Joshua B. Ewen
Kennedy Krieger Institute
PsychiatryPsychologyNeuroscienceCognitionMotor skillAlpha (ethology)Cognitive psychologyAutismGestureWorking memoryEpilepsyPolysomnographyAutism spectrum disorderSturge–Weber syndromeTask (project management)Attention deficit hyperactivity disorderSleep StagesElectroencephalographyClinical trialAudiologyMedicineCohort
Publications 59
#1Yu Luo (Beihang University)
#2C. Chen (ICSCI: Kennedy Krieger Institute)
Last. Joshua B. Ewen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 15
view all 6 authors...
Abstract null null Mirror overflow is involuntary movement that accompanies unilateral voluntary movement on the opposite side of the body, and is commonly seen in Attention-Deficit/Hyperactivity Disorder (ADHD). Children with ADHD show asymmetry in mirror overflow between dominant and non-dominant hand, yet there are competing mechanistic accounts of why this occurs. Using EEG during a sequential, unimanual finger-tapping task, we found that children with ADHD exhibited significantly more mirro...
#1Tiziana Vercillo (UR: University of Rochester)H-Index: 10
#2Edward G. Freedman (UR: University of Rochester)H-Index: 19
Last. John J. Foxe (UR: University of Rochester)H-Index: 96
view all 5 authors...
Multisensory objects that are frequently encountered in the natural environment lead to strong associations across a distributed sensory cortical network, with the end result experience of a unitary percept. Remarkably little is known, however, about the cortical processes sub-serving multisensory object formation and recognition. To advance our understanding in this important domain, the present study investigated the brain processes involved in learning and identification of novel visual-audit...
#1Joshua B. Ewen (ICSCI: Kennedy Krieger Institute)H-Index: 15
#2Nicolaas A.J. PutsH-Index: 30
Last. Donald L. GilbertH-Index: 52
view all 5 authors...
Children with attention-deficit/hyperactivity disorder (ADHD) have previously shown a decreased magnitude of event-related desynchronization (ERD) during a finger-tapping task, with a large between-group effect. Because the neurobiology underlying several TMS measures have been studied in multiple contexts, we compared ERD and three TMS measures (Resting Motor Threshold [RMT], Short-Interval Cortical Inhibition [SICI] and Task-Related Up-Modulation [TRUM]) within 14 participants with ADHD (ages ...
#1Ryan E. Gill (ICSCI: Kennedy Krieger Institute)
#2Bohao Tang (Johns Hopkins University)H-Index: 2
Last. Doris D. M. Lin (Johns Hopkins University)H-Index: 30
view all 14 authors...
Abstract null null Objective null Port-wine birthmark (PWB) is a common occurrence in the newborn, and general pediatricians, dermatologists, and ophthalmologists are often called on to make an assessment of risk for Sturge-Weber syndrome (SWS) due to workforce shortages in pediatric neurologists and MRI’s low sensitivity for SWS brain involvement in infants. We therefore aimed to develop a quantitative EEG (qEEG) approach to safely screen young infants with PWB for SWS risk and optimal timing o...
#1April R. Levin (Boston Children's Hospital)H-Index: 15
#2Joshua B. EwenH-Index: 15
#1Nicholas F. Wymbs (ICSCI: Kennedy Krieger Institute)H-Index: 1
#2Mary Beth Nebel (ICSCI: Kennedy Krieger Institute)H-Index: 24
Last. Stewart H. Mostofsky (ICSCI: Kennedy Krieger Institute)H-Index: 78
view all 4 authors...
Children with autism spectrum disorder (ASD) have difficulties perceiving and producing skilled gestures, or praxis. The inferior parietal lobule (IPL) is crucial to praxis acquisition and expression, yet how IPL connectivity contributes to autism-associated impairments in praxis as well as social-communicative skill remains unclear. Using resting-state functional magnetic resonance imaging, we applied independent component analysis to test how IPL connectivity relates to praxis and social-commu...
#1Alison J. SeboldH-Index: 1
#2Alyssa M. DayH-Index: 3
Last. Anne M. Comi (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 34
view all 17 authors...
Background Sturge-Weber syndrome is a rare neurovascular disorder associated with capillary malformation, seizures, cognitive impairments, and stroke-like episodes (SLEs), arising from a somatic activating mutation in GNAQ. Studies suggest this mutation may cause hyperactivation of the mammalian target of rapamycin pathway. Sirolimus is an mammalian target of rapamycin inhibitor studied in other vascular anomalies and a potentially promising therapy in Sturge-Weber syndrome. Methods Ten patients...
#1Joshua B. Ewen (Johns Hopkins University)H-Index: 15
#2William Z. Potter (NIH: National Institutes of Health)H-Index: 75
Last. John A. Sweeney (UC: University of Cincinnati)H-Index: 117
view all 3 authors...
Abstract Our current diagnostic methods for treatment planning in Psychiatry and Neurodevelopmental Disabilities leave room for improvement, and null results in clinical trials in these fields may be a result of insufficient tools for patient stratification. Great hope has been placed in novel technologies to improve clinical and trial outcomes, but we have yet to see a substantial change in clinical practice. As we examine attempts at biomarker validation within these fields, we find that it ma...
#1Danielle McAuliffe (ICSCI: Kennedy Krieger Institute)H-Index: 5
#2Yi Zhao (Johns Hopkins University)H-Index: 12
Last. Joshua B. Ewen (Johns Hopkins University)H-Index: 15
view all 8 authors...
Autism spectrum disorder (ASD) consists of altered performance of a range of skills, including social/communicative and motor skills. It is unclear whether this altered performance results from atypical acquisition or learning of the skills or from atypical "online" performance of the skills. Atypicalities of skilled actions that require both motor and cognitive resources, such as abnormal gesturing, are highly prevalent in ASD and are easier to study in a laboratory context than are social/comm...
#1Danielle McAuliffe (ICSCI: Kennedy Krieger Institute)H-Index: 5
#2Kathryn Hirabayashi (ICSCI: Kennedy Krieger Institute)H-Index: 2
Last. Joshua B. Ewen (Johns Hopkins University)H-Index: 15
view all 10 authors...
Children with ADHD show developmentally abnormal levels of mirror overflow-unintentional movements occurring symmetrically opposite of intentional movements. Because mirror overflow correlates with ADHD behavioral symptoms, the study of disinhibition in motor control may shed light on physiologic mechanisms underlying impaired behavioral/cognitive control. This is a case-controlled study of EEG recording from 25 children with ADHD and 25 typically developing (TD) controls performing unilateral s...
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