Wesley K. Thompson
University of California, San Diego
Genome-wide association studyPsychiatryInternal medicineDevelopmental psychologySingle-nucleotide polymorphismPsychologyHeritabilityNeuroscienceCognitionGenetic associationBipolar disorderDiseaseComputer scienceGeneticsNeuroimagingClinical psychologyMedicineCohortBiologyGenetic architecture
Publications 291
#1Heekyeong Park (McGovern Institute for Brain Research)
#2Katherine L. Forthman (McGovern Institute for Brain Research)H-Index: 3
Last. Martin P. Paulus (McGovern Institute for Brain Research)H-Index: 107
view all 8 authors...
Abstract null null Background null Neuroticism is a heritable trait that contributes to the vulnerability to depression. We used polygenic risk scores (PRS) to examine genetic vulnerability to neuroticism and its associations with reward/punishment processing in a clinical sample with mood, anxiety, and substance use disorders. It was hypothesized that higher PRS for neuroticism is associated with attenuated neural responses to reward/punishment. null null null Method null Four hundred sixty-nin...
#1William E. Pelham (UCSD: University of California, San Diego)H-Index: 1
#2Susan F. Tapert (UCSD: University of California, San Diego)H-Index: 88
Last. Gayathri J. Dowling (NIDA: National Institute on Drug Abuse)H-Index: 10
view all 0 authors...
PURPOSE Evaluate changes in early adolescent substance use during the coronavirus disease 2019 (COVID-19) pandemic using a prospective, longitudinal, nationwide cohort. METHODS Participants were enrolled in the Adolescent Brain Cognitive Development Study. A total of 7,842 youth (mean age = 12.4 years, range = 10.5-14.6) at 21 study sites across the U.S. completed a three-wave assessment of substance use between May and August 2020. Youth reported whether they had used alcohol, nicotine, cannabi...
#1R. J. Loughnan (UCSD: University of California, San Diego)H-Index: 4
#2Jonathan Ahern (UCSD: University of California, San Diego)
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
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Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder that can lead to iron overload, causing oxidative damage to affected organs. HH type 1 is predominantly associated with homozygosity for the mutation p.C282Y. Previous case studies have reported tentative links between HH and movement disorders, e.g., Parkinson9s disease, and basal ganglia abnormalities on magnetic resonance imaging. We investigated the impact of p.C282Y homozygosity: on whole brain T2 intensity differenc...
#1Minh-Phuong Huynh-Le (UCSD: University of California, San Diego)H-Index: 10
#2Roshan Karunamuni (UCSD: University of California, San Diego)H-Index: 15
Last. Artitaya Lophatananon (University of Manchester)H-Index: 31
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Introduction: Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs in a prostate cancer polygenic hazard score (PHS) would improve associations with clinically significant prostate cancer in multi-ancestry datasets. Methods: In total, 299 SNPs previously associated with prostate canc...
#1Se Jin Song (UCSD: University of California, San Diego)H-Index: 34
#2Jincheng Wang (RU: Rutgers University)H-Index: 2
Last. Caroll Hernández (UC: Pontifical Catholic University of Chile)H-Index: 4
view all 27 authors...
Summary null null Background null Early microbiota perturbations are associated with disorders that involve immunological underpinnings. Cesarean section (CS)-born babies show altered microbiota development in relation to babies born vaginally. Here we present the first statistically powered longitudinal study to determine the effect of restoring exposure to maternal vaginal fluids after CS birth. null null null Methods null Using 16S rRNA gene sequencing, we followed the microbial trajectories ...
#1James Talwar (UCSD: University of California, San Diego)
#2David Laub (UCSD: University of California, San Diego)
Last. Kit Curtius (UCSD: University of California, San Diego)H-Index: 12
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Autoimmunity and cancer represent two different aspects of immune dysfunction. Autoimmunity is characterized by breakdowns in immune self-tolerance, while impaired immune surveillance can allow for tumorigenesis. The class I major histocompatibility complex (MHC-I), which displays derivatives of the cellular peptidome for immune surveillance by CD8+ T cells, serves as a common genetic link between these conditions. As melanoma-specific CD8+ T-cells have been shown to target melanocyte-specific p...
#1Nicole R. Karcher (WashU: Washington University in St. Louis)H-Index: 11
#2Sarah E. Paul (WashU: Washington University in St. Louis)H-Index: 3
Last. Ryan Bogdan (WashU: Washington University in St. Louis)H-Index: 37
view all 9 authors...
BACKGROUND Childhood psychotic-like experiences (PLEs) often precede the development of later severe psychopathology. The current study examined whether childhood PLEs are associated with several psychopathology-related polygenic scores (PGS), and additionally examined possible neural and behavioral mechanisms. METHODS Adolescent Brain Cognitive Development℠ Study baseline data from children with European ancestry (n=4,650; ages 9-10; 46.8% female) were used to estimate associations between PLEs...
1 CitationsSource
#1Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
#2R. J. Loughnan (UCSD: University of California, San Diego)H-Index: 4
Last. Ole A. Andreassen (Oslo University Hospital)H-Index: 123
view all 11 authors...
The molecular determinants of tissue composition of the human brain remain largely unknown. Recent genome-wide association studies (GWAS) on this topic have had limited success due to methodological constraints. Here, we apply advanced whole-brain analyses on multi-shell diffusion imaging data and multivariate GWAS to two large scale imaging genetic datasets (UK Biobank and the Adolescent Brain Cognitive Development study) to identify and validate genetic association signals. We discovered 503 u...
#1Sage Hahn (UVM: University of Vermont)H-Index: 2
#2Dekang Yuan (UVM: University of Vermont)H-Index: 2
Last. Hugh Garavan (UVM: University of Vermont)H-Index: 89
view all 6 authors...
Summary Brain Predictability toolbox (BPt) represents a unified framework of machine learning (ML) tools designed to work with both tabulated data (e.g., brain derived, psychiatric, behavioral, and physiological variables) and neuroimaging specific data (e.g., brain volumes and surfaces). This package is suitable for investigating a wide range of different neuroimaging-based ML questions, in particular, those queried from large human datasets. Availability and implementation BPt has been develop...
#1M Deanna (UW: University of Washington)H-Index: 106
#2Matthew D. Albaugh (UVM: University of Vermont)H-Index: 21
Last. Jay N. Giedd (UCSD: University of California, San Diego)H-Index: 124
view all 25 authors...
The Adolescent Brain Cognitive Development (ABCD) Study of 11,880 youth incorporates a comprehensive range of measures assessing predictors and outcomes related to mental health across childhood and adolescence in participating youth, as well as information about family mental health history. We have previously described the logic and content of the mental health assessment battery at Baseline and Year 1. Here, we describe changes to that battery and issues and clarifications that have emerged, ...