Bohang Sun
Shenyang Pharmaceutical University
TriterpenoidCytotoxicityBiological activityProtein Data BankStereoisomerismMolecular biologyPharmacognosyChemical structureOrganic chemistryEnzymeChemistryHeteronuclear single quantum coherence spectroscopyGlycosideTwo-dimensional nuclear magnetic resonance spectroscopyTerpenoidAbsolute configurationSalaciaSesquiterpeneFagopyrum tataricumAcarboseDiterpeneCurcumaHeLaAlpha-glucosidaseLanostaneTalaromycesFlavonoidButyrylcholinesteraseMedicinal plantsGinsengAglyconeDiscovery StudioFungusDammaraneEthyl acetateLanosterolIsocoumarinTriterpeneTaxus cuspidataIsocoumarinsAbies sachalinensisPULMONARY CARCINOMAAbiesanolide CTalaromyces flavusSpectral analysisChemical constituentsPositive controla glucosidaseMass spectrumTerpeneAntimicrobialBacteriaEnzymatic hydrolysisBiochemistryTraditional medicineBotanyProtein Data Bank (RCSB PDB)Nuclear magnetic resonance spectroscopyStereochemistryCell cultureBiology
10Publications
4H-index
43Citations
Publications 10
Newest
#1Junwei He (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 8
#2Huai-Shuang Xu (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Guoyue Zhong (JUTCM: Jiangxi University of Traditional Chinese Medicine)H-Index: 6
view all 9 authors...
: Two new isocoumarin derivatives, talaisocoumarins A (1) and B (2), and three new related metabolites, talaflavuols A-C (3-5) were isolated from the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic (NMR) and MS analyses. The absolute configurations of 1 and 2 were determined by CD and an Rh2(OCOCF3)4-induced CD method. All compounds were evaluated for cytotoxic and antimicrobial activities. However, none of them showed any activity. The ...
3 CitationsSource
#1Hui-Qi GeH-Index: 1
#2Guo-Sheng Wan (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 7 authors...
AbstractTwo new isoxazoline compounds, 1-oxa-2-azaspiro[4.5]dec-2-ene-8β-ol (1) and 1-oxa-2-azaspiro[4.5]dec-2-ene-8α-ol (2), were isolated from the husks of fruits of Xanthoceras sorbifolia Bunge and their structures were determined by spectroscopic analyses, including X-ray crystallography, HRESI-MS, UV, IR, and 1D and 2D NMR (HSQC, HMBC, NOESY) methods. Neither compound showed significant inhibitory effects on butyrylcholinesterase (BuchE) and acetylcholinesterase (AChE), nor the selected tum...
3 CitationsSource
#1Jian Huang (SPU: Shenyang Pharmaceutical University)H-Index: 20
#2Zhenghong Guo (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 5 authors...
Abstract To identify the chemical constituents with hypoglycemic activity in Salacia hainanensis Chun et How, this study was carried out on the roots of S. hainanensis . By means of a bioassay-guided method, three new triterpenoids (2 β ,3 β -dihydroxylup-20(29)-ene [compound 1 ], 30-hydroxy-D:A-friedo-olean-1-en-3-one [compound 2 ], and 24,25,26-trihydroxytirucall-7-en-3-one [compound 3 ]) along with three known compounds (olibanumol J [compound 4 ], 21 α -hydroxy-D:A-friedo-olean-3-one [compou...
7 CitationsSource
#1Hai-Ying Ma (PRC: China Medical University (PRC))H-Index: 2
#2Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
Last. Bo Yang (SPU: Shenyang Pharmaceutical University)H-Index: 1
view all 5 authors...
Three new triterpenoid derivatives, 3-O-β-d-glucopyranosyl-20(S)-protopanaxtriol (1), 3-formyloxy-20-O-β-d-glucopyranosyl-20(S)-protopanaxtriol (2) and 26-hydroxyl-24(E)-20(S)-protopanaxtriol (3), along with six known ginsenosides, were isolated from leaves of Panax ginseng. Their structures were established on the basis of spectral analysis (IR, 1D and 2D NMR, HRESI-MS). Compounds 1–3 exhibited various degree of cytotoxicity towards human A549 pulmonary carcinoma cells and Hep3B hepatoma cells.
8 CitationsSource
#1Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
#2Di WuH-Index: 1
Last. Li-Jun Wu (SPU: Shenyang Pharmaceutical University)H-Index: 20
view all 7 authors...
In the screening of biologically active constituents from medicinal plants, the 75% EtOH extract of the testas of Castanea mollissima Blume showed potent α-glucosidase inhibitory activity. By means of various chromatographic methods, the extract gave a new dammarane-type triterpene 1 along with 17 known compounds. The structure of 1 was determined to be 3β-acetoxy-20-oxo-21-nordammaran-23-oic acid by HRMS and NMR studies including 2D NMR experiments. The new compound and some known compounds sho...
9 CitationsSource
#1Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
#2Xiao-bo WangH-Index: 4
Last. Li-Jun Wu (SPU: Shenyang Pharmaceutical University)H-Index: 20
view all 6 authors...
: From the nuts of Castanea mollissima Blume, a new kauranoid diterpene glycoside, named mollioside (1), was isolated. Its structure was established as (4R, 5S, 6R, 8R, 9S, 10S, 13R, 16R) 17-O-beta-D-glucopyranoside, ent-6,7-epoxy-6alpha-hydroxyl-6,7-secokaur-19-oic acid, 6, 19-lactone-16beta, 17-diol on the basis of HR-FAB-MS, 1D, 2D-NMR and CD spectral analysis. The aglycone (1a, named mollissin), also as a new compound, was obtained after enzymatic hydrolysis of 1. Both compounds exhibited si...
1 CitationsSource
#1Bohang Sun (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Bailing Hou (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Huiyuan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 12
view all 6 authors...
Further chemical study led to two new A-seco-rearranged lanostane triterpenoid derivatives (1–2) and one known compound Abiesanolide C (3) from the ethyl acetate (EtOAc) soluble fraction of the MeOH extract of Abies sachalinensis needles. The new compounds were identified as 3,4-seco-8-(14→13R)abeo-17,13-friedo-9β-lanosta-4(28), 7, 14, 24-tetraen-26,23-olide-23-hydroxy-3-oic acid and methyl-3,4-seco-8-(14→13R) abeo-17,13-friedo-9β-lanosta-4(28), 7, 14, 24-tetraen-26,23-olide-23-hydroxy-3-oate, r...
3 CitationsSource
#1Yongyi WangH-Index: 1
#2Jian HuangH-Index: 20
Last. Lijun WuH-Index: 2
view all 6 authors...
1 Citations
#1Yaqing WuH-Index: 1
#2Bohang SunH-Index: 4
Last. Lijun WuH-Index: 2
view all 5 authors...
3 Citations
#1Chunyan LiuH-Index: 2
#2Bohang SunH-Index: 4
Last. Lijun WuH-Index: 2
view all 6 authors...
5 Citations