Andreas Münch
Linköping University
Quality of lifeInternal medicineSurgeryPathologyImmunologyPlaceboColitisBudesonideCollagenous colitisInflammatory bowel diseaseMicroscopic colitisDiseaseDiarrheaLymphocytic colitisUlcerative colitisAbdominal painIntestinal mucosaIncidence (epidemiology)RefractoryHistopathologyMedicineGastroenterology
62Publications
17H-index
872Citations
Publications 65
Newest
#1Katarina Pihl Lesnovska (Linköping University)H-Index: 3
#2Andreas Münch (Linköping University)H-Index: 17
Last. Henrik Hjortswang (Linköping University)H-Index: 25
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BACKGROUND & AIMS Patient-reported outcome measures (PROMs) aim to measure patients' perception of how their disorder influences everyday functioning. The objective of this study was to develop a PROM to assess disease activity in microscopic colitis (MC) fulfilling the requirements of the Food and Drug Administration (FDA). METHODS The European Microscopic Colitis Activity Index (E-MCAI) was developed in four steps: 1) A list of symptoms associated with active MC was created by a group of exper...
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#1Andreas Münch (Linköping University)H-Index: 17
#2Emese Mihály (Semmelweis University)H-Index: 6
Last. Blanca Belloc (University of Zaragoza)H-Index: 1
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BACKGROUND AND AIMS Incomplete microscopic colitis (MCi) is a subtype of microscopic colitis (MC). Budesonide is recommended as a first-line treatment for MC. However, randomised trials on efficacy of treatment in MCi are missing. We therefore performed a randomised, placebo-controlled trial to evaluate budesonide as induction therapy for MCi. METHODS Patients with active MCi were randomly assigned to either budesonide 9 mg once daily or placebo for 8 weeks in a double-blind, double-dummy design...
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#1Ingunn Bakke (NTNU: Norwegian University of Science and Technology)H-Index: 15
#2Gunnar Andreas Walaas (NTNU: Norwegian University of Science and Technology)H-Index: 1
Last. Ann Elisabet Østvik (NTNU: Norwegian University of Science and Technology)H-Index: 10
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Background null Collagenous colitis (CC) is an inflammatory bowel disease where chronic diarrhoea is the main symptom. Diagnostic markers distinguishing between CC and other causes of chronic diarrhoea remain elusive. This study explores neutrophil gelatinase-associated lipocalin (NGAL) and its mRNA lipocalin2 (LCN2) as histological and faecal disease markers in CC. null Methods null NGAL/LCN2 were studied in colonic biopsies from CC patients before and during budesonide treatment using RNA sequ...
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#1Niki Daferera (Linköping University)H-Index: 2
Last. Andreas Münch (Linköping University)H-Index: 17
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BACKGROUND AND AIM Increased frequencies of T regulatory (Treg) cells, key players in immune regulation, have been reported in inflammatory bowel diseases, including collagenous colitis (CC). However, traditional Treg identification techniques might have misinterpreted the frequencies of Treg cells in CC. Thus, we investigated the presence of genuine Treg cells in CC. METHODS Treg cells were analyzed in mucosal and peripheral blood samples of CC patients before and during treatment with the cort...
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#1Yamile ZabanaH-Index: 19
#2Gian Eugenio Tontini (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 20
Last. Stephan Mielhke (Eppendorf (Germany))H-Index: 1
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Background null While the exact aetiology of microscopic colitis (MC) remains unknown, a dysregulated immune response to luminal factors or medications is the most accepted pathogenesis hypothesis. null Objective null Systematic review of the pathogenesis of MC. null Methods null We applied the Joanna Briggs Institute methodologies and the PRISMA statement for the reporting of systematic reviews (PROSPERO Trial Identifier: CRD42020145008). Populations, Exposure of interest and Outcome (PEO) ques...
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#1Petra WeimersH-Index: 6
Last. Johan BurischH-Index: 39
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Objective null Microscopic colitis (MC), encompassing collagenous colitis (CC) and lymphocytic colitis (LC), is an increasingly prevalent gastrointestinal disease with an unknown aetiology. Previous research has reported significant differences in the incidence of MC within Denmark, with the lowest incidence found in the most populated region (Capital Region of Denmark). Our aim was to elucidate the causes of these regional differences. null Design null All incident MC patients (n=14,302) with a...
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BACKGROUND Microscopic colitis (MC) is a common cause of chronic watery diarrhea. Biopsies with characteristic histological features are crucial for establishing the diagnosis. The two main subtypes are collagenous colitis (CC) and lymphocytic colitis (LC) but incomplete forms exist. The disease course remains unpredictable varying from spontaneous remission to a relapsing course. AIM To identify possible histological predictors of course of disease. METHODS Sixty patients from the European pros...
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#1Celia Escudero-Hernández (Linköping University)H-Index: 5
#2Atle van Beelen Granlund (NTNU: Norwegian University of Science and Technology)H-Index: 14
Last. Andreas Münch (Linköping University)H-Index: 17
view all 7 authors...
abstract Background and Aims The pathophysiology of the inflammatory bowel disease collagenous colitis (CC) is poorly described. Our aim was to use RNA sequencing of mucosal samples from patients with active CC, CC in remission, refractory CC, ulcerative colitis (UC), and controls to gain insight into CC pathophysiology, identify genetic signatures linked to CC, and uncover potentially druggable disease pathways. Methods We performed whole transcriptome sequencing of CC samples from patients bef...
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#1Petra WeimersH-Index: 6
Last. Johan BurischH-Index: 39
view all 8 authors...
BACKGROUND AND AIMS The disease course of microscopic colitis [MC], encompassing collagenous colitis [CC] and lymphocytic colitis [LC], is not well known. In a Danish nationwide cohort, we evaluated the disease activity patterns as well as the risk of colorectal cancer [CRC] and mortality based on disease severity. METHODS All incident MC patients [n = 14 302] with a recorded diagnosis of CC [n = 8437] or LC [n = 5865] in the Danish Pathology Register, entered between 2001 and 2016, were matched...
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