Gianfranco Pintus
University of Sassari
Endothelial stem cellInternal medicineEndocrinologyMolecular biologyChemistryProtein kinase COxidative stressAntioxidantVascular smooth muscleMitochondrionCapillary electrophoresisProgrammed cell deathChromatographyReactive oxygen speciesCancer researchBiochemistrySignal transductionMedicineBiologyCell biologyPharmacology
137Publications
32H-index
3,178Citations
Publications 137
Newest
#1Maria Carmina Pau (University of Sassari)H-Index: 3
#2Elisabetta ZinelluH-Index: 16
Last. Pietro Pirina (University of Sassari)H-Index: 26
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Oxidative stress induced by nocturnal intermittent hypoxia plays a significant pathophysiological role in obstructive sleep apnea (OSA). Malondialdehyde (MDA), one of the most commonly investigated markers of lipid peroxidation, might assist with the monitoring of oxidative balance in OSA. We conducted a systematic review and meta-analysis to evaluate the differences in circulating MDA concentrations between patients with OSA and non-OSA controls. A systematic search was conducted in the electro...
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#1Roberta Giordo (College of Health Sciences, Bahrain)H-Index: 13
#2Yusra M. A. Ahmed (College of Health Sciences, Bahrain)
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
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Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ dysfunction, disability, and increased mortality. A common denominator of these complications is the myofibroblast-driven excessive deposition of extracellular matrix proteins. Although fibroblast appears to be the primary source of myofibroblasts, other cells, including endothelial cells, can generate myofibroblasts throu...
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#1Anna Maria PosadinoH-Index: 19
#2A CossuH-Index: 14
Last. Gianfranco PintusH-Index: 32
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This work aims to analyze the chemical and biological evaluation of two extracts obtained by olive mill wastewater (OMW), an olive oil processing byproduct. The exploitation of OMW is becoming an important aspect of development of the sustainable olive oil industry. Here we chemically and biologically evaluated one liquid (L) and one solid (S) extract obtained by liquid-liquid extraction followed by acidic hydrolysis (LLAC). Chemical characterization of the two extracts indicated that S has high...
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#1Zena WehbeH-Index: 4
#2Maya WehbeH-Index: 1
Last. Ali H. EidH-Index: 26
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As of January 2021, SARS-CoV-2 has killed over 2 million individuals across the world. As such, there is an urgent need for vaccines and therapeutics to reduce the burden of COVID-19. Several vaccines, including mRNA, vector-based vaccines, and inactivated vaccines, have been approved for emergency use in various countries. However, the slow roll-out of vaccines and insufficient global supply remains a challenge to turn the tide of the pandemic. Moreover, vaccines are important tools for prevent...
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#1Lara J. Bou Malhab (UOS: University of Sharjah)H-Index: 1
#2Maha Saber-Ayad (UOS: University of Sharjah)H-Index: 8
Last. Wael M. Abdel-Rahman (UOS: University of Sharjah)H-Index: 25
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Long-lasting subclinical inflammation is associated with a wide range of human diseases, particularly at middle and older age. Recent reports showed that there is a direct causal link between inflammation and cancer development, as several cancers were found to be associated with chronic inflammatory conditions. In patients with cancer, healthy endothelial cells regulate vascular homeostasis, and it is believed that they can limit tumor growth, invasiveness, and metastasis. Conversely, dysfuncti...
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#2Panagiotis Paliogiannis (University of Sassari)H-Index: 19
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
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Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an abnormal fibrotic response involving vast areas of the lungs. Given the poor knowledge of the mechanisms underpinning IPF onset and progression, a better understanding of the cellular processes and molecular pathways involved is essential for the development of effective therapies, currently lacking. Besides a number of e...
1 CitationsSource
#1Roberta Giordo (College of Health Sciences, Bahrain)H-Index: 13
#2Panagiotis Paliogiannis (University of Sassari)H-Index: 19
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
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SARS-CoV-2 is the agent responsible for the coronavirus disease (COVID-19), which has been declared a pandemic by the World Health Organization. The clinical evolution of COVID-19 ranges from asymptomatic infection to death. Older people and patients with underlying medical conditions, particularly diabetes, cardiovascular and chronic respiratory diseases are more susceptible to develop severe forms of COVID-19. Significant endothelial damage has been reported in COVID-19 and growing evidence su...
2 CitationsSource
#1Roberta Giordo (College of Health Sciences, Bahrain)H-Index: 13
#2Angelo Zinellu (University of Sassari)H-Index: 31
Last. Gianfranco Pintus (College of Health Sciences, Bahrain)H-Index: 32
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Coagulation disorders, endotheliopathy and inflammation are the most common hallmarks in SARS-CoV-2 infection, largely determining COVID-19’s outcome and severity. Dysfunctions of endothelial cells and platelets are tightly linked in contributing to the systemic inflammatory response that appears to be both a cause and a consequence of COVID-19-associated coagulation disorders and thrombotic events. Indeed, elevated levels of circulating inflammatory cytokines are often associated with abnormal ...
1 CitationsSource
#1Roberta Giordo (College of Health Sciences, Bahrain)H-Index: 13
#2Gheyath K. Nasrallah (College of Health Sciences, Bahrain)H-Index: 27
Last. Gianfranco Pintus (College of Health Sciences, Bahrain)H-Index: 32
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Diabetes-associated long-term hyperglycaemia leads to oxidative stress-mediated fibrosis in different tissues and organs. Endothelial-to-mesenchymal-transition (EndMT) appears to play a role in diabetes-associated fibrotic conditions. Here, we investigate whether EndMT is implicated in the diabetic retinopathy fibrotic process and evaluate the possibility that resveratrol could counteract EndMT by inhibiting high glucose (HG)-induced increases in ROS. Primary Human Retinal Endothelial Cells (HRE...
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#1Halima Alsamri (United Arab Emirates University)H-Index: 3
#2Khawlah Athamneh (United Arab Emirates University)H-Index: 6
Last. Rabah Iratni (United Arab Emirates University)H-Index: 21
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Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in traditional medicine for the management and treatment of many ailments including hemorrhoids, wound healing, diarrhea, ulcer, and eye inflammation. This plant is rich in various classes of phytochemicals including flavonoids, tannins, polyphenolic compounds, organic acids, and ...
2 CitationsSource