Guowen Liu
Jilin University
Internal medicineEndocrinologyProinflammatory cytokineChemistryIn vitroOxidative stressKetosisFatty liverNEFALipid metabolismFatty acid synthaseFatty acidBiochemistryOxidative phosphorylationSignal transductionVery low-density lipoproteinBiologyCell biologyProtein kinase APharmacology
129Publications
27H-index
2,279Citations
Publications 123
Newest
#1Z. G. ZhangH-Index: 1
#2J. D. XueH-Index: 1
Last. Z. WangH-Index: 1
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Received: Revised: Accepted: July 24, 2012 November 17, 2012 December 07, 2012 Ketosis is a major disease related with negative energy balance and immune suppression in dairy cows. The objective of this study was to examine the differences in β-hydroxybutyrate (BHBA), L-selectin, glucose, tumor necrosis factor-α (TNF-α), non-esterified fatty acids (NEFA), and sialic acid (SA) concentrations in serum in healthy dairy cows and those with subclinical ketosis during the early lactation period. The b...
3 Citations
#1Miao LongH-Index: 16
#1Miao LongH-Index: 1
Last. Xiaobing LiH-Index: 1
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The objective of this study was to determine the effects of six yeast (Saccharomyces cerivisiae, Candida tropicalis, Pichia burtonii, Candida utilis, Rhodothece glutinis, Geotrichum candidum) on lactate utilization by the predominant ruminal bacterium Selenomonas ruminantium(S. ruminantium). Four different concentration of these yeasts (6g/l, 8g/l, 10g/l, 12g/l) and non-yeast control group were set. The pH and the concentration of lactate, acetate, and propionate in the culture fluids were detec...
1 Citations
#1Peng Li (Shenyang Agricultural University)H-Index: 14
#2Yiming LiuH-Index: 1
Last. Guowen LiuH-Index: 27
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Background: NEFA plays numerous roles in the metabolism of glucose, lipids, and proteins. A number of experimental studies have shown that NEFA may have an important role in fatty acid metabolism in the liver, especially in dairy cows that experience negative energy balance (NEB) during early lactation. Methods: In this study, using fluorescent quantitative RT-PCR, ELISA, and primary hepatocytes cultured in vitro, we examined the effect of NEFA (0, 0.2, 0.4, 0.8, 1.6, and 3.2 mmol/L) on fatty ac...
18 CitationsSource
#1Miao LongH-Index: 1
#2Peng LiH-Index: 14
Last. Guowen LiuH-Index: 27
view all 7 authors...
14 CitationsSource
#1Wenyan Yang (JLU: Jilin University)H-Index: 2
#2Jianguo Wang (JLU: Jilin University)H-Index: 10
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
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This experiment was conducted to examine the effect of dietary copper supplementation on ghrelin mRNA expression level in the fundic gland of growing pigs. A total of 45 crossbred pigs were randomly assigned to three groups of 15 pigs, five replicates of three animals comprised each group. Pigs were allocated to diets that contained 5 mg/kg copper (as the control group), 125 mg/kg copper sulfate, or 125 mg/kg copper methionine. At the end of the experiment, five pigs were selected at random from...
11 CitationsSource
#1Guanghong Xie (JLU: Jilin University)H-Index: 9
#2Na ChenH-Index: 16
Last. Guowen LiuH-Index: 27
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The objective of this study was to test the hypothesis that p-cymene can attenuate acute lung injury induced by lipopolysaccharide (LPS) in vivo. In the mouse model of LPS-induced acute lung injury, intraperitoneal preconditioning with p-cymene resulted in a significant reduction of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), lung water gain, inflammatory cell infiltration, lung tissue myeloperoxidase activity. In addition, p-cymene blocked the phosphorylation of IκBα protein and mitogen...
30 CitationsSource
#1Chen-Chen Wu (JLU: Jilin University)H-Index: 3
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Shizheng GaoH-Index: 1
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Red-colored bones were found initially in some Guishan goats in the 1980s, and they were designated red-boned goats. However, it is not understood what causes the red color in the bone, or whether the red material changes the bone geometry, architecture, and metabolism of red-boned goats. Pseudopurpurin was identified in the red-colored material of the bone in red-boned goats by high-performance liquid chromatography–electrospray ionization–mass spetrometry and nuclear magnetic resonance analysi...
2 CitationsSource
#1Chen-Chen Wu (JLU: Jilin University)H-Index: 3
#2Jianguo Wang (JLU: Jilin University)H-Index: 10
Last. Shizheng GaoH-Index: 1
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Red-colored bones were first found in Guishan goats in the 1980s, and they were subsequently designated red-boned Guishan goats. However, the difference remains unclear between the bone mineral density (BMD) or elemental composition in bones between red-boned Guishan goats and common Guishan goats. Analysis of femoral bone samples by dual-energy X-ray absorptiometry and inductively coupled plasma optical emission spectrometry revealed an increase in bone mineral density in the femoral diaphysis ...
1 CitationsSource
#1Xiaoxu Wang (JLU: Jilin University)H-Index: 4
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Zhe Wang (JLU: Jilin University)H-Index: 26
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The transition period is a severe challenge to dairy cows. Glucose supply cannot meet demand and body fat is mobilized, potentially leading to negative energy balance (NEB), ketosis, or fatty liver. Propionate produces glucose by gluconeogenesis, which depends heavily on the number and species of microbes. In the present study, we analyzed the rumen microbiome composition of cows in the transition period, cows with ketosis, and nonperinatal cows by terminal restriction fragment length polymorphi...
59 CitationsSource
#1Chen-Chen WuH-Index: 3
#2Xiaobing LiH-Index: 22
Last. Zhe WangH-Index: 26
view all 7 authors...
The objective of our study was to evaluate whether feeding pseudopurpurin affects bone mineral density and bone geometry architecture in rats. Pseudopurpurin was extracted, analyzed and purified using an HLPC-ESI-MS. Rats were given 0% and 0.5% pseudopurpurin powder in their diet. Femurs of rats were examined at 0.5, 1 and 2 months after pseudopurpurin feeding. Compared with rats in the group 0%, the bone mineral density, and the calcium, magnesium, zinc and manganese concentrations in the rats ...
3 CitationsSource