Wesley K. Thompson
University of California, San Diego
Genome-wide association studyPsychiatryInternal medicineDevelopmental psychologySingle-nucleotide polymorphismPsychologyHeritabilityNeuroscienceCognitionGenetic associationBipolar disorderDiseaseComputer scienceGeneticsNeuroimagingClinical psychologyMedicineCohortBiologyGenetic architecture
Publications 291
#1Martin P. Paulus (UCSD: University of California, San Diego)H-Index: 107
#2Lindsay M. Squeglia (MUSC: Medical University of South Carolina)H-Index: 29
Last. Susan F. Tapert (UCSD: University of California, San Diego)H-Index: 88
view all 11 authors...
Abstract The adolescent brain undergoes profound structural changes which is influenced by many factors. Screen media activity (SMA; e.g., watching television or videos, playing video games, or using social media) is a common recreational activity in children and adolescents; however, its effect on brain structure is not well understood. A multivariate approach with the first cross-sectional data release from the Adolescent Brain Cognitive Development (ABCD) study was used to test the maturation...
36 CitationsSource
#1Wesley K. Thompson (UCSD: University of California, San Diego)H-Index: 68
#2Ole A. Andreassen (University of Oslo)H-Index: 123
Last. Yunpeng Wang (University of Oslo)H-Index: 34
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Abstract Modern medical bioinformatics encompasses a vast number of possible markers potentially useful for diagnosis. These markers may include structured clinical interviews, self-report questionnaires, inflammatory markers, multi-modal brain imaging (both structural and functional), and whole-genome genotyping. The number of possible individual inputs is thus in the hundreds or many thousands, and the factorial combination of such markers is even more vast. Moreover, some markers are easy and...
#1Sonja LaBiancaH-Index: 1
#2Vivek AppaduraiH-Index: 11
Last. Alfonso BuilH-Index: 34
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#1Oleksandr Frei (University of Oslo)H-Index: 19
#2Olav B. Smeland (Oslo University Hospital)H-Index: 22
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
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Background Identifying shared genetics is important as it uncovers hidden relationship between complex traits and improves our understanding of disease etiology. Today genetic correlation is commonly used as the principal measure that quantifies genetic overlap. Available methods can calculate genetic correlation from raw genotypes (restricted maximum likelihood, polygenic risk scores), from a set of Single-Nucleotide Polymorphisms (SNPs) that pass genome-wide significance threshold (Mendelian R...
#1Darina CzamaraH-Index: 14
#1Darina CzamaraH-Index: 30
Last. Patrick F. SullivanH-Index: 144
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#1Lene AarøeH-Index: 13
#2Vivek AppaduraiH-Index: 11
Last. Michael Bang PetersenH-Index: 33
view all 8 authors...
#1Dan Li (SC: University of Southern California)H-Index: 7
#2Samuel Iddi (SC: University of Southern California)H-Index: 10
Last. Michael C. Donohue (SC: University of Southern California)H-Index: 48
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Abstract Introduction Clinical trials on preclinical Alzheimer’s disease are challenging because of the slow rate of disease progression. We use a simulation study to demonstrate that models of repeated cognitive assessments detect treatment effects more efficiently than models of time to progression. Methods Multivariate continuous data are simulated from a Bayesian joint mixed-effects model fit to data from the Alzheimer’s Disease Neuroimaging Initiative. Simulated progression events are algor...
3 CitationsSource
#1Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
#2John J. McGrath (Centre for Mental Health)H-Index: 134
Last. Carsten Bøcker PedersenH-Index: 69
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Spatial mapping is a promising strategy to investigate the mechanisms underlying the incidence of psychosis. We analyzed a case-cohort study (n = 24,028), drawn from the 1.47 million Danish persons born between 1981 and 2005, using a novel framework for decomposing the geospatial risk for schizophrenia based on locale of upbringing and polygenic scores. Upbringing in a high environmental risk locale increases the risk for schizophrenia by 122%. Individuals living in a high gene-by-environmental ...
6 CitationsSource
#1Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 88
#2Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 22
Last. Anders M. Dale (UC: University of California)H-Index: 166
view all 142 authors...
The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects of environmental influences on behavioral and brain development in adolescents. The ABCD Study is a collaborative effort, including a Coordinating Center, 21 data acquisition sites across the United States, and a Data Analysis and Informatics Center (DAIC). The main objective of the study is to recruit and assess over eleven thousand 9-10-year-olds and follow them over the course of 10 years to...
21 CitationsSource