David F. Keane
Leeds Teaching Hospitals NHS Trust
Internal medicineSurgeryNursingRenal functionHealth careAdipose tissueIntensive care medicinePatient participationHemodialysisDialysisUrineTarget weightWater-Electrolyte BalanceNuclear medicineFluid managementIn patientObjective assessmentBioelectrical impedance analysisBlood volumeGold standard (test)MalnutritionUltrafiltrationMedicineCohortBody water
18Publications
7H-index
82Citations
Publications 17
Newest
#1Susanne Kron (Charité)H-Index: 7
#2Daniel Schneditz (Medical University of Graz)H-Index: 35
Last. Joachim KronH-Index: 7
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Online hemodiafiltration machines equipped with a blood volume monitor and the possibility to rapidly infuse exact amounts of ultra-pure dialysate into the extracorporeal circulation can be used to determine absolute blood volume in clinical practice. The aim of the present study was to evaluate the reproducibility of such measurements. Intra-individual reproducibility was evaluated in four measurements taken in hourly intervals within the same dialysis treatment. Ten patients were studied. Abso...
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#1David F. Keane (Leeds Teaching Hospitals NHS Trust)H-Index: 7
#2Megan Glyde (University of Leeds)H-Index: 1
Last. Ed Sutherland (University of Leeds)H-Index: 5
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BACKGROUND Decisions around planned ultrafiltration volumes are the only part of the haemodialysis prescription decided upon at every session. Removing too much fluid or too little is associated with both acute symptoms and long-term outcomes. The degree to which patients engage with or influence decision-making is not clear. We explored patient perspectives of prescribing ultrafiltration volumes, their understanding of the process and engagement with it. METHODS A questionnaire developed for th...
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#1Jenny Stenberg (Uppsala University)H-Index: 4
#2David F. KeaneH-Index: 7
Last. Hans Furuland (Uppsala University)H-Index: 10
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BackgroundAbout a third of patients undergoing haemodialysis have poorly controlled fluid status, which may affectsurvival. Clinical assessment is subjective and imprecise, which has led to the inc ...
2 CitationsSource
#1Megan GlydeH-Index: 1
#2David F. KeaneH-Index: 7
Last. Ed SutherlandH-Index: 1
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BACKGROUND: Person-centred care is increasingly promoted, empowering patients to become more involved in their treatment rather than being passive recipients of care (Barnes et al. 2013). Haemodialysis is typically required three times a week, with fluid management decision-making occurring at each treatment session (Ahmed et al. 2017). However, no research has yet explored how haemodialysis patients' perceptions of their fluid management may impact upon this decision-making. OBJECTIVES: This st...
4 CitationsSource
#1Tania Telford (Leeds Teaching Hospitals NHS Trust)H-Index: 1
#2David F. Keane (Leeds Teaching Hospitals NHS Trust)H-Index: 7
Last. Mark C. Barnfield (Leeds Teaching Hospitals NHS Trust)H-Index: 7
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AbstractGuidelines state that patients undergoing isotope glomerular filtration rate (GFR) tests should maintain adequate hydration, but pragmatically these tests can coincide with procedures requiring the patient not to eat or drink (‘nil-by-mouth’) for up to 12 hours beforehand. This study investigated the impact of a 12-hour nil-by-mouth regime on GFR measurement. Twelve healthy volunteers were recruited from our institution. Exclusion criteria included diabetes mellitus, being under 18 years...
1 CitationsSource
#1Indranil Dasgupta (University of Birmingham)H-Index: 30
#2David F. Keane (Leeds Teaching Hospitals NHS Trust)H-Index: 7
Last. Elizabeth Lindley (Leeds Teaching Hospitals NHS Trust)H-Index: 17
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1 CitationsSource
#1David F. Keane (Leeds Teaching Hospitals NHS Trust)H-Index: 7
#2Paul D. Baxter (University of Leeds)H-Index: 20
Last. Sue Pavitt (University of Leeds)H-Index: 28
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Relative blood volume (RBV) monitoring during hemodialysis has been used to help guide fluid management for decades, although with little supporting evidence. The technique relies on the assumption that variation in RBV during fluid removal reflects the capacity for vascular refilling and that efficient refilling is related to fluid overload. This study investigated the relationship between RBV variation and bioimpedance-based fluid overload in 47 patients on stable hemodialysis. Mean treatment ...
9 CitationsSource
#1Indranil Dasgupta (University of Birmingham)H-Index: 30
#2David F. Keane (Leeds Teaching Hospitals NHS Trust)H-Index: 7
Last. Ulrich Moissl (Fresenius Medical Care)H-Index: 16
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Background Bioimpedance spectroscopy (BIS) with a whole-body model to distinguish excess fluid from major body tissue hydration can provide objective assessment of fluid status. BIS is integrated into the Body Composition Monitor (BCM) and is validated in adults, but not children. This study aimed to (1) assess agreement between BCM-measured total body water (TBW) and a gold standard technique in healthy children, (2) compare TBW_BCM with TBW from Urea Kinetic Modelling (UKM) in haemodialysis ch...
15 CitationsSource
#1David F. Keane (Leeds Teaching Hospitals NHS Trust)H-Index: 7
#2Kim BowraH-Index: 1
Last. Elizabeth LindleyH-Index: 17
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Most hemodialysis (HD) patients are able to finish dialysis at or below the normally hydrated weight determined using the body composition monitor (BCM). However, a minority become symptomatic when they are still fluid overloaded based on BCM-measured overhydration (OH). Malnourished patients frequently fall into this group, suggesting that they may have OH that is inaccessible to ultrafiltration. To isolate any effect of malnutrition on BCM-measured OH from those relating to renal failure, OH m...
6 CitationsSource
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