Jin-Di Xu
Nanjing University of Chinese Medicine
AnalyteAnalytical chemistryMetabolomeMass spectrometryOrganic chemistryHigh-performance liquid chromatographyChemistryDecoctionGlycosideIn vivoMetabolomicsGinsenosidePaeoniflorinGinsengHerbFumigationMoutan cortexRehmanniae RadixIridoid GlycosidesToxicityMedicinal herbsChemical markerQuadrupole time of flightFood scienceChromatographySulfurGut floraTraditional medicineMetabolismMedicineHydrolysisPharmacology
41Publications
11H-index
442Citations
Publications 39
Newest
Chang-Kang-Fang formula (CKF), a multi-herbs traditional Chinese medicine (TCM) prescription for treating irritable bowel syndrome (IBS), has been clinically applied in the traditional form of mixed-herb decoction (MHD), or in the modern form of combined single-herb decoction (cSHD, so called dispensing granule decoction) in the near decades, but the chemical consistency between the MHD and cSHD is still unknown. Herein, a new strategy by integrating multiple-chromatographic approaches to charac...
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#1Shan-Shan ZhouH-Index: 10
#2Jing ZhouH-Index: 3
Last. Song-Lin LiH-Index: 26
view all 11 authors...
The therapeutic effects of water extract of ginseng (WEG) on exercise-induced fatigue (EF) have been reported in several previous studies, but the molecular mechanisms involved remain unexplored. In this study, the anti-EF effects of WEG were studied, and the potential mechanisms were discussed. We characterized the chemical components of WEG by ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry (UHPLC-QqQ-MS/MS) and high performance liquid chromatography cou...
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#1Ye-Ting Zou (Nanjing University of Chinese Medicine)H-Index: 3
#2Jing Zhou (Nanjing University of Chinese Medicine)H-Index: 8
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 9 authors...
Abstract Ethnopharmacological relevance Poria cocos (Schw.) Wolf (Poria) is a well-known traditional medicinal fungus. It has been considered to possess spleen-invigorating (Jianpi) effects in traditional Chinese medicine, and is used clinically to treat spleen deficiency (Pixu) with symptoms of intestinal disorders such as diarrhea, indigestion, mucositis and weight loss. The aim of this study To investigate the protective effects of Poria and its three component fractions (Water-soluble polysa...
2 CitationsSource
#1Qiao Zhang (Nanjing University of Chinese Medicine)H-Index: 6
#2Zhen-Lan Li (Nanjing University of Chinese Medicine)H-Index: 1
Last. Li Zhang (Nanjing University of Chinese Medicine)H-Index: 22
view all 10 authors...
ETHNOPHARMACOLOGICAL RELEVANCE Shizaotang (SZT), consisted of Euphorbia kansui S.L.Liou ex S.B.Ho (EK), Euphorbia pekinensis Rupr. (EP), Daphne genkwa Sieb. et Zucc. (DG,fried) and Ziziphus jujuba Mill. (ZJ), is usually used for treating malignant pleural effusions (MPE), but the toxicity of EK and EP limits its clinical safe application. It was reported that vinegar processing can reduce the toxicity of EK and EP. Whether EK and EP processing with vinegar can cause the reduced toxicity and reta...
1 CitationsSource
#1Si Chen (Nanjing University of Chinese Medicine)H-Index: 1
#2Yan Lu (Nanjing University of Chinese Medicine)H-Index: 1
Last. Peijuan Wang (Nanjing University of Chinese Medicine)H-Index: 1
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Abstract Ethnopharmacological relevance Bu Shen Huo Xue Tang (BSHXT) is a traditional Chinese medicine formula that is clinically used in the treatment of premature ovarian insufficiency (POI). However, its therapeutic mechanism remains unclear. Aim of the study This study aimed to investigate the underlying molecular mechanism of pharmacological activity of BSHXT, via the Nrf2/Keap1 signaling pathway, in the treatment of autoimmune POI. Materials and Methods The chemical composition of BSHXT wa...
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#1Xin-Ci Cao (Nanjing University of Chinese Medicine)H-Index: 1
#2Meng-Fei Guo (Nanjing University of Chinese Medicine)
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
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Abstract Cicadae Periostracum (CP), the cast-off shell of Cryptotympana atrata, is specified in Chinese Pharmacopoeia for relieving fever and eliminating ulcer. N-acetyldopamine oligomers are the major characteristic bioactive components with antioxidant and anti-inflammatory activities that may be responsible for the efficacy of CP. However, the exposed components and metabolites of N-acetyldopamine oligomers of CP (NOCP) in vivo are still unknown. In present study, the metabolic profile of tot...
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#1Jin-Hao Zhu (Nanjing University of Chinese Medicine)
#1Jin-Hao Zhu (Nanjing University of Chinese Medicine)
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 9 authors...
Ginseng is usually consumed as a dietary supplement for health care in the normal state or prescribed as a herbal medicine in pathologic conditions. Although metabolic studies of ginseng are commonly performed on healthy organisms, the metabolic characteristics in pathologic organisms remain unexplored. This study aimed to uncover the difference in intestinal metabolism of ginseng between normal and cyclophosphamide-induced immunosuppressed rats and further discuss the potential mechanisms invol...
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#1Cheng-Ying Wu (Nanjing University of Chinese Medicine)H-Index: 5
#2Jing Zhou (Peking Union Medical College)H-Index: 3
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 8 authors...
In the present study, the hypoglycemic effects of glucomannan (AGM) and its enzyme-degraded products from Amorphophallus albus were investigated. Four degraded products were prepared through ultrafiltration of β-glucanase-degraded products of AGM. The hypoglycemic activities were evaluated in HFD-STZ-induced type 2 diabetes mellitus (T2DM) mice, and the diversity of gut bacteria was analyzed by 16S rRNA gene sequencing; the fecal short chain fatty acids (SCFAs) and endogenous metabolites were de...
1 CitationsSource
#1Fei Xu (Nanjing University of Chinese Medicine)
#2Ming Kong (Nanjing University of Chinese Medicine)H-Index: 11
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 6 authors...
Abstract Sulfur fumigation and heating desulfurization are used together in the post-harvest processing of many medicinal herbs. However, little is known about the effects of sulfur fumigation on saccharide components, nor about the effects of heating desulfurization on all herbal constituents. In this study, metabolomics and glycomics were integrated to investigate the effects of these two processes on the chemistry of Codonopsis Radix (CR) as a pilot study. The results showed that both sulfur ...
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#1Hong Shen (Nanjing University of Chinese Medicine)H-Index: 14
#2Li Zhang (Nanjing University of Chinese Medicine)H-Index: 22
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 11 authors...
Abstract Ethnopharmacological relevance Sulfur-fumigation has been developed to prevent insects and molds during post-harvest handling of Panax ginseng C.A. Mey (ginseng) in the near decades. Our previous study indicated sulfur-fumigation could transform ginsenosides, the active components of ginseng, into sulfur-containing derivatives (SFCDs), the artifacts with unknown toxicity. However, whether the biotransformation could be occurred and absorption characteristics between ginsenosides and SFC...
4 CitationsSource