Yuqiang Wang
Jinan University
CytotoxicityBiological activityChemistryApoptosisConjugateIn vitroIn vivoNeuroprotectionOxidative stressTetramethylpyrazineNitroneMemantineNeurotoxicityAndrographolideBiochemistryStereochemistryMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyCell biologyPharmacology
Publications 121
#1Mei Jing (JNU: Jinan University)H-Index: 4
#2Yun Cen (MOE: Chinese Ministry of Education)
Last. Gaoxiao Zhang (MOE: Chinese Ministry of Education)H-Index: 1
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Diabetic kidney disease (DKD) is the leading cause of end-stage renal failure, but therapeutic options for nephroprotection are limited. Oxidative stress plays a key role in the pathogenesis of DKD. Our previous studies demonstrated that tetramethylpyrazine nitrone (TBN), a novel nitrone derivative of tetramethylpyrazine with potent free radical-scavenging activity, exerted multifunctional neuroprotection in neurological diseases. However, the effect of TBN on DKD and its underlying mechanisms o...
#1Chunhui Huang (JNU: Jinan University)H-Index: 1
#2Jun Li (JNU: Jinan University)
Last. Sen Yan (JNU: Jinan University)H-Index: 14
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Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are serious neurodegenerative diseases. Although their pathogenesis is unclear, the abnormal accumulation of TAR DNA-binding protein of 43 kDa (TDP-43) is a pathological feature that exists in almost all patients. Thus far, there is no drug that can cure ALS/FTLD. Tetramethylpyrazine nitrone (TBN) is a derivative of tetramethylapyrazine, derived from the traditional Chinese medicine Ligusticum chuanxiong, which has ...
#1Caipeng Xie (JNU: Jinan University)H-Index: 1
#2Jingxiong Luo (JNU: Jinan University)H-Index: 3
Last. Luchen Shan (JNU: Jinan University)H-Index: 12
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Myocardial ischemia/reperfusion injury (MIRI) is an inevitable and unsolved clinical problem in the treatment of ischemic heart diseases. Compound DT-010 is a novel danshensu/tetramethylpyrazine derivative and was examined as a candidate for treating MIRI. In the present study, MTT, lactate dehydrogenase assay and Hoechst staining data indicated that DT-010 attenuated tert-butylhydroperoxide (t-BHP)-induced oxidative damage by increasing cell survival, reducing cell damage and decreasing apoptos...
1 CitationsSource
#1Zheng Liu (PolyU: Hong Kong Polytechnic University)H-Index: 1
#2Xiaoling Qiu (JNU: Jinan University)H-Index: 1
Last. Yifan Han (PolyU: Hong Kong Polytechnic University)H-Index: 50
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Abstract Alzheimer's disease (AD), characterized by impairment of cognitive functions, mainly affects the elderly worldwide. We have previously designed and synthesized a series of memantine nitrate derivatives with vessel dilatory effects. Some of novel compounds have shown neuroprotective effects; however, the detailed mechanisms have not been elucidated. In this study, we further demonstrated that memantine nitrate-06 (MN-06), one of the novel compounds derived from memantine, possessed signi...
3 CitationsSource
#1Nan Jiang (JNU: Jinan University)
#2Yuke Wei (JNU: Jinan University)
Last. Lipeng Xu (JNU: Jinan University)H-Index: 10
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Abstract Aims This study was to assess whether andrographolide derivative (AL-1) could restore mucosal homeostasis and regulate tight junctions through MLCK-dependent pathway in DSS-induced colitis mice. Main methods Colitis mice model was induced by daily administration of 2.5% DSS for seven days. The therapeutic effect was determined by evaluating the histopathological changes and the pro-inflammatory cytokine level. In addition, the effects of AL-1 on tight junctions were examined by immunohi...
#1Shinghung Mak (PolyU: Hong Kong Polytechnic University)H-Index: 15
#2Zheng Liu (FOSU: Foshan University)H-Index: 3
Last. Zaijun ZhangH-Index: 22
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We have previously designed and synthesized a series of novel memantine nitrates and some of them have shown neuroprotective effects; however, the detail mechanisms remain unknown. In this study, we demonstrated that MN-12, one of the memantine nitrates, concentration-dependently protected against glutamate-induced neurotoxicity in rat primary cultured cerebellar granule neurons (CGNs). Western blotting assays revealed that MN-12 might possess neuroprotective effects through the inhibition of ER...
2 CitationsSource
#1Hefeng Zhou (UM: University of Macau)H-Index: 8
#2Min ShaoH-Index: 2
Last. Simon Ming-Yuen Lee (UM: University of Macau)H-Index: 61
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Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), and there is no cure for it at present. We have previously reported that the tetramethylpyrazine (TMP) derivative T-006 exhibited beneficial effects in Alzheimer’s disease (AD) models. However, its effect on PD remains unclear. In the present study, we investigated the neuroprotective effects and underlying mechanisms of T-006 agains...
6 CitationsSource
#1Fangcheng Luo (JNU: Jinan University)H-Index: 2
#2Liangmiao Wu (JNU: Jinan University)H-Index: 4
Last. Zaijun Zhang (JNU: Jinan University)H-Index: 22
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BACKGROUND AND PURPOSE: Cerebral vasospasm and neuronal apoptosis after subarachnoid haemorrhage (SAH) is the major cause of morbidity and mortality in SAH patients. So far, single-target agents have not prevented its occurrence. Memantine, a non-competitive NMDA re3ceptor antagonist, is known to alleviate brain injury and vasospasm in experimental models of SAH. Impairment of NO availability also contributes to vasospasm. Recently, we designed and synthesized a memantine nitrate MN-08, which ha...
4 CitationsSource
#1Hefeng Zhou (UM: University of Macau)H-Index: 8
#2Min ShaoH-Index: 2
Last. Simon Ming-Yuen Lee (UM: University of Macau)H-Index: 61
view all 14 authors...
Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide and is characterized in part by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). The main pathological hallmark of PD is the intraneuronal accumulation of misfolded α-synuclein (α-syn) aggregates. Mutations in the SNCA gene (encoding α-syn) and variations in its copy number are associated with some forms of familial PD. In the present study, T-006, a new tetramethylpyrazin...
8 CitationsSource
#1Xinhua Zhou (UM: University of Macau)H-Index: 6
#2Anqi Wang (UM: University of Macau)H-Index: 12
Last. Yuqiang Wang (JNU: Jinan University)H-Index: 25
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Background: We previously demonstrated that a Danshensu-Tetramethylpyrazine conjugate DT-010 enhanced anticancer effect of doxorubicin (Dox) in Dox-sensitive human breast cancer cells, and protected against Dox-induced cardiotoxicity. This work was designed to see whether DT-010 overcomes Dox resistance in resistant human breast cancer cells. Methods: The effects of DT-010, Dox or their combination on cell viability of Dox-resistant human breast cancer MCF-7/ADR cells were conducted using MTT as...
6 CitationsSource