Michael V. Lombardo
University of Cambridge
Developmental psychologyDefault mode networkPsychologyNeuroscienceCognitionCognitive psychologyMentalizationAutismAsperger syndromeNeurotypicalAutism spectrum disorderSex characteristicsFunctional magnetic resonance imagingTheory of mindEmpathyWhite matterPopulationAudiologyNeuroimagingResting state fMRIClinical psychologyMedicineBiology
145Publications
56H-index
8,328Citations
Publications 132
Newest
#1Natasha Bertelsen (IIT: Istituto Italiano di Tecnologia)H-Index: 1
#2Isotta Landi (IIT: Istituto Italiano di Tecnologia)
Last. Michael V. Lombardo (University of Cambridge)H-Index: 56
view all 35 authors...
Abstract Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and is underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here we developed a phenotypic stratification model that makes highly accurate (96-98%) out-of-sample SC=RRB, SC...
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#1Tanya L. Procyshyn (University of Cambridge)H-Index: 1
#1Tanya L. Procyshyn (University of Cambridge)H-Index: 6
Last. Richard A.I. Bethlehem (University of Cambridge)H-Index: 15
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BACKGROUND: Oxytocin administration, which may be of therapeutic value for individuals with social difficulties, is likely to affect endogenous levels of other socially relevant hormones. However, to date, the effects of oxytocin administration on endogenous hormones have only been examined in neurotypical individuals. The need to consider multi-hormone interactions is particularly warranted in oxytocin trials for autism due to evidence of irregularities in both oxytocin and sex steroid systems....
1 CitationsSource
#1Saashi A Bedford (McGill University)H-Index: 2
#2Min Tae M. Park (UWO: University of Western Ontario)H-Index: 18
Last. M. Mallar ChakravartyH-Index: 67
view all 27 authors...
Significant heterogeneity across aetiologies, neurobiology and clinical phenotypes have been observed in individuals with autism spectrum disorder (ASD). Neuroimaging-based neuroanatomical studies of ASD have often reported inconsistent findings which may, in part, be attributable to an insufficient understanding of the relationship between factors influencing clinical heterogeneity and their relationship to brain anatomy. To this end, we performed a large-scale examination of cortical morphomet...
48 CitationsSource
#1Saashi A Bedford (McGill University)H-Index: 2
#2Min Tae M. Park (UWO: University of Western Ontario)H-Index: 18
Last. M. Mallar ChakravartyH-Index: 67
view all 27 authors...
1 CitationsSource
#1Carolin Moessnang (Heidelberg University)H-Index: 11
#2Sarah Baumeister (Heidelberg University)H-Index: 19
Last. Andreas Meyer-Lindenberg (Heidelberg University)H-Index: 114
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Background Autism spectrum disorder (ASD) is a neurodevelopmental condition with key deficits in social functioning. It is widely assumed that the biological underpinnings of social impairment are neurofunctional alterations in the “social brain,” a neural circuitry involved in inferring the mental state of a social partner. However, previous evidence comes from small-scale studies and findings have been mixed. We therefore carried out the to-date largest study on neural correlates of mentalizin...
9 CitationsSource
#1Stavros Trakoshis (UCY: University of Cyprus)H-Index: 2
#2Pablo Martínez-Cañada (IIT: Istituto Italiano di Tecnologia)H-Index: 6
Last. Michael V. Lombardo (IIT: Istituto Italiano di Tecnologia)H-Index: 56
view all 16 authors...
Imbalance between neurophysiological excitation versus inhibition (E:I) has been theorized as a core pathophysiological mechanism of autism. However, a majority of the evidence behind the E:I theory comes from animal models of rare genetic mutations that account for only a small fraction of the autistic population. Scale-free metrics of neural time-series data could represent biomarkers for E:I imbalance and could enable a greater understanding of how E:I imbalance affects different types of aut...
2 CitationsSource
#1Michael V. Lombardo (University of Cambridge)H-Index: 56
#2Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
Last. Karen Pierce (UCSD: University of California, San Diego)H-Index: 51
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Many parents of children with autism spectrum disorder (ASD) spot the first signs when their child is still a toddler, by noticing that their child is less interested than other toddlers in people and in social play. These early differences in behavior can have long-term implications for brain development. The brains of toddlers with little interest in social stimuli will receive less social input than those of other toddlers. This will make it even harder for the brain to develop the circuits r...
11 CitationsSource
#1Xiaonan Guo (University of Electronic Science and Technology of China)H-Index: 14
#2Tiago Simas (University of Cambridge)H-Index: 10
Last. John Suckling (University of Cambridge)H-Index: 102
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Autism is a neurodevelopmental condition characterized by atypical brain functional organization. Here we investigated the intrinsic indirect (semi‐metric) connectivity of the functional connectome associated with autism. Resting‐state functional magnetic resonance imaging scans were acquired from 65 neurotypical adults (33 males/32 females) and 61 autistic adults (30 males/31 females). From functional connectivity networks, semi‐metric percentages (SMPs) were calculated to assess the proportion...
4 CitationsSource
#1Juan Manuel Górriz (UGR: University of Granada)H-Index: 45
#2Javier Ramírez (UGR: University of Granada)H-Index: 50
Last. John Suckling (University of Cambridge)H-Index: 102
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This work was partly supported by the MINECO under the TEC2015-64718-R project, the Salvador de Madariaga Mobility Grants 2017 and the Consejer´ia de Econom´ia, Innovaci´on, Ciencia y Empleo (Junta de Andaluc´ia, Spain) under the Excellence Project P11-TIC-7103. The study was conducted in association with the National Institute for Health Research Collaborations for Leadership in Applied Health Research and Care (NIHR CLAHRC) East of England (EoE). The project was supported by the UK Medical Res...
15 CitationsSource
#1Michael V. Lombardo (University of Cambridge)H-Index: 56
#2Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
Last. Karen Pierce (UCSD: University of California, San Diego)H-Index: 51
view all 8 authors...
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