Shaokun Liu
Central South University
PathophysiologyGATA3Messenger RNAAirwayEnvironmental chemistryInterleukin-21 receptorBiological activityGene silencingInterleukin-23 receptorInternal medicineInterleukin 21EndocrinologyCellular differentiationCellMolecular biologyInterleukin 23Proinflammatory cytokineRNA interferenceAndrologyReceptorInterleukin 5ChemistryInterleukin 10ApoptosisInterleukin 4In vitroImmunologyAutophagySmall interfering RNAParticulatesFEV1/FVC ratioAsthmaT cellOxidative stressWestern blotAcute promyelocytic leukemiaCOPDSteroid hormoneInflammationOvalbuminDehydroepiandrosteroneExacerbationMucusLungBronchoalveolar lavageAtrial natriuretic peptideFlutamideCytokineDiseaseAllergic inflammationCHOPAMPKTerbutalineArsenic trioxideDexamethasoneHMGB1Nitrogen dioxideSpleenPathogenesisATG5Systemic inflammatory response syndromeAlanylglutamineAsthma severityBeta-ArrestinsCCL13Air pollutantsLung injuryAsthma phenotypesT lymphocyteAtmospheric exposureß arrestin 2Th17 cytokinesMurine modelInterleukin 17ArsenicCancer researchRespiratory systemGut floraTransfectionMonoclonal antibodyCarcinogenesisAir pollutionMAPK/ERK pathwayAndrogen receptorSignal transductionHomeostasisMedicineProtein kinase BPulmonary function testingEpithelial–mesenchymal transitionIL-2 receptorHazeBlotTranscription factorPI3K/AKT/mTOR pathwayBiologyPharmacology
Publications 17
#2Yu YuanH-Index: 3
Last. Libing MaH-Index: 8
view all 16 authors...
#1Binaya Wasti (CSU: Central South University)H-Index: 3
#2Shaokun Liu (CSU: Central South University)H-Index: 8
Last. Xudong Xiang (CSU: Central South University)H-Index: 18
view all 3 authors...
#1Su-bo Gong (CSU: Central South University)H-Index: 7
#2Xiao-Ying Ji (SYSU: Sun Yat-sen University)H-Index: 2
Last. Shaokun Liu (CSU: Central South University)H-Index: 8
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Background and Purpose. Allergic asthma, a respiratory disease with high morbidity and mortality, is reported to be related to the airway allergic inflammation and autophagy-induced oxidative stress. Although the therapeutic effects of fermentate prebiotic (YFP) on allergic asthma have been widely claimed, the underlying mechanism is still unclear. This study is aimed at investigating the possible mechanism for the antiasthma property of YFP in a mouse model. Methods. Ovalbumin was used to induc...
#1Wenjin Sun (Sichuan University)
#2Yu Yuan (CSU: Central South University)H-Index: 3
Last. Bing Xiao (CSU: Central South University)H-Index: 5
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Asthma is a heterogeneous disease, and abnormal activation of T cells is the driving link of asthma’s pathophysiological changes. Dual-positive Th2–Th17 cells, as newly discovered T-helper cells, have the functions of Th2 and Th17 cells and can coproduce Th2 and Th17 cytokines. Previous studies have shown that dual-positive Th2–Th17 cells increase the chances of asthma and correlate with asthma severity. However, the exact role of dual-positive Th2–Th17 cells in asthma is not known. Since there ...
#1Shaokun Liu (CSU: Central South University)H-Index: 8
#2Libing Ma (GLMU: Guilin Medical University)H-Index: 8
Last. Xudong Xiang (CSU: Central South University)H-Index: 18
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Objective. Allergic asthma is a chronic inflammatory disease, which seriously affects the life quality of patients, especially children. Alanylglutamine is a nutritional supplement with potential protective and anti-inflammatory effects, but its function in allergic asthma remains elusive. In this study, we focused on the investigations of the roles and functional mechanism of Alanylglutamine in asthma. Methods. Ovalbumin (OVA) induction was utilized to establish a mouse asthma model. 16S rDNA s...
#1Shaokun Liu (CSU: Central South University)H-Index: 8
#2Shan Cai (CSU: Central South University)H-Index: 12
Last. Xudong Xiang (CSU: Central South University)H-Index: 18
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Detrimental health effects of atmospheric exposure to ambient particulate matter (PM) have been investigated in numerous studies. Exposure to pollutional haze, the carrier of air pollutants such as PM and nitrogen dioxide (NO 2 ) has been linked to lung and cardiovascular disease, resulting increases in both hospital admissions and mortality. This review focuses on the constituents of pollutional haze and its effects on pulmonary function. The article presents the available information and seeks...
#1Libing MaH-Index: 5
#2Jinrong Zeng (GLMU: Guilin Medical University)H-Index: 4
Last. Shaokun LiuH-Index: 8
view all 8 authors...
Background: High mobility group box 1 (HMGB1) is an inflammatory mediator involved into the advanced stage of systemic inflammatory response syndrome (SIRS), and is over-expressed in bacterial sepsis and hemorrhagic shock. Recently, it has been found that the HMGB1 was abnormally expressed in induced sputum and plasma of asthmatic patients. However, the precise role of HMGB1 in the acute allergic asthma is unclear. Therefore, we aim to investigate the role HMGB1 in regulating airway inflammation...
#1Libing MaH-Index: 5
#2Jinrong ZengH-Index: 4
Last. Cong-Yi Wang (HUST: Huazhong University of Science and Technology)H-Index: 53
view all 9 authors...
Although atrial natriuretic peptide (ANP) has been well recognized for its role in the regulation of volume-pressure homeostasis in cardiovascular system, its impact on respiratory system, particularly on the pathogenesis of acute allergic asthma, is yet to be elucidated. In the present report, we induced mice with OVA for onset of acute allergic asthma along with the administration of recombinant ANP or {"type":"entrez-protein","attrs":{"text":"A71915","term_id":"7464758","term_text":"pir||A719...
#1Feng-xuan Song (CSU: Central South University)H-Index: 4
#2Xiangchao Zhang (CSU: Central South University)H-Index: 22
Last. Diquan Li (CSU: Central South University)H-Index: 1
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The microstructure and localized corrosion behavior of the 7050-T6 Al alloys treated with different quench transfer time were investigated. Optical microscope observations show that the volume fraction of the recrystallized grains increases slightly with prolonging quench transfer time. Scanning electron microscope observations reveal that the stable η (MgZn2) phase nucleates and precipitates on grain boundaries in the process of transferring to quench. Further observations, using transmission e...
#1Li Xu (CSU: Central South University)H-Index: 3
#2Xudong Xiang (CSU: Central South University)H-Index: 18
Last. Jinxiu Li (CSU: Central South University)H-Index: 11
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ABSTRACTBackground: Chronic persistent asthma is characterized by airway remodeling, in which epithelial–mesenchymal transition (EMT) may play a significant role. Dehydroepiandrosterone (DHEA), a steroid hormone and testosterone analog, is considered as an important immunomodulating hormone. However, its role in EMT remains unclear. We sought to investigate whether transforming growth factor-β1 (TGF-β1) stimulates human bronchial epithelial cells (16HBE-14o) to undergo EMT, and whether this tran...
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