Guowen Liu
Jilin University
Internal medicineEndocrinologyProinflammatory cytokineChemistryIn vitroOxidative stressKetosisFatty liverNEFALipid metabolismFatty acid synthaseFatty acidBiochemistryOxidative phosphorylationSignal transductionVery low-density lipoproteinBiologyCell biologyProtein kinase APharmacology
129Publications
27H-index
2,279Citations
Publications 123
Newest
#1Miao LongH-Index: 16
#1Miao LongH-Index: 1
Last. Guo-Wen LiuH-Index: 1
view all 6 authors...
This study was conducted to determine if adding the acid-tolerant engineered bacterial strain M. elsdenii H6F32 to the rumen of sheep would reduce the risk of lactic acidosis. Lactic acidosis were induced by feed challenges in three groups of six sheep intraruminally dosed with wheat. In each group, sheep were not supplemented(C) or supplemented with the original bacterial strain M.elsdenii H6(H6) or the acid-tolerant engineered bacterial strain M.elsdenii H6F32(H6F32). Compared with C, the conc...
3 CitationsSource
#1Xiaojing Xia (JLU: Jilin University)H-Index: 11
#2Yanyi Che (JLU: Jilin University)H-Index: 7
Last. Liancheng LeiH-Index: 19
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During the lactation cycle of the bovine mammary gland, autophagy is induced in bovine mammary epithelial cells (BMECs) as a cellular homeostasis and survival mechanism. Interferon gamma (IFN-γ) is an important antiproliferative and apoptogenic factor that has been shown to induce autophagy in multiple cell lines in vitro. However, it remains unclear whether IFN-γ can induce autophagy and whether autophagy affects milk synthesis in BMECs. To understand whether IFN-γ affects milk synthesis, we is...
16 CitationsSource
#1Xiaojing Xia (JLU: Jilin University)H-Index: 11
#2Yanyi Che (JLU: Jilin University)H-Index: 7
Last. Liancheng Lei (JLU: Jilin University)H-Index: 19
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Diet-driven interferon- γ enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy
6 CitationsSource
#1Tong Xu (JLU: Jilin University)H-Index: 1
#2Xuejiao Gao (JLU: Jilin University)H-Index: 13
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
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The interactions between the essential element selenium (Se) and the toxic element lead (Pb) have been reported extensively; however, limited data are available regarding the effects of Se on Pb and the ion profile in chicken liver. Whether the change in the ion profile was involved in the protective process of Se and the toxic effect of Pb is unknown. In the present study, we detected 26 ion profiles (including those of Na, Mg, K, Ca, B, Si, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Se, Mo, Sb, Ba, Tl, Li...
39 CitationsSource
#1Yu Li (AAU: Anhui Agricultural University)H-Index: 11
#2Hongyan Ding (AAU: Anhui Agricultural University)H-Index: 7
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
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Elevated levels of blood interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor–α (TNF–α) increase insulin resistance and result in inflammation. It is not clear whether elevated blood level of acetoacetate (ACAC) and decreased blood level of glucose, which are the predominant characteristics of clinical biochemistry in ketotic dairy cows, increase proinflammatory cytokines and subsequent inflammation. The objective of this study was to test the hypothesis that ACAC and glucose ...
12 CitationsSource
#1Xinwei Li (JLU: Jilin University)H-Index: 23
#2Yuan Guan (JLU: Jilin University)H-Index: 8
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
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Abstract Fatty liver is a major metabolic disorder of dairy cows. One important reason is that hepatic very low-density lipoproteins (VLDL) assembly was significant decreased in dairy cows with fatty liver. In addition, the impairment of insulin-like growth factor (IGF)-1 synthesis was involved in the development of fatty liver. Therefore, the objective of this study was to investigate the effects of IGF-1 on the VLDL assembly in cow hepatocytes. In this study, cow hepatocytes were cultured and ...
1 CitationsSource
#1Chuang XuH-Index: 8
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Wei YangH-Index: 4
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When abrin-a was combined with several polyclonal antibodies (PAb), the detection limit could be increased. In this way, a monoclonal antibody (capture) and polyclonal antibody (detection) sandwich enzyme-linked immunosorbent assay (ELISA) and a colloidal gold-PAb conjugate-based immunochromatographic assay for detection of abrin-a were developed. The ELISA had a detection limit of 3.9 ng/mL for abrin-a in standard solution and 7.8 ng/mL in soybean milk, and was more sensitive than polyclonal an...
6 CitationsSource
#1Xinwei Li (JLU: Jilin University)H-Index: 23
#2Weikun Huang (JLU: Jilin University)H-Index: 1
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
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Dairy cows with fatty liver are characterized by hepatic lipid accumulation and a severe inflammatory response. Sterol receptor element binding protein-1c (SREBP-1c) and nuclear factor κB (NF-κB) are components of the main pathways for controlling triglyceride (TG) accumulation and inflammatory levels, respectively. A previous study demonstrated that hepatic inflammatory levels are positively correlated with hepatic TG content. We therefore speculated that SREBP-1c might play an important role i...
78 CitationsSource
#1Qinghua Deng (JLU: Jilin University)H-Index: 8
#2Guowen Liu (JLU: Jilin University)H-Index: 27
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
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β-hydroxybutyric acid (BHBA), an important metabolite in β-oxidation, is involved in the development of ketosis in dairy cows. It is known that AMP-activated protein kinase (AMPK) signaling pathway plays an important role in the regulation of lipid metabolism in hepatocytes. In the present study, bovine hepatocytes were treated with BHBA at variable concontrations and Compound C (Cpd C, an AMPK inhibitor) to investigate the effects of BHBA on the AMPK signaling pathway. The results showed that w...
19 CitationsSource
#1Xinwei Li (JLU: Jilin University)H-Index: 23
#2Guowen Liu (JLU: Jilin University)H-Index: 27
Last. Xiaoxia Shi (JLU: Jilin University)H-Index: 8
view all 3 authors...