its mutant protein product to inhibit tumor growth are a priority not only in pancreatic cancer but in other malignancies such as lung and colorectal cancers where KRAS is also commonly mutated. An alternative strategy to directly targeting KRAS is to identify and target druggable receptors involved in dysregulated cancer ...
1 CitationsSource
#1Christopher T. Chan (Harvard University)H-Index: 14
#2Ashley M. Fenn (Harvard University)H-Index: 17
Last. Filip K. Swirski (Harvard University)H-Index: 69
view all 25 authors...
The thymus is a primary lymphoid organ necessary for optimal T cell development. Here, we show that liver X receptors (LXRs)-a class of nuclear receptors and transcription factors with diverse functions in metabolism and immunity-critically contribute to thymic integrity and function. LXRαβ-deficient mice develop a fatty, rapidly involuting thymus and acquire a shrunken and prematurely immunoinhibitory peripheral T cell repertoire. LXRαβ's functions are cell specific, and the resulting phenotype...
5 CitationsSource
#1Laura Marroquí (Universidad Miguel Hernández de Elche)H-Index: 23
#2Juan Martinez-Pinna (University of Alicante)H-Index: 14
Last. Angel Nadal (Universidad Miguel Hernández de Elche)H-Index: 56
view all 10 authors...
#1Shuang Huang (Sichuan University)H-Index: 3
#2Nianxin Zhou (Sichuan University)H-Index: 3
Last. Shengtao Zhou (Sichuan University)H-Index: 19
view all 17 authors...
SUMMARY The emerging immune checkpoint blockade (ICB) therapy has ushered the cancer therapeutics field into an era of immunotherapy. While ICB treatment provides remarkable clinical responses in a subset of cancer patients, this regimen fails to extend survival in a large proportion of patients. Here, we found that a combined treatment of estrogen receptor beta (ERβ) agonist and PD-1 antibody treatment improved therapeutic efficacy in mouse tumor models, compared with monotherapies, by reducing...
3 CitationsSource
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