Soon Koo Baik
Yonsei University
Internal medicineRadiologyEndocrinologySurgeryPathologyCardiologyProspective cohort studyMesenchymal stem cellLiver diseaseCirrhosisAlcoholic liver diseaseHepatocellular carcinomaPortal hypertensionFibrosisHepatic fibrosisIn patientCancer researchPortal venous pressureMedicineGastroenterology
238Publications
42H-index
4,332Citations
Publications 237
Newest
#1Jaesik Shin (Yonsei University)
#2Soon Koo Baik (Yonsei University)H-Index: 42
Last. Young Woo Eom (Yonsei University)H-Index: 17
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BACKGROUND/AIM Genetic manipulation of stem cells using non-viral vectors is still limited due to low transfection efficiency. We investigated whether the DNA-binding cell-permeation peptides (CPP) can enhance the transfection efficiency of non-viral vectors in adipose tissue-derived mesenchymal stem cells (ASCs) and whether ASCs over-expressing TRAIL through CPP can inhibit the growth of glioma U251MG cells in vitro and in vivo. MATERIALS AND METHODS ASCs were genetically engineered to over-exp...
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#1Hye Yeon Chon (Yonsei University)H-Index: 1
#2Yeon Seok Seo (KU: Korea University)H-Index: 28
Last. Seung Up Kim (Yonsei University)H-Index: 55
view all 42 authors...
OBJECTIVE The liver stiffness-based risk prediction models predict hepatocellular carcinoma (HCC) development. We investigated the influence of antiviral therapy (AVT) on liver stiffness-based risk prediction model in patients with chronic hepatitis B (CHB). METHODS Patients with CHB who initiated AVT were retrospectively recruited from 13 referral Korean institutes. The modified risk estimation for hepatocellular carcinoma in chronic hepatitis B (mREACH-B) model was selected for the analysis. R...
1 CitationsSource
PURPOSE OF REVIEW Liver transplantation is the gold standard for the treatment of end-stage liver disease. However, a shortage of donor organs, high cost, and surgical complications limit the use of this treatment. Cellular therapies using hepatocytes, hematopoietic stem cells, bone marrow mononuclear cells, and mesenchymal stem cells (MSCs) are being investigated as alternative treatments to liver transplantation. The purpose of this review is to describe studies using MSC transplantation for l...
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#1Seong Hee Kang (Yonsei University)H-Index: 10
#2Minjong Lee (Ewha Womans University)H-Index: 19
Last. Soon Koo Baik (Yonsei University)H-Index: 42
view all 12 authors...
BACKGROUND/AIM We investigated the effect of non-selective β-blockers (NSBB) in real-world situations and whether low-dose NSBB is beneficial compared to maximally tolerated doses. METHODS We performed a retrospective study of 740 patients with cirrhosis requiring prophylactic treatment of esophageal varices: 473 primary prophylaxis (PP: NSBB = 349, non-NSBB = 124) and 267 secondary prophylaxis (SP: NSBB = 200, non-NSBB = 67). The NSBB group was divided into low-dose (≤ 80 mg/day) and high-dose ...
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#1Se Ri RyuH-Index: 1
#2Jeong-Ju YooH-Index: 16
Last. Baigal BaymbajavH-Index: 2
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Background & Aims The hepatic venous pressure gradient (HVPG) reflects portal hypertension, but its measurement is invasive. Transient elastography (TE) is a noninvasive method for evaluating liver stiffness (LS). We investigated the correlation between the value of LS, liver stiffness to platelet ratio (LPR), LS-spleen diameter-to-platelet ratio score (LSPS) and HVPG according to the etiology of cirrhosis, especially focused on alcoholic cirrhosis. Methods Between January 2008 and March 2017, 5...
2 CitationsSource
#1Yoo Li Lim (Yonsei University)H-Index: 7
#2Young Woo Eom (Yonsei University)H-Index: 17
Last. Moon Young Kim (Yonsei University)H-Index: 32
view all 8 authors...
Background and objectives Autologous or allogeneic bone marrow-derived mesenchymal stem cells (BMSCs) have been applied in clinical trials to treat liver disease. However, only a few studies are comparing the characteristics of autologous MSCs from patients and allogeneic MSCs from normal subjects. Methods and results We compared the characteristics of BMSCs (BCs and BPs, respectively) isolated from six healthy volunteers and six patients with cirrhosis. In passage 3 (P3), senescent population a...
1 CitationsSource
#1Ji Hyun Kim (Kangwon National University)H-Index: 3
#2Seong Hee Kang (Yonsei University)H-Index: 10
Last. Ki Tae Suk (Sacred Heart Hospital)H-Index: 26
view all 13 authors...
Background and Aim: Previous studies reported that serum myostatin is associated with sarcopenia. We aimed to elucidate the association between serum myostatin levels and hepatocellular carcinoma (HCC) development in patients with alcoholic liver cirrhosis (ALC). Methods: This retrospective, multicenter study assessed 1077 Asian ALC patients enrolled from 2007 to 2017. The primary endpoint was the development of HCC within 5 years. Cox proportional hazards model analyses were used to assess the ...
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#1Taeui Hong (Yonsei University)H-Index: 1
#2Moon Young KimH-Index: 32
Last. Soon Koo BaikH-Index: 42
view all 7 authors...
Although mitochondrial functions are essential for cell survival, their critical roles in stem cell fate, including proliferation, differentiation, and senescence, remain elusive. Ginsenoside Rg3 exhibits various biological activities and reportedly increases mitochondrial biogenesis and respiration. Herein, we observed that Rg3 increased proliferation and suppressed senescence of human bone marrow-derived mesenchymal stem cells. Osteogenic, but not adipogenic, differentiation was facilitated by...
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#1Young Chang (SCH: Soonchunhyang University)H-Index: 3
#2Ki Tae Suk (Hallym University)H-Index: 26
Last. Jae Young Jang (SCH: Soonchunhyang University)H-Index: 32
view all 13 authors...
Background/aim: We aimed to derive a model representing the dynamic status of cirrhosis and to discriminate patients with poor prognosis even if the Model for End-Stage Liver Disease (MELD) score is low. Methods: This study retrospectively enrolled 700 cirrhotic patients with a MELD score of less than 20 who underwent hepatic venous pressure gradient (HVPG) measurement. A model named H6C score (= HVPG + 6 × CTP score) to predict overall survival was derived and internal and external validations ...
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#1Ji Hyun Kim (Kangwon National University)H-Index: 3
#2Seong Hee Kang (Yonsei University)H-Index: 10
Last. Dong Joon Kim (Sacred Heart Hospital)H-Index: 27
view all 13 authors...
BACKGROUND AND AIMS Current guidelines for chronic hepatitis B (CHB) patients are to undergo surveillance for hepatocellular carcinoma (HCC) with 6-month ultrasonography. We aimed to compare detection rates of very-early-stage HCC in two groups: group A, undergoing 6-month ultrasonography versus group B, undergoing 6-month ultrasonography alternating with dynamic computed tomography (CT). METHODS This retrospective study assessed 2151 CHB patients under entecavir/tenofovir therapy from 2007 to 2...
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