Linnéa Taylor
Lund University
AnatomyDownregulation and upregulationPathologyNeuroscienceChemistryGlial cell line-derived neurotrophic factorOxidative stressRetinaGliosisRetinal detachmentGlial fibrillary acidic proteinRetinalRetinal degenerationGanglionTransplantationCell survivalIn vitro modelCell activationProgrammed cell deathBiologyCell biology
30Publications
9H-index
182Citations
Publications 29
Newest
#1Linnéa Taylor (Lund University)H-Index: 9
#2Karin Arnér (Lund University)H-Index: 17
Last. Fredrik Ghosh (Lund University)H-Index: 19
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#1Linnéa Taylor (Lund University)H-Index: 9
#2Hodan Abdshill (Lund University)H-Index: 3
Last. Fredrik Ghosh (Lund University)H-Index: 19
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#1Fredrik Ghosh (Lund University)H-Index: 19
#2Bo Åkerström (Lund University)H-Index: 56
Last. Linnéa TaylorH-Index: 9
view all 6 authors...
The purpose of this study was to explore acute tissue reactions, ultrastructural photoreceptor morphology with emphasis on inner segments, and the effect of antioxidant treatment in an in vitro model of rhegmatogenous retinal detachment (RRD). A previously described method of RRD simulation was used with adult retinal porcine explants kept free-floating in culture medium with or without treatment with the radical scavenger α1-microglobulin (A1M). Explants were examined at 5 time points from 1 to...
2 CitationsSource
#1Fredrik Ghosh (Lund University)H-Index: 19
#2Hodan Abdshill (Lund University)H-Index: 3
Last. Linnéa Taylor (Lund University)H-Index: 9
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Abstract The purpose of this study was to explore retina-intrinsic neuroinflammatory reactions, effects on neuronal survival, relationship with classic gliosis, and possible role of the toll-like receptor 4 (TLR4). To isolate the adult retina from the systemic immune system, a previously described large animal explant culture model was used in which full-thickness porcine retinal sheets can be kept in vitro for extended time periods. Explants were kept for 5 days in vitro (DIV) and were treated ...
6 CitationsSource
#1Linnéa Taylor (Lund University)H-Index: 9
#2Karin Arnér (Lund University)H-Index: 17
Last. Fredrik Ghosh (Lund University)H-Index: 19
view all 7 authors...
The purpose of this study was to investigate the adhesion properties and tissue reactions in an in vitro model of nanofabricated membranes emulating the vitreous cortex. Electrospinning was performed for either 5, 10 or 15 min to create various thicknesses of poly(e-caprolactone) (PCL) fibre mats on a poly(glycerol-co-sebacic acid) (PGS) surface. These were fused with adult porcine retinal explants, with the fibre side facing the inner retina, and cultured for 5 days. Adherence was assessed by m...
5 CitationsSource
#1Bo Åkerström (Lund University)H-Index: 56
#2Martin Cederlund (Lund University)H-Index: 5
Last. Linnéa Taylor (Lund University)H-Index: 9
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PURPOSE:The purpose of this study was to explore the relationship between oxidative stress, antioxidant defense, mitochondrial structure, and biomechanical tissue support in the isolated porcine retina.METHODS:Full-thickness retinal sheets were isolated from adult porcine eyes. Retinas were cultured for 2 or 48 h using (1) a previously established low-support explant protocol with photoreceptors positioned against the culture membrane (porous polycarbonate) or (2) a high-support procedure develo...
7 CitationsSource
#1Linnéa Taylor (Lund University)H-Index: 9
#2Karin Arnér (Lund University)H-Index: 17
Last. Fredrik Ghosh (Lund University)H-Index: 19
view all 3 authors...
Signaling through the polymodal cation channel Transient Receptor Potential Vanilloid 4 (TRPV4) has been implicated in retinal neuronal degeneration. To further outline the involvement of this channel in this process, we here explore modulation of Transient Receptor Potential Vanilloid 4 (TRPV4) activity on neuronal health and glial activation in an in vitro model of retinal degeneration. For this purpose, adult porcine retinal explants were cultured using a previously established standard proto...
14 CitationsSource
#1Jens Nääv Ottosson (Lund University)
#2Linnéa Taylor (Lund University)H-Index: 9
Last. Fredrik Ghosh (Lund University)H-Index: 19
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#1Oscar Manouchehrian (Lund University)H-Index: 4
#2Karin Arnér (Lund University)H-Index: 17
Last. Linnéa Taylor (Lund University)H-Index: 9
view all 7 authors...