Frederick F. Lang
University of Texas MD Anderson Cancer Center
CancerInternal medicineSurgeryPathologyOncologyMolecular biologyMesenchymal stem cellImmunologyIn vivoGlioblastomaOncolytic adenovirusGliomaBrain tumorStem cellCancer researchRadiation therapyMedicineCell cultureOncolytic virusBiologyImmune system
272Publications
76H-index
17.1kCitations
Publications 273
Newest
#1Juan Fueyo (University of Texas MD Anderson Cancer Center)H-Index: 58
#2Candelaria Gomez-Manzano (University of Texas MD Anderson Cancer Center)H-Index: 50
Last. Marta M. AlonsoH-Index: 36
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#1Hila Shaim (University of Texas MD Anderson Cancer Center)H-Index: 14
#2Mayra Shanley (University of Texas MD Anderson Cancer Center)H-Index: 3
Last. Konrad Gabrusiewicz (University of Texas MD Anderson Cancer Center)H-Index: 23
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Glioblastoma, the most aggressive brain cancer, recurs because glioblastoma stem cells (GSCs) are resistant to all standard therapies. We showed that GSCs, but not normal astrocytes, are sensitive to lysis by healthy allogeneic natural killer (NK) cells in vitro. Mass cytometry and single cell RNA sequencing of primary tumor samples revealed that glioblastoma-infiltrating NK cells acquired an altered phenotype associated with impaired lytic function relative to matched peripheral blood NK cells ...
4 CitationsSource
#1Travis C. Salzillo (University of Texas MD Anderson Cancer Center)H-Index: 5
#2Vimbai Mawoneke (University of Texas MD Anderson Cancer Center)
Last. Christopher J. Logothetis (University of Texas MD Anderson Cancer Center)H-Index: 85
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Rapid diagnosis and therapeutic monitoring of aggressive diseases such as glioblastoma can improve patient survival by providing physicians the time to optimally deliver treatment. This research tested whether metabolic imaging with hyperpolarized MRI could detect changes in tumor progression faster than conventional anatomic MRI in patient-derived glioblastoma murine models. To capture the dynamic nature of cancer metabolism, hyperpolarized MRI, NMR spectroscopy, and immunohistochemistry were p...
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#1Lynette Phillips (University of Texas MD Anderson Cancer Center)H-Index: 4
#2Shoudong Li (University of Texas MD Anderson Cancer Center)H-Index: 1
Last. Frederick F. Lang (University of Texas MD Anderson Cancer Center)H-Index: 76
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BACKGROUND Oncolytic adenoviruses are promising new treatments against solid tumors, particularly for glioblastoma (GBM), and preclinical models are required to evaluate the mechanisms of efficacy. However, due to the species selectivity of adenovirus, there is currently no single animal model that supports viral replication, tumor oncolysis, and a virus-mediated immune response. To address this gap, we took advantage of the Syrian hamster to develop the first intracranial glioma model that is b...
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#1Francesca Puca (University of Texas MD Anderson Cancer Center)H-Index: 2
#2Fei Yu (University of Texas MD Anderson Cancer Center)
Last. Giulio Draetta (University of Texas MD Anderson Cancer Center)H-Index: 71
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Glioblastoma (GBM) is highly resistant to chemo- and immune-based therapies and targeted inhibitors. To identify novel drug targets, we screened orthotopically implanted, patient-derived glioblastoma sphere-forming cells (GSCs) using an RNAi library to probe essential tumor cell metabolic programs. This identified high dependence on mitochondrial fatty acid metabolism. We focused on medium-chain acyl-CoA dehydrogenase (MCAD), which oxidizes medium-chain fatty acids (MCFAs), due to its consistent...
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#1Visish M. Srinivasan (BCM: Baylor College of Medicine)H-Index: 13
#2Caroline Hadley (BCM: Baylor College of Medicine)H-Index: 10
Last. Daniel Yoshor (BCM: Baylor College of Medicine)H-Index: 23
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The development of neurosurgery at Baylor College of Medicine began with the medical school's relocation to the new Texas Medical Center in Houston in 1943. An academic service was organized in 1949 as a section of neurosurgery within Baylor's Department of Surgery. Soon the practice, led by Dr. George Ehni, evolved to include clinical services at Methodist, Jefferson Davis (forerunner of Ben Taub), Texas Children's, the Veterans Affairs, and the University of Texas MD Anderson Cancer Center hos...
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#1E. Antonio Chiocca (Brigham and Women's Hospital)H-Index: 79
#2Frederick F. Lang (University of Texas MD Anderson Cancer Center)H-Index: 76
Last. James M. Markert (UAB: University of Alabama at Birmingham)H-Index: 47
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#1Chibawanye I. EneH-Index: 12
#2Juan Fueyo (University of Texas MD Anderson Cancer Center)H-Index: 58
Last. Frederick F. LangH-Index: 47
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Delta-24-based oncolytic viruses are conditional replication adenoviruses developed to selectively infect and replicate in retinoblastoma 1 (Rb)-deficient cancer cells but not normal cell with intact Rb1 pathways. Over the years, there has been a significant evolution in the design of Delta-24 based on a better understanding of the underlying basis for infection, replication, and spread within cancer. One example is the development of Delta-24-RGD (DNX-2401), where the arginine-glycine-aspartate...
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