Wesley K. Thompson
University of California, San Diego
Genome-wide association studyPsychiatryInternal medicineDevelopmental psychologySingle-nucleotide polymorphismPsychologyHeritabilityNeuroscienceCognitionGenetic associationBipolar disorderDiseaseComputer scienceGeneticsNeuroimagingClinical psychologyMedicineCohortBiologyGenetic architecture
Publications 290
#1Ron Nudel (CMHS: Mental Health Services)H-Index: 3
Last. Michael E. Benros (Lundbeck)H-Index: 30
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BACKGROUND Infections are a major disease burden worldwide. While they are caused by external pathogens, host genetics also plays a part in susceptibility to infections. Past studies have reported diverse associations between human leukocyte antigen (HLA) alleles and infections, but many were limited by small sample sizes and/or focused on only one infection. METHODS We performed an immunogenetic association study examining 13 categories of severe infection (bacterial, viral, central nervous sys...
#1Cortney Simmons (Yale University)H-Index: 5
#2May I. Conley (Yale University)H-Index: 3
Last. B. J. Casey (Yale University)H-Index: 108
view all 14 authors...
#1Xueping Liu (Centre for Mental Health)
#2Ron Nudel (CMHS: Mental Health Services)H-Index: 3
Last. Michael E. Benros (Centre for Mental Health)H-Index: 30
view all 15 authors...
#1Delin Sun (Duke University)H-Index: 11
#2Viraj Adduru (RIT: Rochester Institute of Technology)H-Index: 5
Last. Rajendra A. Morey (Duke University)H-Index: 34
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Objective: Cortical thickness changes dramatically during development and is influenced by adolescent drinking. However, previous findings have been inconsistent and limited by region-of-interest approaches that are underpowered because they do not conform to the underlying heterogeneity from the effects of alcohol. Methods: Adolescents (n=657; 12-22 years at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) who endorsed little to no alcohol use at ba...
#1Ty BrumbackH-Index: 15
#2Wesley K. ThompsonH-Index: 71
Last. Susan F. TapertH-Index: 87
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Many psychosocial factors have been implicated in the onset and escalation of substance use in adolescence and young adulthood. Typically, each factor explains a small amount of the variance in substance use outcomes, and effects are typically applied across a broad range of ages or computed from cross-sectional data. The current study evaluated the association of factors including social influence (e.g., peer substance use), cognitive features (e.g., alcohol expectancies), and personality and e...
#1Sergio Picart-Armada (UPC: Polytechnic University of Catalonia)H-Index: 5
#2Wesley K. ThompsonH-Index: 71
Last. Alexandre Perera-Lluna (UPC: Polytechnic University of Catalonia)H-Index: 12
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MOTIVATION Network diffusion and label propagation are fundamental tools in computational biology, with applications like gene-disease association, protein function prediction and module discovery. More recently, several publications have introduced a permutation analysis after the propagation process, due to concerns that network topology can bias diffusion scores. This opens the question of the statistical properties and the presence of bias of such diffusion processes in each of its applicati...
#1Yi Li (UCSF: University of California, San Francisco)H-Index: 94
#2Wesley K. Thompson (UCSD: University of California, San Diego)H-Index: 71
Last. Sandra A. Brown (UCSD: University of California, San Diego)H-Index: 124
view all 109 authors...
Importance Incidental findings (IFs) are unexpected abnormalities discovered during imaging and can range from normal anatomic variants to findings requiring urgent medical intervention. In the case of brain magnetic resonance imaging (MRI), reliable data about the prevalence and significance of IFs in the general population are limited, making it difficult to anticipate, communicate, and manage these findings. Objectives To determine the overall prevalence of IFs in brain MRI in the nonclinical...
#1Martin P. Paulus (Yale University)H-Index: 105
#2Wesley K. Thompson (UCSD: University of California, San Diego)H-Index: 71
Rationale The impact of neuroscience-based approaches for psychiatry on pragmatic clinical decision-making has been limited. Although neuroscience has provided insights into basic mechanisms of neural function, these insights have not improved the ability to generate better assessments, prognoses, diagnoses, or treatment of psychiatric conditions.
4 CitationsSource
#2Alexey A. ShadrinH-Index: 11
Last. Anders M. DaleH-Index: 2
view all 12 authors...
Genome-Wide Association studies have typically been limited to single phenotypes, given that high dimensional phenotypes incur a large multiple comparisons burden: ~1 million tests across the genome times the number of phenotypes. Recent work demonstrates that a Multivariate Omnibus Statistic Test (MOSTest) is well powered to discover genomic effects distributed across multiple phenotypes. Applied to cortical brain MRI morphology measures, MOSTest has resulted in a drastic improvement in power t...
#1Meghana S Pagadala (UCSD: University of California, San Diego)H-Index: 3
#2Victoria WuH-Index: 8
Last. Hannah CarterH-Index: 30
view all 22 authors...
With the continued promise of immunotherapy as an avenue for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer risk screening and treatment strategies. Using genotypes from over 8,000 European individuals in The Cancer Genome Atlas (TCGA) and 137 heritable tumor immune phenotype components (IP components), we identified and investigated 482 TIME associations and 475 unique TIME-associated variants. Many TIME-...