Shusen Zheng
Zhejiang University
CancerInternal medicineRadiologySurgeryPathologyOncologyChemistryApoptosisImmunologyCirrhosisCarcinomaHepatocellular carcinomaMetastasisLiver transplantationTransplantationCancer researchCell growthMedicineBiologyGastroenterology
Publications 913
#1Xu Mengxiang (ZJU: Zhejiang University)
#2Xinyi Zhao (ZJU: Zhejiang University)H-Index: 3
Last. Ming D. Li (ZJU: Zhejiang University)H-Index: 49
view all 10 authors...
Abstract null null Although long non-coding RNAs (lncRNAs) play important roles in tumorigenesis, the underlying mechanisms are unclear. Transcriptomic analysis of 33 hepatocellular carcinoma (HCC) samples revealed that the most enriched pathway for differentially expressed genes was related to the cell cycle process, where DDX11-AS1 is the most significant lncRNA. Upregulation of DDX11-AS1 expression through demethylation was significantly associated with a poor prognosis. Further mechanistic s...
#1Zhikun Liu (ZJU: Zhejiang University)H-Index: 12
#2Jiangwei Ye (ZJU: Zhejiang University)
Last. Xiao Xu (ZJU: Zhejiang University)H-Index: 20
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#1Ming-Chun Lai (ZJU: Zhejiang University)H-Index: 4
#2Lei Geng (ZJU: Zhejiang University)H-Index: 13
Last. Junfang Deng (ZJU: Zhejiang University)H-Index: 6
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BACKGROUND Primary intrahepatic bile duct dilatation can be very harmful to patients although it belongs to benign biliary disease. It can occur in any part of the liver, intraoperative laparoscopic ultrasound (LUS) guidance combine with real-time indocyanine green (ICG) fluorescence navigation are the means of choice for accurate surgical resection. CASE PRESENTATION Herein we reported a 43-year-old female patient presented with repeated right upper abdominal pain and distension for 3 years and...
#1Yuanxing Liu (ZJU: Zhejiang University)H-Index: 6
#2Xi Liu (ZJU: Zhejiang University)
Last. Jun Yu (ZJU: Zhejiang University)H-Index: 1
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Abstract null null Background null Nonalcoholic fatty liver disease (NAFLD) is a public health challenge and significant cause of morbidity and mortality worldwide. Early identification is crucial for disease intervention. We recently proposed a nomogram-based NAFLD prediction model from a large population cohort. We aimed to explore machine learning tools in predicting NAFLD. null null null Methods null A retrospective cross-sectional study was performed on 15 315 Chinese subjects (10 373 train...
#1Wenhui Zhang (ZJU: Zhejiang University)
#2Zhikun Liu (ZJU: Zhejiang University)H-Index: 12
Last. Xiao Xu (ZJU: Zhejiang University)H-Index: 20
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PURPOSE The prediction of microvascular invasion (MVI) has increasingly been recognized to reflect prognosis involving local invasion and distant metastasis of hepatocellular carcinoma (HCC). The aim of this study was to assess a predictive model using preoperatively accessible clinical parameters and radiographic features developed and validated to predict MVI. This predictive model can distinguish clinical outcomes after liver transplantation (LT) for HCC patients. METHODS In total, 455 HCC pa...
#1Jiongjie Yu (ZJU: Zhejiang University)
Last. Zhengxin Wang (Fudan University)H-Index: 1
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Abstract null null Background null The incidence of portal vein tumor thrombus (PVTT) has been reported to be as high as approximately 10%–40% in patients with hepatocellular carcinoma (HCC). The long-term prognosis of deceased donor liver transplantation (DDLT) in HCC patients with PVTT remains unknown. null null null Methods null Data of 961 HCC patients who underwent DDLT between 2015 and 2018 in six centers were analyzed. Based on the Milan criteria (MC) and Cheng's classification of PVTT, t...
#1Jiong Yu (ZJU: Zhejiang University)H-Index: 11
#2Xiaowei Shi (ZJU: Zhejiang University)H-Index: 6
Last. Lanjuan Li (ZJU: Zhejiang University)H-Index: 90
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The relationship between aseptic systemic inflammation and postoperative bacterial infection is unclear. We investigated the correlation of systemic inflammation biomarkers with 30-day clinically significant bacterial infections (CSI) after liver transplantation (LT). This retrospective study enrolled 940 patients who received LT and were followed for 30 days. The primary end point was 30-day CSI events. The cohort was divided into exploratory (n = 508) and validation (n = 432) sets according to...
#2Min XiaoH-Index: 1
Last. Shusen Zheng (ZJU: Zhejiang University)H-Index: 64
view all 8 authors...
#1Lele Zhang (ZJU: Zhejiang University)H-Index: 4
#2Jiacheng Huang (ZJU: Zhejiang University)H-Index: 3
Last. Lin Zhou (ZJU: Zhejiang University)H-Index: 54
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BACKGROUND Cancer vaccines are a promising strategy for cancer immunotherapy. Cancer vaccines elicits a specific cytotoxic immune response to tumor antigens. However, the efficacy of traditional peptide-based cancer vaccines is limited due to the inefficient delivery of antigens and adjuvants to dendritic cells (DCs). Therefore, it is necessary to develop a novel rationally designed cancer vaccine to maximize its desired effects. METHODS A Self-assembling Vehicle-free Multi-component Antitumor n...
#1Quirino Lai (UCL: Université catholique de Louvain)H-Index: 20
#2Gonzalo Sapisochin (TGH: Toronto General Hospital)H-Index: 23
Last. Tiffany C.L. Wong (HKU: University of Hong Kong)H-Index: 10
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Importance Living-donor liver transplant (LDLT) offers advantages over deceased-donor liver transplant (DDLT) of improved intention-to-treat outcomes and management of the shortage of deceased-donor allografts. However, conflicting data still exist on the outcomes of LDLT in patients with hepatocellular carcinoma (HCC). Objective To investigate the potential survival benefit of an LDLT in patients with HCC from the time of waiting list inscription. Design, Setting, and Participants This multicen...
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