Sang Youb Han
Inje University
Internal medicineUrologyEndocrinologySurgeryRenal functionChemistryHazard ratioAlbuminuriaInflammationInsulin resistanceHemodialysisKidney diseaseProteinuriaDiabetic nephropathyKidneyKidney transplantationCreatinineNephropathyAngiotensin IITransplantationDiabetes mellitusMedicineUrinary systemBiologyGastroenterology
79Publications
21H-index
1,484Citations
Publications 82
Newest
#2Hyung Ah JoH-Index: 7
Last. Sang Youb HanH-Index: 21
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INTRODUCTION The incidence of fractures is much higher in patients with chronic kidney disease, especially those on hemodialysis (HD). Denosumab is known to treat osteoporosis. However, no exact guideline exists for treatment with denosumab in patients, especially those with diabetes. This study analyzed the effect of denosumab in HD patients with or without diabetes. MATERIALS AND METHODS Dual-energy X-ray absorptiometry was performed in 89 HD patients: 42 were diagnosed with osteoporosis. 33 p...
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#1Hye Sook Min (Wonkwang University)H-Index: 7
#2Ji Eun LeeH-Index: 8
Last. Dae Ryong ChaH-Index: 29
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Cyclosporine A (CyA) is an immunosuppressive agent that induces nephrotoxicity with long-term treatment. The roles of DPP-4 and its inhibitors in cyclosporine nephrotoxicity are not fully understood. Therefore, we investigated the effects of a novel DPP-4 inhibitor, DA-1229, on the progression of renal disease in an experimental cyclosporine nephrotoxicity model. Chronic cyclosporine nephrotoxicity was induced in six-week-old male ICR mice by subcutaneous injections of CyA at a dose of 30 mg/kg ...
1 CitationsSource
#1Sang Youb HanH-Index: 21
#2Kyung Hwan JeongH-Index: 13
Last. Dae Ryong ChaH-Index: 29
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BACKGROUND Imbalance of T helper (Th) 1/2 cells has been shown to contribute to the development of immunoglobulin A nephropathy (IgAN). To address the inconsistent results on the role of Th1/Th2 polarization, we evaluated the levels of Th1/Th2 cytokines in various samples from patients with IgAN. METHODS Thirty-one patients with biopsy-proven IgAN (age, 34.48 ± 12.10 years) and 25 healthy controls (age, 44.84 ± 13.72 years) were enrolled. We evaluated the relationship between the levels of Th1/T...
1 CitationsSource
#1Gyu Sik Choi (KU: Korea University)
#2Hye Sook Min (Wonkwang University)H-Index: 7
Last. Dae Ryong Cha (KU: Korea University)H-Index: 29
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Abstract Background and aims Oxidative stress contributes to development of diabetic nephropathy. We implicated SH3YL1 in oxidative stress-induced inflammation and examined whether SH3YL1 could be used as a new biomarker of diabetic nephropathy. Methods and results In this study, we investigated the relationship between plasma level of SH3YL1 and diabetic nephropathy in patients with type 2 diabetes. In addition, we examined the physiological role of SH3YL1 in db/db mice and cultured podocytes. ...
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#1Heungman Jun (Inje University)H-Index: 4
#2Hyung Ah Jo (Inje University)H-Index: 7
Last. Sang Youb Han (Inje University)H-Index: 21
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Abstract Purpose Hemodynamic management in brain-dead donors (BDDs) is challenging due to hemodynamic instabilities. We compared functional parameters with traditional parameters for hemodynamic monitoring in BDDs. Materials and methods Seventeen BDDs with a positive balance of >500 mL for 8 hours were included. Functional hemodynamic monitoring, including pulse pressure variation (PPV), stroke volume variation (SVV), cardiac output, and systemic vascular resistance index (SVRI) was performed in...
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#1Sang Youb Han (Inje University)H-Index: 21
#2Hye Kyoung Song (KU: Korea University)H-Index: 15
Last. Dae Ryong Cha (KU: Korea University)H-Index: 29
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Background Farnesoid X receptor (FXR) plays a role in homeostasis of bile acid, lipid, and carbohydrate metabolism. However, the systemic effects of FXR in diabetic nephropathy are controversial. We aimed to clarify the systemic effects of FXR on various organs in a type 2 diabetic animal model. Methods We treated db/db mice with the FXR agonist GW4064 for 3 months and evaluated insulin resistance, lipid metabolism, renal functional changes, and structural changes in organs including those of th...
2 CitationsSource
#1Youn Kyung Kee (Sacred Heart Hospital)H-Index: 13
#2Sang Youb Han (Inje University)H-Index: 21
Last. Beom Seok Kim (Yonsei University)H-Index: 23
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PURPOSE Oral adsorbents delay disease progression and improve uremic symptoms in patients with chronic kidney disease (CKD). DW-7202 is a newly developed oral adsorbent with high adsorptive selectivity for uremic toxins. We evaluated patient preference for and adherence to DW-7202 versus AST-120 therapy and compared treatment efficacy and safety in patients with pre-dialysis CKD. MATERIALS AND METHODS A seven-center, randomized, open-label, two-way crossover, active-controlled, phase IV clinical...
1 CitationsSource
#1Eun-Yeung GongH-Index: 1
#2Hyung Ah Jo (Inje University)H-Index: 7
Last. Sang Youb Han (Inje University)H-Index: 21
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High glucose-mediated tubular injury contributes to the development and progression of diabetic nephropathy through renal tubulointerstitial fibrosis. V-set immunoglobulin-domain-containing 4 (VSIG4), a B7 family-related protein, is a complement receptor. Although the role of epithelial-mesenchymal transition (EMT) has been reported in several diseases, little is known about its relationship with VSIG4 under diabetic conditions. This study aimed to investigate the role of VSIG4 in human tubule c...
2 CitationsSource
#1Jun Bae Bang (Ajou University)H-Index: 1
#2Chang-Kwon Oh (Ajou University)H-Index: 13
Last. Ja Young Jeon (Ajou University)H-Index: 17
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Background We investigated the changing patterns of insulin secretion and resistance and risk factors contributing to the development of post-transplant diabetes mellitus (PTDM) in kidney recipients under tacrolimus-based immunosuppression regimen during 1 year after transplantation. Methods This was a multicenter prospective cohort study. Of the 168 subjects enrolled in this study, we analyzed a total 87 kidney transplant recipients without diabetes which was assessed by oral glucose tolerance ...
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#1Jin Joo ChaH-Index: 11
#2Chanchal Mandal (KU: Korea University)H-Index: 8
Last. Dae Ryong ChaH-Index: 29
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Interstitial fibrosis is a common feature of chronic kidney disease, and platelet-derived growth factor receptor-β (PDGFR-β)-positive mesenchymal cells are reportedly the major source of scar-producing myofibroblasts. We had previously demonstrated that albumin and its derivative R-III (a retinol-binding protein-albumin domain III fusion protein) inhibited the transdifferentiation/activation of hepatic stellate cells (HSCs) to myofibroblasts and that R-III administration reduced liver fibrosis. ...
3 CitationsSource