Alessandro Zerbi
Humanitas University
CancerInternal medicineRadiologySurgeryPathologyOncologyRetrospective cohort studyProspective cohort studyPancreatitisPancreatic diseasePancreatectomyPancreasPancreaticoduodenectomyPancreatic cancerPancreatic fistulaAdenocarcinomaPancreatic surgeryCancer researchGeneral surgeryMedicineBiologyGastroenterology
Publications 307
#1Gennaro NappoH-Index: 6
#2Domenico Borzomati (Università Campus Bio-Medico)H-Index: 19
Last. Damiano Caputo (Università Campus Bio-Medico)H-Index: 14
view all 16 authors...
Background There is extreme heterogeneity in the available literature on the determination of R1 resection rate after pancreatoduodenectomy (PD); consequently, its prognostic role is still debated. The aims of this multicenter randomized study were to evaluate the effect of sampling and clearance definition in determining R1 rate after PD for periampullary cancer and to assess the prognostic role of R1 resection. Methods PD specimens were randomized to Leeds Pathology Protocol (LEEPP) (group A) ...
#1Giovanni Capretti (Humanitas University)H-Index: 16
#2Greta DonisiH-Index: 2
Last. Alessandro Zerbi (Humanitas University)H-Index: 57
view all 7 authors...
PURPOSE Patients with fistula risk score (FRS) ≥7 are at the highest risk of developing clinically relevant post-operative pancreatic fistula (CR-POPF). There is no agreement on the management of this subpopulation. The primary outcome of the study was the definition of the role of intraoperative completion pancreatectomy (ICP) in patients at high risk for CR-POPF, as an alternative to high-risk pancreaticoduodenectomy (PD). METHODS This is an observational study set in a single tertiary referra...
#1Gennaro NappoH-Index: 6
#2Jacopo Galvanin (Humanitas University)H-Index: 2
Last. Alessandro Zerbi (Humanitas University)H-Index: 57
view all 12 authors...
Abstract Background Ampullary carcinoma (AC) is histologically classified as intestinal (In-AC), pancreaticobiliary (Pb-AC) or mixed-AC. The prognostic role of AC subtypes has been debated and remains unclear. The aims of this study were to evaluate outcomes after pancreatoduodenectomy (PD) for each subtype of AC and to compare these with pancreatic ductal adenocarcinoma [PDAC] and distal cholangiocarcinoma [DCC]. Methods PDs performed for AC between 2010 and 2018 were retrospectively evaluated....
#1S. Lof (University of Southampton)H-Index: 6
#2N van der Heijde (UvA: University of Amsterdam)
Last. U Wellner
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BACKGROUND The role of minimally invasive distal pancreatectomy is still unclear, and whether robotic distal pancreatectomy (RDP) offers benefits over laparoscopic distal pancreatectomy (LDP) is unknown because large multicentre studies are lacking. This study compared perioperative outcomes between RDP and LDP. METHODS A multicentre international propensity score-matched study included patients who underwent RDP or LDP for any indication in 21 European centres from six countries that performed ...
#1Eleonora Vitali (Humanitas University)H-Index: 8
#1E. Vitali (Humanitas University)
Last. Andrea Lania (Humanitas University)H-Index: 13
view all 8 authors...
Pancreatic neuroendocrine tumors (Pan-NETs), are heterogeneous neoplasms, whose incidence and prevalence are increasing worldwide. Pan-NETs are characterized by the expression of somatostatin receptors (SSTs). In particular, SST2 is the most widely distributed SST in NETs, thus representing the main molecular target for somatostatin analogs (SSAs). SSAs are currently approved for the treatment of well-differentiated NETs, and radionuclide-labeled SSAs are used for diagnostic and treatment purpos...
#1Roberta Elisa Rossi (University of Milan)H-Index: 26
#3Anna Caterina Milanetto (UNIPD: University of Padua)H-Index: 9
Last. Sara Massironi (University of Milan)H-Index: 26
view all 18 authors...
Purpose Pretreatment staging is the milestone for planning either surgical or endoscopic treatment in duodenal neuroendocrine neoplasms (dNENs). Herein, a series of surgically treated dNEN patients was evaluated to assess the concordance between the pre- and postsurgical staging. Methods Retrospective analysis of patients with a histologically confirmed diagnosis of dNENs, who underwent surgical resection observed at eight Italian tertiary referral centers. The presurgical TNM stage, based on th...
#1Gaëtan-Romain Joliat (UNIL: University of Lausanne)H-Index: 12
#2Pierre Allemann (UNIL: University of Lausanne)H-Index: 20
Last. Markus Schäfer (UNIL: University of Lausanne)H-Index: 40
view all 13 authors...
Abstract Background Resection margin status and lymph node (LN) involvement are known prognostic factors for patients who undergo pancreatoduodenectomy for pancreatic ductal adenocarcinoma (PDAC). This study aimed to compare overall survival (OS) and disease-free survival (DFS) by resection margin status in patients with PDAC and LN involvement. Methods A retrospective international multicentric study was performed including four Western centers. Multivariable Cox analysis was performed to ident...
#2Ismail LabgaaH-Index: 15
Last. Markus SchäferH-Index: 40
view all 14 authors...
#1Francesca GavazziH-Index: 11
Last. Alessandro Zerbi (Humanitas University)H-Index: 57
view all 6 authors...
INTRODUCTION Into blood relatives of patients affected by breast cancer, the prevalence of pancreatic ductal adenocarcinoma (PDAC) seems to be elevated. BRCA1/2 mutations as other VUS (variants of uncertain significance) could be responsible. METHODS We retrospectively revised dataset of Pancreatic Surgery Unit of Humanitas Clinical and Research Center - IRCCS and identified patients who underwent resection for PDAC between 2010 and 2018. We evaluated neoplastic family history and remote patholo...