Gianfranco Pintus
University of Sassari
Endothelial stem cellInternal medicineEndocrinologyMolecular biologyChemistryProtein kinase COxidative stressAntioxidantVascular smooth muscleMitochondrionCapillary electrophoresisProgrammed cell deathChromatographyReactive oxygen speciesCancer researchBiochemistrySignal transductionMedicineBiologyCell biologyPharmacology
Publications 138
#1Valeria PasciuH-Index: 14
#2Anna Maria PosadinoH-Index: 19
Last. Gianfranco PintusH-Index: 32
view all 10 authors...
High intake of natural antioxidants (NA) from plant-derived foods and beverages is thought to provide cardiovascular benefits. The endothelium plays a pivotal role in cardiovascular homeostasis, and for this reason, the molecular events resulting from NA actions on endothelial cells (ECs) are actively investigated. Here, we show the direct impact of two NA, coumaric acid and resveratrol, on intracellular reactive oxygen species levels, protein carbonylation, and cell physiology in human ECs. Whi...
48 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Salvatore Sotgia (University of Sassari)H-Index: 25
Last. Ciriaco Carru (University of Sassari)H-Index: 38
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Abstract Objective In recent years elevated homocysteine (Hcy) levels have been widely recognized as a risk factor for cardiovascular diseases (CVDs) and a connection between hyperhomocysteinemia and lipid metabolism has been suggested to have a possible role in endothelial vascular damage as lipoprotein fractions contain higher Hcy levels in hypercholesterolemia, compared to normolipidemic individuals. However, the biochemical events underlying the interaction between Hcy and LDL are still poor...
32 CitationsSource
#1Zongming Fu (NIH: National Institutes of Health)H-Index: 13
#1Zongming Fu (NIH: National Institutes of Health)H-Index: 1
Last. Jennifer E. Van Eyk (Johns Hopkins University)H-Index: 84
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Advancing age induces aortic wall thickening that results from the concerted effects of numerous signaling proteins, many of which have yet to be identified. To search for novel proteins associated with aortic wall thickening, we have performed a comprehensive quantitative proteomic study to analyze aortic proteins from young (8 months) and old (30 months) rats and identified 50 proteins that significantly change in abundance with aging. One novel protein, the milk fat globule protein epidermal ...
76 CitationsSource
#1Federica RizziH-Index: 26
Last. Saverio BettuzziH-Index: 24
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#1Ciriaco CarruH-Index: 38
#2Angelo ZinelluH-Index: 31
Last. Luca DeianaH-Index: 32
view all 11 authors...
#1Anna Maria PosadinoH-Index: 19
#2A CossuH-Index: 14
Last. Gianfranco PintusH-Index: 32
view all 12 authors...
The health-promoting effects of fruit and vegetable consumption are thought to be due to phytochemicals contained in fresh plant material. Whether processed plant foods provide the same benefits as unprocessed ones is an open question. Melanoidins from heat-processed plums (prunes) were isolated and their presence confirmed by hydroxymethylfurfural content and browning index. Oxidative-induced endothelial cell (EC) damage is the trigger for the development of cardiovascular diseases (CVD); there...
10 CitationsSource
#1Liqun Jiang (NIH: National Institutes of Health)H-Index: 10
#2Mingyi Wang (NIH: National Institutes of Health)H-Index: 28
Last. Edward G. Lakatta (NIH: National Institutes of Health)H-Index: 18
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Background: Angiotensin II (Ang II) signaling, including matrix metalloproteinase type II (MMP2) activation, has been linked to an age-associated increase in migration capacity of vascular smooth muscle cells (VSMC), and to other proinflammatory features of arterial aging. Calpain-1 activation is required for MMP2 expression in fibroblasts and is induced in cardiomyocytes by Ang II. The consequences of engagement of calpain-1 with its substrates, however, in governing the age-associated proinfla...
80 CitationsSource
Reactive oxygen species (ROS) cause cell damages through protein oxidation leading to pathological processes like cardiovascular disease neurological degeneration and cancer (1). Antioxidants molecules, due to their ability to scavenge and neutralize free radicals, might play a pivotal role in the prevention of these disease. Interestingly, besides neutralizing ROS, it’s now proved that some promising antioxidant molecules, including green tea polyphenols (2), induce the expression of genes invo...