Marianne C. Aznar
University of Oxford
OpticsCancerInternal medicineRadiologyOncologyStage (cooking)Materials scienceMedical physicsRadiation treatment planningLung cancerDeep inspiration breath-holdProton therapyNuclear medicineHodgkin lymphomaPlanning target volumeLocally advancedRadiation therapyBreast cancerMedicineDosimetry
Publications 255
#1Georgios Ntentas (Guy's and St Thomas' NHS Foundation Trust)
#2Katerina Dedeckova (Charles University in Prague)H-Index: 2
Last. David J. Cutter (University of Oxford)H-Index: 14
view all 11 authors...
Abstract null null Purpose null In some Hodgkin lymphoma (HL) patients, proton beam therapy (PBT) may reduce the risk of radiation-related cardiovascular disease (CVD) and second cancers (SC) compared with photon radiotherapy (photon-RT). Our aim was to identify those who benefit most from PBT in terms of predicted 30-year absolute mortality risks (AMR30) from CVD and SC, taking into account individual background, chemotherapy, radiation and smoking-related risks. null null null Methods and Mate...
#1Rosie HalesH-Index: 2
#2Robert Chuter (University of Manchester)H-Index: 20
Last. Cynthia L. Eccles (University of Manchester)H-Index: 17
view all 11 authors...
Purpose null Gadolinium-based contrast agents (GBCAs) may add value to Magnetic Resonance (MR)-only radiotherapy workflows including on hybrid machines such as the MR Linac. The impact of GBCAs on radiotherapy dose distributions however have not been well studied. This work used retrospective GBCA-enhanced datasets to assess the dosimetric effect of GBCAs on head and neck plans. null Methods null Ten patients with oropharyngeal SCC receiving radiotherapy from November 2018-April 2020 were includ...
#1H.C. Chamberlin (University of Manchester)
#2S. Astley (University of Manchester)
Last. Marianne C. Aznar (University of Manchester)H-Index: 32
view all 9 authors...
PURPOSE/OBJECTIVE(S) Women receiving supradiaphragmatic radiotherapy (RT) for Hodgkin Lymphoma (HL) aged ≤ 36y have a greater risk of breast cancer (BC) than the general population. Although RT fields have reduced in recent years, breast tissue (BT) is unavoidably irradiated in many women. Despite the long-term risk, dose to BT is not routinely nor consistently reported: published studies report inconsistent breast dose metrics, or only point dose to the site of a subsequent BC. We hypothesize b...
#1Marianne C. Aznar (University of Manchester)H-Index: 32
#2G. Ntentas (University of Oxford)H-Index: 3
Last. Mario Levis (UNITO: University of Turin)H-Index: 10
view all 7 authors...
In the last decades, the substantial technical progress in radiation oncology offered the opportunity for more accurate planning and delivery of treatment. At the same time, the evolution of systemic treatment and the advent of modern diagnostic tools allowed for more accurate staging and consequently a safe reduction of radiotherapy (RT) target volumes and RT doses in the treatment of lymphomas. As a result, incidental irradiation of organs at risk was reduced, with a consequent reduction of se...
#1Kirsten Hodgson (University Hospitals Birmingham NHS Foundation Trust)H-Index: 2
#2Elizabeth A Larkin (University Hospitals Birmingham NHS Foundation Trust)H-Index: 1
Last. Eliana Vasquez Osorio (University of Manchester)H-Index: 11
view all 4 authors...
Objective:To gauge the current availability of dual-energy computed tomography (DECT) scanners in the UK, establish available technologies, look broadly at current clinical uses in adults and paedi...
Radiotherapy is an integral part of treatment for many patients with breast cancer. However, side effects can occur, Example fibrosis or erythema. If patients at higher risks of radiation induced side effects could be identified before treatment, they could be given more individual information about the risks and benefits of radiotherapy. We hypothesise that breast density is correlated with the risk of side effects and present a novel method for automatic evaluation based on radiotherapy planni...
#1Frances K. Duane (Trinity College, Dublin)
#2Amanda Kerr (University of Oxford)
Last. Carolyn W. Taylor (Trinity College, Dublin)H-Index: 1
view all 7 authors...
Abstract null null Background and Purpose null Breast cancer radiotherapy can increase the risk of subsequent primary oesophageal cancer, with risk increasing according to oesophagus radiation dose. We describe oesophagus exposure from modern breast cancer regimens and discuss the risks of oesophageal cancer for women irradiated recently. null null null Materials and Methods null A systematic review was undertaken of oesophagus doses from breast cancer radiotherapy regimens published during 2010...
#1Andrea LoH-Index: 14
#2Cécile M. RonckersH-Index: 29
Last. Karen J. Marcus (Brigham and Women's Hospital)H-Index: 54
view all 11 authors...
Purpose null Breast hypoplasia and impaired lactation are poorly studied sequelae of chest radiation therapy (RT) in children. The Pediatric Normal Tissue Effects in the Clinic female breast task force aimed to quantitate the radiation dose-volume effects on these endpoints. null null null Methods and Materials null A literature search was conducted of peer-reviewed manuscripts evaluating breast hypoplasia and lactation after chest RT in children, yielding 789 abstracts. Only 2 studies on childr...
#1Orit Kaidar-Person (Sheba Medical Center)H-Index: 2
#2Birgitte Vrou Offersen (Aarhus University Hospital)H-Index: 28
Last. Vratislav Strnad (FAU: University of Erlangen-Nuremberg)H-Index: 30
view all 13 authors...
Abstract null null Delineation of target and ‘organ at risk (OAR)’ volumes is a critical part of modern radiation therapy planning, the next essential step after deciding the indication, patient discussion and image acquisition. Adoption of volume-based treatment planning for non-metastatic breast cancer has increased greatly along with the use of improved planning techniques, essential for modern therapy. However, identifying the volumes on a planning CT is no easy task. The current paper is wr...
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