Jung-Ah Hwang
The Breast Cancer Research Foundation
Fusion geneCancerInternal medicineGenotypeCpG siteOncologySingle-nucleotide polymorphismMolecular biologyDNA methylationHaplotypeLung cancerOvarian cancerAdenocarcinomaKRASEpigeneticsCancer researchGeneticsCarcinogenesisBioinformaticsMedicineBiologyGastroenterology
Publications 30
#1Dong Hoon ShinH-Index: 17
#1Dong Hoon ShinH-Index: 3
Last. Ji-Youn HanH-Index: 32
view all 11 authors...
// Dong Hoon Shin 1,5 , Donghoon Lee 2 , Dong Wan Hong 2 , Seung Hyun Hong 2 , Jung-Ah Hwang 2 , Byung Il Lee 3 , Hye Jin You 4 , Geon Kook Lee 1 , In-Hoo Kim 5 , Yeon-Su Lee 2 and Ji-Youn Han 1 1 Lung Cancer Branch, Graduate School of Cancer Science and Policy, National Cancer Center, Ilsandong-gu, Goyang-si, Gyeonggi-do, Republic of Korea 2 Cancer Genomic Branch, Graduate School of Cancer Science and Policy, National Cancer Center, Ilsandong-gu, Goyang-si, Gyeonggi-do, Republic of Korea 3 Biom...
26 CitationsSource
#1Jae Young JoungH-Index: 15
#2Sang-Jin LeeH-Index: 6
Last. Yeon-Su LeeH-Index: 24
view all 12 authors...
Objective: To investigate the association of genetic variants of nerve injury-induced protein 1 (NINJ1) with risk of prostate cancer in Korean men, we performed this association study using single nucleotide polymorphism (SNP). Materials and methods: We enrolled 383 patients with prostate cancer and 373 healthy controls. Twentysix candidate SNPs of the NINJ1 gene were selected for genotype analysis. The distribution of each genotype and haplotype was analyzed, and their association with the inci...
#1Yu Mi WooH-Index: 9
#2Yubin ShinH-Index: 6
Last. Jong Hoon ParkH-Index: 20
view all 10 authors...
Although autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease, and is characterized by the formation of multiple fluid-filled cysts, which results in renal failure, early diagnosis and treatment of ADPKD have yet to be defined. Herein, we observed that the promoter region of the gene encoding mucin-like protocadherin (MUPCDH) was hypermethylated in the renal tissue of patients with ADPKD compared to non-ADPKD controls. Inversely, MUPCDH was significantly repressed in ...
11 CitationsSource
#1Ji-Youn HanH-Index: 32
#2Yeon-Su LeeH-Index: 24
Last. Geon Kook LeeH-Index: 31
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Background: We investigated the clinical implications of NRG1 fusion, a newly identified oncogenic rearrangement, in surgically resected invasive mucinous adenocarcinoma (IMA) of the lung. Patients and Methods: We performed RNA sequencing on 7 lung adenocarcinomas that had no known driver oncogenes and identified a novel fusion, SLC3A2-NRG1 in a case of IMA. The newly detected NRG1 fusion was verified in an IMA cohort of 59 cases using reverse transcription polymerase chain reaction (RT-PCR), di...
#1Jung-Ah HwangH-Index: 13
#2Bo Bin Lee (SKKU: Sungkyunkwan University)H-Index: 10
Last. Duk-Hwan Kim (SKKU: Sungkyunkwan University)H-Index: 26
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This study was aimed at understanding the clinicopathological significance of HOXA9 hypermethylation in non-small cell lung cancer (NSCLC). HOXA9 hypermethylation was characterized in six lung cancer cell lines, and its clinicopathological significance was analyzed using methylation-specific PCR in 271 formalin-fixed paraffin-embedded tissues and 27 fresh-frozen tumor and matched normal tissues from 298 NSCLC patients, and Ki-67 expression was analyzed using immunohistochemistry. The promoter re...
24 CitationsSource
#1Bohyun KimH-Index: 43
#2Yeon-Su LeeH-Index: 24
Last. Joong-Won ParkH-Index: 30
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308 Background: Reliable biomarkers are required to predict patient response to sorafenib. We attempted to investigate genomic variations associated with responsiveness to sorafenib treatment in patients with unresectable hepatocellular carcinoma (HCC) and their functional relevance. Methods: We obtained blood samples from 4 strong and 3 poor responders to sorafenib treatment and subjected these samples to whole-genome analysis. Next, we performed validation tests for candidate single-nucleotide...
#1Young-Joo LeeH-Index: 46
Last. Jin Soo LeeH-Index: 27
view all 6 authors...
Abstract Background It has been reported that the presence of pretreatment EGFR T790M mutation may reduce the efficacy to EGFR tyrosine kinase inhibitors (TKI) in EGFR -mutant lung cancer. However, clinicopathologic features related to the likelihood of T790M mutation before treatment remains unknown. Patients and Methods DNA from 124 pretreatment tissue samples from patients with advanced non–small-cell lung cancer carrying sensitive EGFR mutations was genotyped for EGFR T790M mutation with mas...
15 CitationsSource
#1Boyoung ParkH-Index: 15
#2Aesun ShinH-Index: 51
Last. Eun Sook LeeH-Index: 44
view all 9 authors...
A growing body of evidence suggests that the peroxisome proliferator-activated receptor-gamma (PPARγ) gene may harbor targets for the chemoprevention of breast cancer. However, it is unclear whether polymorphisms in the PPARγ gene are associated with the susceptibility of breast cancer. We performed a candidate gene association study between PPARγ polymorphisms and breast cancer and a meta-analysis on the association of breast cancer with selected PPARγ variants. Six single nucleotide polymorphi...
4 CitationsSource
#1Ji-Youn HanH-Index: 32
#2Sun Hye KimH-Index: 2
Last. Geon Kook LeeH-Index: 31
view all 8 authors...
Abstract Purpose To investigate the clinical utility of targeted next-generation sequencing (NGS) for predicting the responsiveness to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) therapy, we compared the efficacy with conventional sequencing in never-smokers with lung adenocarcinoma (NSLAs). Patients and methods We obtained DNA from 48 NSLAs who received gefitinib or erlotinib for their recurrent disease after surgery. Sanger sequencing and peptide nucleic acid clamp ...
35 CitationsSource
#1Yeon-Su LeeH-Index: 24
#2Yun Sung Cho (Genome Research Foundation)H-Index: 14
Last. Jin Soo LeeH-Index: 21
view all 23 authors...
Background Stomach cancer is the third deadliest among all cancers worldwide. Although incidence of the intestinal-type gastric cancer has decreased, the incidence of diffuse-type is still increasing and its progression is notoriously aggressive. There is insufficient information on genome variations of diffuse-type gastric cancer because its cells are usually mixed with normal cells, and this low cellularity has made it difficult to analyze the genome.
51 CitationsSource