Minh-Phuong Huynh-Le
George Washington University
Internal medicineRadiologyGenotypeOncologyDemographyLogistic regressionSingle-nucleotide polymorphismNeurocognitiveHazard ratioChemotherapyBrachytherapyBrain tumorAnal cancerProstate cancerWhite matterNuclear medicineProportional hazards modelRadiation therapyMedicineCohortGenetic genealogy
68Publications
10H-index
255Citations
Publications 64
Newest
#1Minh-Phuong Huynh-Le (UCSD: University of California, San Diego)H-Index: 10
#2Roshan Karunamuni (UCSD: University of California, San Diego)H-Index: 15
Last. Artitaya Lophatananon (University of Manchester)H-Index: 31
view all 78 authors...
Abstract null Introduction null Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs in a prostate cancer polygenic hazard score (PHS) would improve associations with clinically significant prostate cancer in multi-ancestry datasets. null Methods null In total, 299 SNPs previously as...
1 CitationsSource
#1Mia A Salans (UCSD: University of California, San Diego)H-Index: 3
#2Michelle D. Tibbs (UCSD: University of California, San Diego)H-Index: 4
Last. Jona A. Hattangadi-Gluth (UCSD: University of California, San Diego)H-Index: 23
view all 10 authors...
BACKGROUND We explored fine motor skills (FMS) before and after brain radiotherapy (RT), analyzing associations between longitudinal FMS and imaging biomarkers of cortical and white matter (WM) integrity in motor regions of interest (ROIs). METHODS On a prospective trial, 52 primary brain tumor patients receiving fractionated brain RT underwent volumetric brain MRI, diffusion tensor imaging, and FMS assessments (Delis-Kaplan Executive Function System Trail Making Test Motor Speed [DKEFS-MS], Gro...
2 CitationsSource
#47Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
#48Tyler M. Seibert (UCSD: University of California, San Diego)H-Index: 18
We previously developed an African-ancestry-specific polygenic hazard score (PHS46+African) that substantially improved prostate cancer risk stratification in men with African ancestry. The model consists of 46 SNPs identified in Europeans and 3 SNPs from 8q24 shown to improve model performance in Africans. Herein, we used principal component (PC) analysis to uncover subpopulations of men with African ancestry for whom the utility of PHS46+African may differ. Genotypic data were obtained from PR...
2 CitationsSource
#1Mia A Salans (UCSD: University of California, San Diego)H-Index: 3
#2Michelle D. Tibbs (UCSD: University of California, San Diego)H-Index: 4
Last. Tonya M. Pan-Weisz (UCSD: University of California, San Diego)H-Index: 3
view all 12 authors...
ABSTRACT null null Background null We conducted the first prospective longitudinal study examining the independent association between patient-reported hrQoL (physical, social/family, emotional, functional, and brain cancer-specific) and neurocognitive function (NCF), while controlling for mood symptoms in primary brain tumor patients. null null null Methods null Primary brain tumor patients (n=59) receiving brain radiotherapy (RT) underwent hrQOL (Functional Assessment of Cancer Therapy-Brain),...
Source
#1Mia A Salans (UCSD: University of California, San Diego)H-Index: 3
#2Michelle D. Tibbs (UCSD: University of California, San Diego)H-Index: 4
Last. Jona A. Hattangadi-Gluth (UCSD: University of California, San Diego)H-Index: 23
view all 4 authors...
Source
#1Vitali Moiseenko (UCSD: University of California, San Diego)H-Index: 32
#2Jona A. Hattangadi-Gluth (UCSD: University of California, San Diego)H-Index: 23
Last. Issam El NaqaH-Index: 58
view all 10 authors...
Source
#1Sindhu Kubendran (GW: George Washington University)H-Index: 1
#2Erica Schockett (GW: George Washington University)H-Index: 1
Last. Sharad Goyal (GW: George Washington University)H-Index: 11
view all 8 authors...
INTRODUCTION Primary brain malignancies (PBMs) pose significant morbidity and poor prognosis. Despite NCCN recommendations that palliative care should be integrated into general oncologic care plans, it has been historically underused in patients with PBM. We sought to examine trends and factors associated with inpatient palliative care use in patients with PBM. METHODS Data from the 2007-2016 National (Nationwide) Inpatient Sample was analyzed for descriptive statistics and trends. Multivariabl...
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#1Vitali Moiseenko (UCSD: University of California, San Diego)H-Index: 32
#2Lawrence B. Marks (UNC: University of North Carolina at Chapel Hill)H-Index: 90
Last. Issam El NaqaH-Index: 58
view all 10 authors...
An overview of common approaches used to assess a dose response for radiation therapy-associated endpoints is presented, using lung toxicity data sets analyzed as a part of the High Dose per Fraction, Hypofractionated Treatment Effects in the Clinic effort as an example. Each component presented (eg, data-driven analysis, dose-response analysis, and calculating uncertainties on model prediction) is addressed using established approaches. Specifically, the maximum likelihood method was used to ca...
2 CitationsSource
#1Minh-Phuong Huynh-Le (GW: George Washington University)H-Index: 10
#2Roshan Karunamuni (UCSD: University of California, San Diego)H-Index: 15
Last. Tyler M. Seibert (UCSD: University of California, San Diego)H-Index: 18
view all 13 authors...
BACKGROUND Clinical variables-age, family history, genetics-are used for prostate cancer risk stratification. Recently, polygenic hazard scores (PHS46, PHS166) were validated as associated with age at prostate cancer diagnosis. While polygenic scores are associated with all prostate cancer (not specific for fatal cancers), PHS46 was also associated with age at prostate cancer death. We evaluated if adding PHS to clinical variables improves associations with prostate cancer death. METHODS Genotyp...
3 CitationsSource