Hideharu Kimura
Kanazawa University
CancerInternal medicinePathologyOncologyMolecular biologyImmunologyLung cancerChemotherapyCarcinomaLungT790MEpidermal growth factor receptorGefitinibAdenocarcinomaNon small cellMutationCancer researchMedicineCell cultureBiologyCancer cell
150Publications
21H-index
2,198Citations
Publications 134
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#1Hayato Koba (Kanazawa University)H-Index: 5
#2Hideharu Kimura (Kanazawa University)H-Index: 21
Last. Kazuo Kasahara (Kanazawa University)H-Index: 28
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In cancer patients, circulating cell-free DNA (cfDNA) includes tumor-derived DNA (tDNA). cfDNA has been used clinically for non-invasive gene mutation testing. The aim of this study was to characterize the features of the genetic alterations detected in cfDNA. This study included 6 patients with primary lung cancer who died due to cancer progression. Tumors were biopsied at autopsy. Genetic alteration profiles were obtained using next generation sequencing. The features of the tDNA genetic alter...
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#1Hideharu KimuraH-Index: 21
#2Takashi SoneH-Index: 12
Last. Kazuo KasaharaH-Index: 28
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Awareness of the immune-related adverse event of programmed cell death protein-1 (PD-1) inhibitor-induced pneumonitis is important. Herein, we report the clinical course of 3 patients suspected to have PD-1 inhibitor-induced pneumonitis after cessation of PD-1 inhibitor treatment. In case 1, a 62-year-old man was diagnosed with stage IVA adenocarcinoma. Nivolumab monotherapy was prescribed as second-line therapy and later discontinued due to financial reasons. Seven months after the final admini...
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#1Kazumasa KaseH-Index: 1
#2Satoshi WatanabeH-Index: 11
Last. Johsuke HaraH-Index: 12
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#1Tomoyuki ArayaH-Index: 7
#2Toshiyuki KitaH-Index: 15
Last. Kazuo KasaharaH-Index: 28
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A standard chemotherapy regimen for advanced thymic carcinoma has not yet been established. We treated 2 cases of thymic carcinoma with carboplatin plus nanoparticle albumin-bound (nab)-paclitaxel, and nab-paclitaxel maintenance therapy. The first case was a 68-year-old female, admitted for dyspnea and left shoulder pain. Chest computed tomography (CT) showed a huge mass in the anterior mediastinum, pleural and pericardial effusions, and multiple lung metastases. Specimens obtained from the ante...
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#1Noriyuki Ohkura (Kanazawa University)H-Index: 15
#2Masaki FujimuraH-Index: 53
Last. Kazuo Kasahara (Kanazawa University)H-Index: 28
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Abstract Background Cough variant asthma (CVA) is the most common cause of chronic cough and responds well to bronchodilator therapy. Previous studies on methacholine -induced cough have shown that heightened cough response due to bronchoconstriction is a feature of CVA. The aim of this study was to assess Mch-induced cough as an indicator of bronchodilator-responsive cough (BRC). Methods This was a single-center retrospective study of prolonged/chronic cough cases who underwent evaluation via s...
1 CitationsSource
#1Hayato Koba (Kanazawa University)H-Index: 5
#2Taro Yoneda (Kanazawa University)H-Index: 4
Last. Kazuo Kasahara (Kanazawa University)H-Index: 28
view all 6 authors...
The combination therapy of Lopinavir/Ritonavir plus Favipiravir might be a treatment option for patients with COVID-19. Serum ferritin levels and lymphocytopenia are promising markers for disease severity and disease progression that are commonly available in general clinical practice.
1 CitationsSource
#1Yasushi YatabeH-Index: 106
#2Kuniko SunamiH-Index: 12
Last. Hirotoshi Dosaka-Akita (Hokkaido University)H-Index: 55
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The year 2019 was considered to be the first year of cancer genome medicine in Japan, with three gene-panel tests using next-generation sequencing (NGS) techniques being introduced into clinical practice. Among the three tests, the Oncomine CDx Target test was approved under the category of regular molecular testing for lung cancer, which meant that this test could be used to select patients for molecularly targeted drugs. Conversely, the other two tests, NCC OncoPanel and FoundationOne CDx, wer...
1 CitationsSource