Yao Zhang
Pennsylvania State University
Self-healing hydrogelsBiophysicsCytoskeletonVirologyComposite materialTraction (engineering)MechanotransductionChemistryMaterials scienceSurface energyTraction force microscopyRed blood cellMalariaPlasmodium falciparumCelluloseStiffnessBallistic impactExtracellularTractive forceLipid bilayerMembraneProjectileSpectrinPolymerMechanicsBiofilmMolecular dynamicsStrain (chemistry)AdhesiveParasite hostingMulticellular organismAdhesionBiologyCell biologyPersistence length
20Publications
8H-index
338Citations
Publications 19
Newest
#1Yao Zhang (PSU: Pennsylvania State University)H-Index: 8
#2Jingyi Yu (PSU: Pennsylvania State University)
Last. Daniel J. Cosgrove (PSU: Pennsylvania State University)H-Index: 85
view all 6 authors...
Plants have evolved complex nanofibril-based cell walls to meet diverse biological and physical constraints. How strength and extensibility emerge from the nanoscale-to-mesoscale organization of growing cell walls has long been unresolved. We sought to clarify the mechanical roles of cellulose and matrix polysaccharides by developing a coarse-grained model based on polymer physics that recapitulates aspects of assembly and tensile mechanics of epidermal cell walls. Simple noncovalent binding int...
2 CitationsSource
Gap closure to eliminate physical discontinuities and restore tissue integrity is a fundamental process in normal development and repair of damaged tissues and organs. Here, we demonstrate a nonadhesive gap closure model in which collective cell migration, large-scale actin-network fusion, and purse-string contraction orchestrate to restore the gap. Proliferative pressure drives migrating cells to attach onto the gap front at which a pluricellular actin ring is already assembled. An actin-ring s...
Source
#1Elizabeth P. DeBenedictis (NU: Northwestern University)H-Index: 6
#2Yao Zhang (NU: Northwestern University)H-Index: 8
Last. Sinan Keten (NU: Northwestern University)H-Index: 34
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Fibrous networks of semiflexible polymers are prevalent in biological materials such as connective tissues, the cytoskeleton, and biofilm extracellular matrices. While the mechanical behavior of pe...
Source
#1Yao Zhang (PSU: Pennsylvania State University)H-Index: 8
#2Xuechen Shi (PSU: Pennsylvania State University)H-Index: 2
Last. Sulin Zhang (PSU: Pennsylvania State University)H-Index: 53
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Cancer metastasis has been believed as a genetically programmed process that is commonly marked by biochemical signals. Here using extracellular matrix control of cellular mechanics, we establish that cellular force threshold can also mark in vitro metastatic phenotypic change and malignant transformation in HCT-8 cell colonies. We observe that for prolonged culture time the HCT-8 cell colonies disperse into individual malignant cells, and the metastatic-like dispersion depends on both cell-seed...
4 CitationsSource
#1Yao Zhang (PSU: Pennsylvania State University)H-Index: 8
#2Qiong Wei (PSU: Pennsylvania State University)H-Index: 5
Last. Sulin Zhang (PSU: Pennsylvania State University)H-Index: 53
view all 5 authors...
Abstract Stress homeostasis in multicellular organisms is essential to tissue growth, development, and repair. However, how cellular forces are generated and transmitted within a multicellular organism to maintain stress homeostasis remains poorly understood. Here we employ cellular force microscopies to quantify extracellular traction and intercellular tension of circularly shaped cohesive epithelia seeded on hydrogels of various stiffness. Our experimental measurements show that the traction f...
3 CitationsSource
#1Yao Zhang (NU: Northwestern University)H-Index: 8
#2Elizabeth P. DeBenedictis (NU: Northwestern University)H-Index: 6
Last. Sinan Keten (NU: Northwestern University)H-Index: 34
view all 3 authors...
Biomolecular semiflexible polymer networks with persistence lengths well above those of single polymeric chains serve important structural and adhesive roles in biology, biomaterials, food science and many other fields. While relationships between the structure and viscoelasticity of semiflexible polymer networks have been previously investigated, it remains challenging to systematically relate fibril and network properties to cohesive and adhesive properties that govern the function of these ma...
6 CitationsSource
#1Wenjie Xia (NDSU: North Dakota State University)H-Index: 20
#2Xin Qin (NU: Northwestern University)H-Index: 7
Last. Sinan KetenH-Index: 34
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Understanding and designing nanoscale interfaces are essential to advancing the thermomechanical performance of polymer nanocomposites reinforced by nanocellulose. In this context, it remains to be understood how disorder introduced on the surfaces of crystals as filler materials during extraction and processing influences interfacial adhesion with glassy polymers. Using atomistic molecular dynamics (MD) simulations, here we systematically explore the interfacial adhesion between nanocellulose a...
27 CitationsSource
#1Qiong Wei (PSU: Pennsylvania State University)H-Index: 5
#2Changjin Huang (PSU: Pennsylvania State University)H-Index: 16
Last. Sulin Zhang (PSU: Pennsylvania State University)H-Index: 53
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: Targeted delivery of nanoparticle (NP)-based diagnostic and therapeutic agents to malignant cells and tissues has exclusively relied on chemotargeting, wherein NPs are surface-coated with ligands that specifically bind to overexpressed receptors on malignant cells. Here, it is demonstrated that cellular uptake of NPs can also be biased to malignant cells based on the differential mechanical states of cells, enabling mechanotargeting. Owing to mechanotransduction, cell lines (HeLa and HCT-8) cu...
20 CitationsSource
#1Tiankai Zhao (PSU: Pennsylvania State University)H-Index: 3
#2Yao Zhang (PSU: Pennsylvania State University)H-Index: 8
Last. Sulin Zhang (PSU: Pennsylvania State University)H-Index: 53
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Epithelial cells can assemble into cohesive monolayers with rich morphologies on substrates due to competition between elastic, edge, and interfacial effects. Here we present a molecularly based thermodynamic model, integrating monolayer and substrate elasticity, and force-mediated focal adhesion formation, to elucidate the active biochemical regulation over the cellular force landscapes in cohesive epithelial monolayers, corroborated by microscopy and immunofluorescence studies. The predicted e...
10 CitationsSource
#1Yao Zhang (NU: Northwestern University)H-Index: 8
#2Zhaoxu Meng (NU: Northwestern University)H-Index: 13
Last. Sinan Keten (NU: Northwestern University)H-Index: 34
view all 4 authors...
Therapeutic agent loaded micro and nanoscale particles as high-velocity projectiles can penetrate cells and tissues, thereby serving as gene and drug delivery vehicles for direct and rapid internalization. Despite recent progress in developing micro/nanoscale ballistic tools, the underlying biophysics of how fast projectiles deform and penetrate cell membranes is still poorly understood. To understand the rate and size-dependent penetration processes, we present coarse-grained molecular dynamics...
5 CitationsSource