Gianfranco Pintus
University of Sassari
Endothelial stem cellInternal medicineEndocrinologyMolecular biologyChemistryProtein kinase COxidative stressAntioxidantVascular smooth muscleMitochondrionCapillary electrophoresisProgrammed cell deathChromatographyReactive oxygen speciesCancer researchBiochemistrySignal transductionMedicineBiologyCell biologyPharmacology
Publications 138
#1Halima Alsamri (United Arab Emirates University)H-Index: 3
#2Khawlah Athamneh (United Arab Emirates University)H-Index: 6
Last. Rabah Iratni (United Arab Emirates University)H-Index: 21
view all 5 authors...
Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in traditional medicine for the management and treatment of many ailments including hemorrhoids, wound healing, diarrhea, ulcer, and eye inflammation. This plant is rich in various classes of phytochemicals including flavonoids, tannins, polyphenolic compounds, organic acids, and ...
4 CitationsSource
#1Arduino A. Mangoni (Flinders Medical Centre)H-Index: 40
#2Sara Tommasi (Flinders Medical Centre)H-Index: 7
Last. Gian Luca Erre (University of Sassari)H-Index: 17
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Patients with rheumatoid arthritis (RA), a chronic and disabling autoimmune condition that is characterized by articular and extra-articular manifestations and a pro-inflammatory and pro-oxidant state, suffer from premature atherosclerosis and excessive cardiovascular disease burden. A key step in the pathogenesis of atherosclerosis is the impaired synthesis of the endogenous messenger nitric oxide (NO) by endothelial cells which, in turn, alters local homeostatic mechanisms and favors vascular ...
1 CitationsSource
#1Panagiotis Paliogiannis (University of Sassari)H-Index: 19
#2Sara S Fois (University of Sassari)H-Index: 3
Last. Gianfranco Pintus (College of Health Sciences, Bahrain)H-Index: 32
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Idiopathic pulmonary fibrosis (IPF) is an aggressive pulmonary disease which shares several molecular, patho-physiological and clinical aspects with lung cancer, including high mortality rates. The antifibrotic drugs Nintedanib and Pirfenidone have been recently introduced in clinical practice for the treatment of IPF. Nintedanib is also used for the treatment of several malignancies, including non-small cell lung cancer (NSCLC) in combination with Docetaxel, while Pirfenidone showed some anti-n...
1 CitationsSource
#1Paola DettoriH-Index: 1
#2Panagiotis Paliogiannis (University of Sassari)H-Index: 19
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
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Carotid artery disease is commonly encountered in clinical practice and accounts for approximately 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated as predictors of the onset and progression of carotid disease, the occurrence of cerebrovascular complications, and overall prognosis. Among them, blood cell count (BCC) indexes of systemic inflammation might be particularly useful, from a pathophysiological and clinical point of view, given the inflammato...
2 CitationsSource
#1Maha Al-Asmakh (Qatar University)H-Index: 11
#2Amin F. Majdalawieh (AUS: American University of Sharjah)H-Index: 21
Last. Gheyath K. Nasrallah (Qatar University)H-Index: 27
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Fatty alcohol polyoxyethylene ether-7 (AEO-7), a non-ionic surfactant, has recently been receiving extensive attention from the ocean pipeline industry for its ability to inhibit corrosion. However, the present lack of information concerning the potential environmental toxicity of AEO-7, especially towards aquatic organisms, is a major impediment to its wider application. Here, we assess potential adverse effects of AEO-7 on zebrafish embryos employing a variety of assays, including (i) a mortal...
1 CitationsSource
#1Ali Dakroub (AUB: American University of Beirut)H-Index: 2
#2Suzanne A. Nasser (Beirut Arab University)H-Index: 5
Last. Ali H. Eid (AUB: American University of Beirut)H-Index: 26
view all 9 authors...
Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions in nicotinamide adenine dinucleotide biosynthesis, with ubiquitous expression in skeletal muscles, liver, cardiomyocytes, and brain cells. Visfatin exists in an intracellular (iNAMPT) and extracellular (eNAMPT) form. Intracellularly, visfatin/iNAMPT plays a regulatory role in NAD...
5 CitationsSource
#1Ola Al-Jamal (Qatar University)H-Index: 4
#2Hadeel Al-Jighefee (Qatar University)H-Index: 4
Last. Gheyath K. Nasrallah (Qatar University)H-Index: 27
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Abstract Surfactants are widely used in the industry of detergents, household products, and cosmetics. SAPDMA is a cationic surfactant that is used mostly in cosmetics, conditioning agents and has recently gained attention as a corrosion inhibitor in the sea pipelines industry. In this regard, literature concerning the ecotoxicological classification of SAPDMA on aquatic animals is lacking. This study aims to evaluate the potential ecotoxicity of SAPDMA using the aquatic zebrafish embryo model. ...
2 CitationsSource
#1Alessandro G. Fois (University of Sassari)H-Index: 17
#2Elisabetta Sotgiu (University of Sassari)H-Index: 9
Last. Angelo Zinellu (University of Sassari)H-Index: 31
view all 11 authors...
Introduction: In vitro evidence suggests that pirfenidone and nintedanib, approved agents for the treatment of idiopathic pulmonary fibrosis (IPF), exert anti-inflammatory and anti-oxidant effects. We aimed to investigate such effects in vivo in IPF patients. Methods: Systemic circulating markers of oxidative stress [nuclear factor erythroid 2–related factor 2 (Nrf2), thiobarbituric acid- reactive substances (TBARS), homocysteine (Hcy), cysteine (Cys), asymmetric dimethylarginine (ADMA) and ADMA...
#1Panagiotis Paliogiannis (University of Sassari)H-Index: 19
#2Antonella Maria Fara (University of Sassari)H-Index: 1
Last. Antonio Cossu (University of Sassari)H-Index: 32
view all 8 authors...
Background and Objectives: The respiratory apparatus, generally affected by highly aggressive tumors like lung cancer and mesothelioma, is rarely affected by primary malignant melanoma. The aim of this review was to identify cases of primary malignant melanoma of the lung (PMML) published in the modern scientific literature, and to describe their main clinical, pathological and therapeutic features. Materials and Methods: A systematic search of publications in the electronic database PubMed has ...
1 CitationsSource
#1Helene Ismail (AUB: American University of Beirut)H-Index: 1
#2Zaynab Shakkour (AUB: American University of Beirut)H-Index: 3
Last. Johnny Salameh (AUB: American University of Beirut)H-Index: 13
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Traumatic brain injury (TBI) is a major health concern worldwide and is classified based on severity into mild, moderate, and severe. The mechanical injury in TBI leads to a metabolic and ionic imbalance, which eventually leads to excessive production of reactive oxygen species (ROS) and a state of oxidative stress. To date, no drug has been approved by the food and drug administration (FDA) for the treatment of TBI. Nevertheless, it is thought that targeting the pathology mechanisms would allev...
5 CitationsSource