Gianfranco Pintus
University of Sassari
Endothelial stem cellInternal medicineEndocrinologyMolecular biologyChemistryProtein kinase COxidative stressAntioxidantVascular smooth muscleMitochondrionCapillary electrophoresisProgrammed cell deathChromatographyReactive oxygen speciesCancer researchBiochemistrySignal transductionMedicineBiologyCell biologyPharmacology
137Publications
32H-index
3,178Citations
Publications 137
Newest
#1Vanna SannaH-Index: 29
#2Gianfranco PintusH-Index: 32
Last. Mario SechiH-Index: 33
view all 9 authors...
Ultrasound-targeted microbubbles (MBs) offer new opportunities to enhance the capabilities of diagnostic ultrasound (US) imaging to specific pathological tissue. Herein, we report on the design and development of a novel prototype of US contrast agent based on polymeric MBs targeted to prostate-specific membrane antigen (PSMA) for use in the diagnosis of prostate cancer (PCa). First, a set of air-filled MBs by a variety of biocompatible polymers were prepared and characterized in terms of morpho...
55 CitationsSource
#1Ciriaco CarruH-Index: 38
#2Valeria PasciuH-Index: 14
Last. Gianfranco PintusH-Index: 32
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Antioxidants exert contrasting effect on low density lipoprotein (LDL) oxidation catalysed by metals, acting as pro-oxidants under select in vitro conditions. Through our study on the effect of coffee on LDL oxidation, we identified the parameters governing this phenomenon, contributing to the comprehension of its mechanism and discovering significant implications for correct alimentary recommendations. By measuring conjugated diene formation, we have analysed the quantitative and qualitative ef...
9 CitationsSource
#1Vanna SannaH-Index: 29
#2Anna Maria RoggioH-Index: 11
Last. Mario Sechi (University of Sassari)H-Index: 33
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Docetaxel (Dtx) chemotherapy is the optional treatment in patients with hormone-refractory metastatic prostate cancer, and Dtx-loaded polymeric nanoparticles (NPs) have the potential to induce durable clinical responses. However, alternative formulations are needed to overcome the serious side effects, also due to the adjuvant used, and to improve the clinical efficacy of the drug. In the present study, two novel biodegradable block-copolymers, poly(lactide-co-caprolactone) (PLA-PCL) and poly (l...
90 CitationsSource
#1Vanna SannaH-Index: 29
#2Gianfranco PintusH-Index: 32
Last. Mario SechiH-Index: 33
view all 10 authors...
Molecular targeted cancer therapy mediated by nanoparticles (NPs) is a promising strategy to overcome the lack of specificity of conventional chemotherapeutic agents. In this context, the prostate-specific membrane antigen (PSMA) has demonstrated a powerful potential for the management of prostate cancer (PCa). Cancer chemoprevention by phytochemicals is emerging as a suitable approach for the treatment of early carcinogenic processes. Since (−)-epigallocatechin 3-gallate (EGCG) has shown potent...
98 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Salvatore Sotgia (University of Sassari)H-Index: 25
Last. Ciriaco Carru (University of Sassari)H-Index: 38
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Here, we describe an easy field-amplified sample injection capillary electrophoresis method with UV detection for the separation and detection of free plasma arginine and dimethylated arginines. The analytes were baseline-separated within 22 min by using 50 mmol/L Tris phosphate pH 2.3 as running buffer. The plasma samples were treated with acetonitrile/ammonia for protein elimination, the supernatants were dried, re-swollen in water and directly injected in the capillary without complex cleanup...
28 CitationsSource
#1A CossuH-Index: 14
#2Anna Maria PosadinoH-Index: 19
Last. Gianfranco PintusH-Index: 32
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Last. Sergio UzzauH-Index: 46
view all 8 authors...
#1Stefania PunzoniH-Index: 2
#2Vanna SannaH-Index: 29
Last. Gianfranco PintusH-Index: 32
view all 9 authors...
1 CitationsSource
#1Giuseppe VirgilioH-Index: 6
Last. MigaledduH-Index: 1
view all 9 authors...
#1Valeria PasciuH-Index: 14
#2Anna Maria PosadinoH-Index: 19
Last. Gianfranco PintusH-Index: 32
view all 10 authors...
High intake of natural antioxidants (NA) from plant-derived foods and beverages is thought to provide cardiovascular benefits. The endothelium plays a pivotal role in cardiovascular homeostasis, and for this reason, the molecular events resulting from NA actions on endothelial cells (ECs) are actively investigated. Here, we show the direct impact of two NA, coumaric acid and resveratrol, on intracellular reactive oxygen species levels, protein carbonylation, and cell physiology in human ECs. Whi...
40 CitationsSource