Gianfranco Pintus
University of Sassari
Endothelial stem cellInternal medicineEndocrinologyMolecular biologyChemistryProtein kinase COxidative stressAntioxidantVascular smooth muscleMitochondrionCapillary electrophoresisProgrammed cell deathChromatographyReactive oxygen speciesCancer researchBiochemistrySignal transductionMedicineBiologyCell biologyPharmacology
137Publications
32H-index
3,178Citations
Publications 137
Newest
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Panagiotis Paliogiannis (University of Sassari)H-Index: 19
Last. Alessandro G. Fois (University of Sassari)H-Index: 17
view all 14 authors...
PURPOSE Inflammation and immunity play a pivotal but yet unclear role in idiopathic pulmonary fibrosis (IPF), a chronic disorder characterized by progressive damage of lung parenchyma and severe loss of lung function despite optimal treatment. However, the pathophysiological and predictive role of combined blood cell count indexes of inflammation in IPF is uncertain. METHODS Seventy-three patients with IPF and 62 healthy subjects matched for age, gender and smoking status were included in this c...
3 CitationsSource
Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Since late 2019, COVID-19 has rapidly spread in virtually all countries, imposing the adoption of significant lockdown and social distancing measures The activation of the coagulation cascade is a common feature of disseminated intravascular coagulation and adverse clinical outcomes in COVID-19 patients In this study, we conducted a meta-analysis a...
13 CitationsSource
#1Humna Bhagani (AUB: American University of Beirut)H-Index: 2
#2Suzanne A. Nasser (Beirut Arab University)H-Index: 5
Last. Ali H. Eid (AUB: American University of Beirut)H-Index: 26
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Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; however, several processes involving the mitochondria, such as lipid and glucose metabolism, reactive oxygen species (ROS) production, apoptosis, autophagy and mitochondrial biogenesis have been implicated. In addition, polyphenols have been shown to improve the progression of di...
4 CitationsSource
#1Hoa T PhuH-Index: 1
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
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: Aging and aging-associated diseases are issues with unsatisfactory answers in the medical field. Aging causes important physical changes which, even in the absence of the usual risk factors, render the cardiovascular system prone to some diseases. Although aging cannot be prevented, slowing down the rate of aging is entirely possible to achieve. In some traditional medicine, medicinal herbs such as Ginseng, Radix Astragali, Ganoderma lucidum, Ginkgo Biloba, and Gynostemma pentaphyllum are recog...
10 CitationsSource
#1Roberta Giordo (Qatar University)H-Index: 13
#2Gheyath K. Nasrallah (Qatar University)H-Index: 27
Last. Gianfranco Pintus (College of Health Sciences, Bahrain)H-Index: 32
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Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. Oxidative stress is recognized as the primary trigger of NP-associated toxicity, suggesting antioxidants as a promising counteractive approach. Here, we investigated the protective effect of the natural antioxidant resveratrol against ZnO NP-induced toxicity in vivo using the zebrafi...
7 CitationsSource
#1Abdullah Shaito (Lebanese International University)H-Index: 9
Last. Gianfranco Pintus (UOS: University of Sharjah)H-Index: 32
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Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an alternative treatment approach for several diseases including CVDs. Currently, there is an unprecedented drive for the use of herbal preparations in modern medicinal systems. This drive is powered by several aspects, prime among which are their cost-effective therapeutic promise compar...
21 CitationsSource
#1Abdullah Shaito (Lebanese International University)H-Index: 9
#2Anna Maria Posadino (University of Sassari)H-Index: 19
Last. Gianfranco Pintus (College of Health Sciences, Bahrain)H-Index: 32
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Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available h...
49 CitationsSource
Marine biofouling is considered to be one of the most challenging issues affecting maritime industries worldwide. In this regard, traditional biocides, being used to combat biofouling, have high toxicity toward aquatic systems. Recently, a new chitosan/zinc oxide nanoparticle (CZNC) composite has been used as a promising “green” biocide. It is thought that because of the ecofriendly nature of chitosan, CZNCs may pave the way to developing less toxic surfaces for combating marine fouling. Zebrafi...
4 CitationsSource
#1Nadin Younes (College of Health Sciences, Bahrain)H-Index: 10
#2Salma Younes (College of Health Sciences, Bahrain)H-Index: 6
Last. Hatem Zayed (College of Health Sciences, Bahrain)H-Index: 20
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: Celiac Disease (CD) is a complex immunogenic disease mainly triggered by gluten intake in genetically susceptible individuals with a prevalence of 1 in 100-300. CD results from the interplay between genetic and environmental factors. Genetic susceptibility is believed to play a prominent role in the pathogenicity of CD, mainly due to human leukocyte antigen (HLA)-related class II genes. Although CD is well-recognized among Arab populations, there are few studies on the genetic epidemiology and...
1 CitationsSource
#1Nadine Wehbe (AUB: American University of Beirut)H-Index: 3
#2Suzanne Awani Nasser (Beirut Arab University)H-Index: 1
Last. Elias Baydoun (AUB: American University of Beirut)H-Index: 21
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Like other organs, the heart undergoes normal adaptive remodeling, such as cardiac hypertrophy, with age. This remodeling, however, is intensified under stress and pathological conditions. Cardiac remodeling could be beneficial for a short period of time, to maintain a normal cardiac output in times of need; however, chronic cardiac hypertrophy may lead to heart failure and death. MicroRNAs (miRNAs) are known to have a role in the regulation of cardiac hypertrophy. This paper reviews recent adva...
10 CitationsSource