Wesley K. Thompson
University of California, San Diego
Genome-wide association studyPsychiatryInternal medicineDevelopmental psychologySingle-nucleotide polymorphismPsychologyHeritabilityNeuroscienceCognitionGenetic associationBipolar disorderDiseaseComputer scienceGeneticsNeuroimagingClinical psychologyMedicineCohortBiologyGenetic architecture
Publications 291
#1Heekyeong Park (McGovern Institute for Brain Research)
#2Katherine L. Forthman (McGovern Institute for Brain Research)H-Index: 3
Last. Martin P. Paulus (McGovern Institute for Brain Research)H-Index: 107
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Abstract null null Background null Neuroticism is a heritable trait that contributes to the vulnerability to depression. We used polygenic risk scores (PRS) to examine genetic vulnerability to neuroticism and its associations with reward/punishment processing in a clinical sample with mood, anxiety, and substance use disorders. It was hypothesized that higher PRS for neuroticism is associated with attenuated neural responses to reward/punishment. null null null Method null Four hundred sixty-nin...
#1Clare E. Palmer (UCSD: University of California, San Diego)H-Index: 11
#2Chandni Sheth (UofU: University of Utah)H-Index: 7
Last. Marybel Robledo Gonzalez (UCSD: University of California, San Diego)H-Index: 4
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Physical health in childhood is crucial for neurobiological as well as overall development, and can shape long-term outcomes into adulthood. The landmark, longitudinal Adolescent Brain Cognitive Development StudySM (ABCD study), was designed to investigate brain development and health in almost 12,000 youth who were recruited when they were 9-10 years old and will be followed through adolescence and early adulthood. The overall goal of this paper is to provide descriptive analyses of physical he...
#1Anthony Steven Dick (FIU: Florida International University)H-Index: 21
#2Daniel A Lopez (URMC: University of Rochester Medical Center)H-Index: 2
Last. Andrew T. Marshall (SC: University of Southern California)H-Index: 14
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Abstract null null The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n= 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, e...
3 CitationsSource
#1Se Jin Song (UCSD: University of California, San Diego)H-Index: 34
#2Jincheng Wang (RU: Rutgers University)H-Index: 2
Last. Caroll Hernández (UC: Pontifical Catholic University of Chile)H-Index: 4
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Summary null null Background null Early microbiota perturbations are associated with disorders that involve immunological underpinnings. Cesarean section (CS)-born babies show altered microbiota development in relation to babies born vaginally. Here we present the first statistically powered longitudinal study to determine the effect of restoring exposure to maternal vaginal fluids after CS birth. null null null Methods null Using 16S rRNA gene sequencing, we followed the microbial trajectories ...
#1Christopher N. Kaufmann (UF: University of Florida)
#2Mark W. Bondi (UCSD: University of California, San Diego)H-Index: 71
Last. Atul Malhotra (UCSD: University of California, San Diego)H-Index: 110
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BACKGROUND Sleep disturbances are associated with risk of cognitive decline but it is not clear if treating disturbed sleep mitigates decline. We examined differences in cognitive trajectories before and after sleep treatment initiation. METHODS Data came from the 2006-2014 Health and Retirement Study. At each of five waves, participants were administered cognitive assessments and scores were summed. Participants also reported if, in prior two weeks, they had taken medications or used other trea...
#1Ron Nudel (CMHS: Mental Health Services)H-Index: 3
#1Ron Nudel (CMHS: Mental Health Services)H-Index: 9
Last. Michael E. Benros (Lundbeck)H-Index: 32
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BACKGROUND Infections are a major disease burden worldwide. While they are caused by external pathogens, host genetics also plays a part in susceptibility to infections. Past studies have reported diverse associations between human leukocyte antigen (HLA) alleles and infections, but many were limited by small sample sizes and/or focused on only one infection. METHODS We performed an immunogenetic association study examining 13 categories of severe infection (bacterial, viral, central nervous sys...
#1Cortney Simmons (Yale University)H-Index: 5
#2May I. Conley (Yale University)H-Index: 3
Last. B. J. Casey (Yale University)H-Index: 107
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#1Xueping Liu (Centre for Mental Health)H-Index: 6
#1Xueping Liu (Centre for Mental Health)H-Index: 1
Last. Michael E. Benros (Centre for Mental Health)H-Index: 32
view all 15 authors...
1 CitationsSource
#1Ty BrumbackH-Index: 15
#2Wesley K. ThompsonH-Index: 68
Last. Susan F. TapertH-Index: 88
view all 5 authors...
Many psychosocial factors have been implicated in the onset and escalation of substance use in adolescence and young adulthood. Typically, each factor explains a small amount of the variance in substance use outcomes, and effects are typically applied across a broad range of ages or computed from cross-sectional data. The current study evaluated the association of factors including social influence (e.g., peer substance use), cognitive features (e.g., alcohol expectancies), and personality and e...
#1Sergio Picart-Armada (UPC: Polytechnic University of Catalonia)H-Index: 5
#2Wesley K. ThompsonH-Index: 68
Last. Alexandre Perera-Lluna (UPC: Polytechnic University of Catalonia)H-Index: 12
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MOTIVATION Network diffusion and label propagation are fundamental tools in computational biology, with applications like gene-disease association, protein function prediction and module discovery. More recently, several publications have introduced a permutation analysis after the propagation process, due to concerns that network topology can bias diffusion scores. This opens the question of the statistical properties and the presence of bias of such diffusion processes in each of its applicati...