Gianfranco Pintus
University of Sassari
Endothelial stem cellInternal medicineEndocrinologyMolecular biologyChemistryProtein kinase COxidative stressAntioxidantVascular smooth muscleMitochondrionCapillary electrophoresisProgrammed cell deathChromatographyReactive oxygen speciesCancer researchBiochemistrySignal transductionMedicineBiologyCell biologyPharmacology
137Publications
32H-index
3,178Citations
Publications 137
Newest
#1Marina Bacci (UniFI: University of Florence)H-Index: 5
#2Elisa Giannoni (UniFI: University of Florence)H-Index: 52
Last. Andrea Morandi (UniFI: University of Florence)H-Index: 23
view all 12 authors...
Aromatase inhibitors (AI) have become the first-line endocrine treatment of choice for postmenopausal estrogen receptor–positive (ER+) breast cancer patients, but resistance remains a major challenge. Metabolic reprogramming is a hallmark of cancer and may contribute to drug resistance. Here, we investigated the link between altered breast cancer metabolism and AI resistance using AI-resistant and sensitive breast cancer cells, patient tumor samples, and AI-sensitive human xenografts. We found t...
48 CitationsSource
#1Federica Rizzi (University of Parma)H-Index: 26
#2Ioannis P. Trougakos (UoA: National and Kapodistrian University of Athens)H-Index: 36
Last. Gerasimos P. SykiotisH-Index: 31
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An extensive network of components, generally referred to as the proteostasis network (PN), safeguards the functionality and integrity of the proteome, thus ensuring an optimal and efficient cell function. Failure of the PN represents a common trait of several chronic and age-related pathological conditions. This special issue features a collection of reviews and original articles covering distinct aspects of the effect of redox imbalance on the integrated complex of adaptive molecular signaling...
1 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Alessandro G. Fois (University of Sassari)H-Index: 17
Last. Pietro Pirina (University of Sassari)H-Index: 26
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Chronic obstructive pulmonary disease (COPD) and asthma are both characterized by heterogeneous chronic airway inflammation and obstruction as well as oxidative stress (OS). However, it is unknown whether OS occurs in early disease and how to best assess its presence. Plasma OS markers (TBARS, PSH, taurine, GSH, ergothioneine and paraoxonase 1 activity) and lung function tests were measured in patients with mild stable asthma (n = 24) and mild stable COPD (n = 29) and in age- and sex-matched con...
31 CitationsSource
#1Salvatore Sotgia (University of Sassari)H-Index: 25
#2Angelo Zinellu (University of Sassari)H-Index: 31
Last. Sergio Ledda (University of Sassari)H-Index: 27
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Abstract l -ergothioneine levels were measured in amniotic fluid of pregnant sheep after natural mating and transfer of vitrified/thawed in-vitro produced embryos. Amniotic fluids were collected between 60 and 65 and 80–85 days of gestation and analysed by an ultra-performance liquid chromatographic (UPLC) method with fluorescence detection. l -Ergothioneine concentrations ranged between 0.23 and 9.36 μmol/L and were significantly higher in pregnancy obtained by the transfer of vitrified/thawed ...
6 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Salvatore Sotgia (University of Sassari)H-Index: 25
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
view all 9 authors...
Epicatechin (EC), epigallocatechin (EGC), epicatechingallate (ECG) and epigallocatechingallate (EGCG) are antioxidants present in the green tea, a widely used beverage whose health benefits are largely recognized. Nevertheless, major physicochemical limitations, such as the high instability of catechins, pose important questions concerning their potential pharmacological use. Recent studies indicate that binding of catechins with plasmatic proteins may modulate their plasma concentration, tissue...
17 CitationsSource
#1Andrea ManuntaH-Index: 8
#2Pietro ZeddeH-Index: 4
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
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in pathological conditions such as osteo-arthritis (OA), overproduction of reactive oxygen species (ROS) may overwhelm the antioxidant defenses of chondrocytes, thus promoting oxidative stress and cell death. It can be hypothesized that increasing the antioxidant machinery of chondrocytes may prevent the age-associated progression of this disease. Growth factors (GFs) play an important role in promoting both the resolution of inflammatory processes and tissue repair. In view of these considerati...
3 CitationsSource
#1Anna Maria Posadino (University of Sassari)H-Index: 19
#2A Cossu (University of Sassari)H-Index: 14
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
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Abstract Studies analyzing the impact of natural antioxidants (NA) on Endothelial Cells (ECs) have dramatically increased during the last years, since a deregulated ECs redox state is at the base of the onset and progression of several cardiovascular diseases. However, whether NA can provide cardiovascular benefits is still a controversial area of debate. Resveratrol (RES), a natural polyphenol found in grapes, is believed to provide cardiovascular benefits by virtue of its antioxidant effect on...
36 CitationsSource
#1Salvatore Sotgia (University of Sassari)H-Index: 25
#2Angelo Zinellu (University of Sassari)H-Index: 31
Last. Luisa Bogliolo (University of Sassari)H-Index: 24
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The aim of this study was to evaluate the concentration of l-ergothioneine in follicular fluid of some domestic farm animals, such as mare, sheep, goat, sow, and unweaned lamb. The group of unweaned lambs was the cluster with the lowest mean concentration (0.12 ± 0.06 μmol/L), while the mares showed the highest mean values (3.16 ± 1.27 μmol/L). The mean levels in the sheep and goats were similar (0.72 ± 0.21 vs. 0.73 ± 0.50 μmol/L), while the mean values in the sows were slightly higher (1.04 ± ...
2 CitationsSource
#1Ilaria Floris (UoB: University of Bristol)H-Index: 9
#2Betty Descamps (UoB: University of Bristol)H-Index: 6
Last. Costanza EmanueliH-Index: 75
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Objective— Gestational diabetes mellitus (GDM) produces fetal hyperglycemia with increased lifelong risks for the exposed offspring of cardiovascular and other diseases. Epigenetic mechanisms induce long-term gene expression changes in response to in utero environmental perturbations. Moreover, microRNAs (miRs) control the function of endothelial cells (ECs) under physiological and pathological conditions and can target the epigenetic machinery. We investigated the functional and expressional ef...
64 CitationsSource
#1Anna Maria PosadinoH-Index: 19
#2A CossuH-Index: 14
Last. Gianfranco PintusH-Index: 32
view all 10 authors...