Chun Chieh Fan
University of California, San Diego
Genome-wide association studyInternal medicineOncologySingle-nucleotide polymorphismPsychologyHeritabilityNeuroscienceCognitionGenetic associationDiseaseProstate cancerPopulationLinkage disequilibriumGeneticsApolipoprotein EComputational biologyMedicineCohortBiologyGenetic architecture
135Publications
26H-index
3,117Citations
Publications 116
Newest
#1Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
#2R. J. Loughnan (UCSD: University of California, San Diego)H-Index: 4
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
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It is important to understand the molecular determinants for microstructures of human brain. However, past genome-wide association studies (GWAS) on microstructures of human brain have had limited results due to methodological constraints. Here, we adopt advanced imaging processing methods and multivariate GWAS on two large scale imaging genetic datasets (UK Biobank and Adolescent Brain Cognitive Development study) to identify and validate key genetic association signals. We discovered 503 uniqu...
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#1Weiqiu Cheng (Oslo University Hospital)H-Index: 1
#2Oleksandr Frei (Oslo University Hospital)H-Index: 19
Last. Guy Hindley ('KCL': King's College London)H-Index: 4
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Importance null Schizophrenia is a complex heritable disorder associated with many genetic variants, each with a small effect. While cortical differences between patients with schizophrenia and healthy controls are consistently reported, the underlying molecular mechanisms remain elusive. null Objective null To investigate the extent of shared genetic architecture between schizophrenia and brain cortical surface area (SA) and thickness (TH) and to identify shared genomic loci. null Design, setti...
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#1Daniël Roelfs (Oslo University Hospital)H-Index: 3
#2van der Meer D (UM: Maastricht University)
Last. Tobias Kaufmann (University of Tübingen)H-Index: 35
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Psychiatric disorders are complex, heritable, and highly polygenic. Supported by findings of abnormalities in functional magnetic resonance imaging (fMRI) based measures of brain connectivity, current theoretical and empirical accounts have conceptualized them as disorders of brain connectivity and dysfunctional integration of brain signaling, however, the extent to which these findings reflect common genetic factors remains unclear. Here, we performed a multivariate genome-wide association anal...
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#1Anthony Steven Dick (FIU: Florida International University)H-Index: 21
#2Daniel A Lopez (URMC: University of Rochester Medical Center)H-Index: 2
Last. Andrew T. Marshall (SC: University of Southern California)H-Index: 14
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Abstract null null The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n= 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, e...
3 CitationsSource
#1Bader Chaarani (UVM: University of Vermont)H-Index: 12
#2Sage Hahn (UVM: University of Vermont)H-Index: 2
Last. Matthew D. Albaugh (UVM: University of Vermont)H-Index: 21
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The Adolescent Brain Cognitive Development (ABCD) Study® is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N = 5,547), reward anticipation and receipt with...
2 CitationsSource
#1Clare E. Palmer (University of California, Berkeley)H-Index: 11
#2Diliana Pecheva (UCSD: University of California, San Diego)H-Index: 5
Last. Anders M. DaleH-Index: 166
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During late childhood behavioral changes, such as increased risk-taking and emotional reactivity, have been associated with the maturation of cortico-subcortical circuits. null Understanding microstructural changes in subcortical regions may aid our understanding of how individual differences in these behaviors emerge. null Restriction spectrum imaging (RSI) is a framework for modelling diffusion-weighted imaging that decomposes the diffusion signal from a voxel into hindered and restricted comp...
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#1Clare E. Palmer (University of California, Berkeley)H-Index: 11
#2Diliana Pecheva (UCSD: University of California, San Diego)H-Index: 5
Last. Anders M. DaleH-Index: 166
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Development in late childhood has been associated with microstructural changes in white matter (WM) that are hypothesized to underpin concurrent changes in cognitive and behavioral function. Restriction spectrum imaging (RSI) is a framework for modelling diffusion-weighted imaging that can probe microstructural changes within hindered and restricted compartments providing greater specificity than diffusion tensor imaging for characterizing intracellular diffusion. Using RSI, we modelled voxelwis...
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#1Sarah J. Banks (UCSD: University of California, San Diego)H-Index: 21
#2Murray J. Andrews (UCSD: University of California, San Diego)H-Index: 2
Last. James B. Brewer (UCSD: University of California, San Diego)H-Index: 50
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Abstract null null To determine if sex differences in verbal memory in AD are related to differences in extent or distribution of pathological tau, we studied 275 participants who were amyloid PET positive and carried clinical classifications of normal cognition, mild cognitive impairment (MCI) or dementia, and had tau (AV1451) PET. We compared tau distribution between men and women, and as a function of genetic risk. In MCI we further explored the relationship between quantity and distribution ...
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#1R. J. LoughnanH-Index: 4
#2Alexey A. ShadrinH-Index: 12
Last. Anders M. DaleH-Index: 166
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Genome-Wide Association studies have typically been limited to single phenotypes, given that high dimensional phenotypes incur a large multiple comparisons burden: ~1 million tests across the genome times the number of phenotypes. Recent work demonstrates that a Multivariate Omnibus Statistic Test (MOSTest) is well powered to discover genomic effects distributed across multiple phenotypes. Applied to cortical brain MRI morphology measures, MOSTest has resulted in a drastic improvement in power t...
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#1Meghana S Pagadala (UCSD: University of California, San Diego)H-Index: 3
#2Victoria WuH-Index: 9
Last. Hannah CarterH-Index: 30
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With the continued promise of immunotherapy as an avenue for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer risk screening and treatment strategies. Using genotypes from over 8,000 European individuals in The Cancer Genome Atlas (TCGA) and 137 heritable tumor immune phenotype components (IP components), we identified and investigated 482 TIME associations and 475 unique TIME-associated variants. Many TIME-...
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