Toshiyuki Kita
St. Marianna University School of Medicine
Internal medicineEndocrinologySurgeryPathologyOncologyChemistryImmunologyAllergyAsthmaBronchial hyperresponsivenessLung cancerChemotherapyInhalationLungBronchoalveolar lavageGefitinibBronchoconstrictionMethacholineCarboplatinNon small cellPhases of clinical researchAnesthesiaMedicinePharmacology
Publications 68
#1Kazuo KasaharaH-Index: 28
#2Hideharu KimuraH-Index: 21
Last. Shinji NakaoH-Index: 59
view all 17 authors...
Background: The aim of this phase II study was to evaluate the efficacy of combination chemotherapy consisting of docetaxel and carboplatin in patients with inoperable non- small cell lung cancer (NSCLC). Patients and Methods: For this multicenter phase II study, the eligibility criteria included histologically or cytologically proven inoperable NSCLC, measurable lesions, Eastern Cooperative Oncology Group performance status (PS) 0-2, adequate organ and bone marrow functions, and written informe...
6 Citations
: The 1st case was a 74-year-old male diagnosed as femoral neck fracture. Biopsy of the bone revealed metastatic adenocarcinoma. Chest computed tomography (CT) showed a mass lesion located in the right lower lobe. With a diagnosis of primary lung cancer (cT2N1M1), two-staged operation was performed. Pathological diagnosis was pleomorphic carcinoma [pT2N1M1 (OSS), stage IV]. He died 8 months after surgery due to metastasis to the thoracic spine. The 2nd case was a 80-year-old female who complaine...
2 Citations
#1Hideharu Kimura (Kanazawa University)H-Index: 21
#2Kazuo KasaharaH-Index: 28
Last. Shinji NakaoH-Index: 59
view all 20 authors...
Background The authors evaluate the efficacy and safety of gefitinib monotherapy in chemotherapy-naive patients with advanced non–small-cell lung cancer (NSCLC). A secondary endpoint is to evaluate the relationship between clinical manifestations and epidermal growth factor receptor ( EGFR ) mutation status. Methods Japanese chemotherapy-naive NSCLC patients were enrolled. They had measurable lesions, Eastern Cooperative Oncology Group performance status of 0 to 2, and adequate organ and bone ma...
91 CitationsSource
#1Kazuo Kasahara (Kanazawa University)H-Index: 28
#2Kazuhiro ShibataH-Index: 1
Last. Shinji NakaoH-Index: 59
view all 17 authors...
To determine the optimum dose of OK-432 for intrathoracic administration, a multicenter randomized phase II trial was conducted in patients with malignant pleural effusion due to non-small cell lung cancer. Patients with histologically- or cytologically-proven malignant pleural effusions were randomized to arm A (10 Klinische Einheit (KE) of OK-432) or arm B (1 KE of OK-432). OK-432 was injected intrapleurally over 30 min on days 1 and 3 and the chest tube was clamped for 6 h. If control was ina...
21 Citations
#1Yuichi TamboH-Index: 5
#2Toshiyuki KitaH-Index: 15
Last. Shinji NakaoH-Index: 59
view all 6 authors...
背景.偽中皮腫性肺癌(pseudomesotheliomatous carcinoma of the lung:PMCL)は,臓側胸膜へのびまん性浸潤を特徴とし,組織学的に末梢性肺癌であることが確認されるものと定義される.今回我々はPMCLと診断した1剖検例を経験したので報告する.症例.71歳男性.2003年5月右胸痛,呼吸困難を主訴に外来受診し,胸部単純写真にて右側胸水を認め,入院となった.胸水細胞診にて腺癌細胞が検出され,全身検査の結果,肺腺癌(cT4N3M0 stage IIIB)と診断した.胸腔ドレナージ後,化学療法を繰り返し行ったが,診断から16ヶ月の経過で腫瘍死した.剖検の結果,右肺内には腫瘍性病変を認めなかったが,肺全体を取り囲むように胸膜は肥厚していた.臓側胸膜に沿った部位に癌組織を認め,免疫染色にてCEA, TTF-1陽性,calretinin陰性,であり,PMCLと診断した.結論.肺内の原発巣が不明な悪性胸水の症例においては,PMCLも念頭におき,胸水細胞診のみではなく可能な限り免疫組織学的検査も行うことが必要であると考えられた.
2 CitationsSource
#1Johsuke Hara (Kanazawa University)H-Index: 12
#2Masaki Fujimura (Kanazawa University)H-Index: 53
Last. Shinji Nakao (Kanazawa University)H-Index: 59
view all 17 authors...
Background Late asthmatic response is observed following antigen challenge in actively, but not passively, sensitized guinea pigs. Although cough reflex sensitivity is increased after antigen challenge in actively sensitized guinea pigs, it is unknown whether the antigen-induced increase in cough reflex sensitivity develops in passively sensitized animals. The aim of this study was to compare the cough reflex sensitivity to inhaled capsaicin after an inhaled antigen challenge between actively an...
8 CitationsSource
#1Kazuhiko ShibataH-Index: 13
#2Kazuo KasaharaH-Index: 28
Last. Shinji NakaoH-Index: 59
view all 10 authors...
#1Takashi SoneH-Index: 12
#2Kazuhiko ShibataH-Index: 13
Last. Shinji NakaoH-Index: 59
view all 11 authors...
7294 Background: While the prognosis for LA-NSCLC has improved, satisfactory results have not been obtained. Therapeutic outcomes for radiotherapy combined with low-dose of CDDP were significantly ...
#1Yoshitaka Oribe (Kanazawa University)H-Index: 9
#2Masaki Fujimura (Kanazawa University)H-Index: 53
Last. Shinji Nakao (Kanazawa University)H-Index: 59
view all 8 authors...
Summary Background Gastrooesophageal reflux (GER) is a frequent cause of chronic cough. Several investigators have indicated that inhibitors of H+K+ATPase (proton pump inhibitors; PPIs) could relieve coughing via inhibition of acid reflux. However, we considered that PPIs might directly inhibit increased cough reflex sensitivity. Objective The present study was designed to examine whether PPIs directly inhibit antigen-induced increase in cough reflex sensitivity and to elucidate the mechanism. M...
16 CitationsSource
#1Tomokazu Yoshizaki (Kanazawa University)H-Index: 39
#2Hidenori Kinsen (Kanazawa University)H-Index: 2
Last. Mitsuru Furukawa (Kanazawa University)H-Index: 37
view all 5 authors...
Metastasis is a feature of malignant neoplasms. Although rare, metastasizing pathologically benign mixed tumour has been reported. This report describes a 33-year-old woman with multiple lung metastases from mixed tumour. A small preauricular mass had been removed 23 years earlier. Six years later, the patient had the same symptom; the recurrent mass was resected. She was not aware of the exact pathological diagnosis of the previous tumours. One of the most common features of metastasizing mixed...
13 CitationsSource