William Ngo
University of Waterloo
OphthalmologyOptometryInternal medicineBiomedical engineeringSurgeryRepeatabilityDermatologyChemistryMaterials scienceLens (optics)Meibomian glandAsymptomaticTearsArtificial tearsDemodexRetinalEyelidOcular Surface Disease IndexMeibomian gland dysfunctionContact lensSignificant differenceSigns and symptomsDaily disposableCorneal edemaOcular surfaceChromatographyHygieneMedicineSensory systemPharmacology
56Publications
8H-index
267Citations
Publications 57
Newest
#1Yuqiang Bai (UAB: University of Alabama at Birmingham)H-Index: 8
#2William Ngo (UW: University of Waterloo)H-Index: 8
Last. Jason J. Nichols (UAB: University of Alabama at Birmingham)H-Index: 57
view all 0 authors...
Source
#1Safal Khanal (UAB: University of Alabama at Birmingham)H-Index: 7
#2Yuqiang Bai (UAB: University of Alabama at Birmingham)H-Index: 8
Last. Jason J. Nichols (UAB: University of Alabama at Birmingham)H-Index: 57
view all 7 authors...
Purpose To investigate the association between precorneal tear film (PCTF)- and meibum-derived (O-Acyl)-omega-hydroxy fatty acids (OAHFAs) and PCTF thinning in meibomian gland health and dysfunction. Methods Of 195 eligible subjects (18-84 years, 62.6% female), 178 and 170 subjects provided both PCTF optical coherence tomography (OCT) imaging and mass spectrometry data for tears (n = 178) and meibum (n = 170). The PCTF thinning rate was measured in the right eye using an ultra-high-resolution, c...
Source
#1Vivian Wing-Sheung Chan (UW: University of Waterloo)H-Index: 3
#2Chau-Minh Phan (UW: University of Waterloo)H-Index: 10
Last. Lyndon Jones (UW: University of Waterloo)H-Index: 69
view all 5 authors...
Purpose The purpose of this study was to evaluate the effects of temperature and blinking on contact lens (CL) dehydration using an in vitro blink model. Methods Three silicone hydrogel (delefilcon A, senofilcon A, and comfilcon A) and two conventional hydrogel (etafilcon A and omafilcon A) CL materials were evaluated at 1 and 16 hours. The water content (WC) of the CLs was measured using a gravimetric method. Lenses were incubated on a blink model, internally heated to achieve a clinically rele...
Source
#1Safal Khanal (UAB: University of Alabama at Birmingham)H-Index: 7
#2Yuqiang Bai (UAB: University of Alabama at Birmingham)H-Index: 8
Last. Jason J. Nichols (UAB: University of Alabama at Birmingham)H-Index: 57
view all 7 authors...
#1Mike Yang (UW: University of Waterloo)H-Index: 1
#2William Ngo (UW: University of Waterloo)H-Index: 8
Last. Michelle Senchyna (DuPont)H-Index: 19
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Abstract The purpose of this study was to develop a standardized, accurate and efficient method for estimating conjunctival goblet cell density (GCD) via optimizing sample storage conditions and quantification methods. Conjunctival impression cytology (CIC) membranes were collected from both eyes of 32 participants and were randomized to two storage durations (2–3 weeks, 6–7 weeks) and two storage container types (microcentrifuge tube, flat histology cassette). The CIC membranes were stained and...
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PURPOSE To quantify the effect of spectacle frame dimensions on wind-induced ocular plane evaporation. METHODS A drop of 0.5 μL water was pipetted onto an eye of a mannequin head. The face was fitted with a spectacle frame. A fan positioned 10 cm away directed air (185 CFM) toward the face and the time required for the drop to evaporate was recorded. This procedure was repeated with 31 different frames to obtain evaporation times for various eye sizes, vertical heights, vertex distances, tempera...
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#1Katsuhide YamasakiH-Index: 3
#2Elizabeth Drolle (UW: University of Waterloo)H-Index: 9
Last. Lyndon Jones (UW: University of Waterloo)H-Index: 69
view all 6 authors...
Abstract Purpose To investigate the interaction of a novel low molecular weight hyaluronic acid derivative containing hydrophobic groups with soft contact lenses and its effect on lens hydrophilicity compared with a conventional form of hyaluronic acid. Methods This investigation studied the uptake of fluorescently-labelled hyaluronic acid and a low molecular weight hyaluronic acid derivative to four types of contact lenses using fluorescent microscopy and confocal laser scanning microscopy. Fur...
4 CitationsSource
#1Safal Khanal (UAB: University of Alabama at Birmingham)H-Index: 7
#2William Ngo (UW: University of Waterloo)H-Index: 8
Last. Jason J. Nichols (UAB: University of Alabama at Birmingham)H-Index: 57
view all 6 authors...
PURPOSE The molecular basis of the tear film and lipid layer alterations in meibomian gland dysfunction (MGD) is unknown. This study aimed to identify and compare (O-acyl)-omega-hydroxy fatty acids (OAHFAs) derived from human meibum and tears in MGD. METHODS Of 195 eligible subjects (18-84 years, 62.6% female), 183 and 174 provided samples for tears and meibum, respectively. Subjects were classified into four groups: Normal, Asymptomatic MGD, MGD, and Mixed. Samples from the right eye of each su...
1 CitationsSource
#1Vivian Wing-Sheung Chan (UW: University of Waterloo)H-Index: 3
#2Chau-Minh PhanH-Index: 10
Last. Lyndon JonesH-Index: 69
view all 4 authors...
PURPOSE To evaluate active lysozyme deposition on daily disposable (DD) contact lenses (CL) using a novel in vitro blink model. METHODS Three conventional hydrogel DD CL materials (etafilcon A, omafilcon A, nelfilcon A) and three silicone hydrogel DD CL materials (delefilcon A, senofilcon A, somofilcon A) were tested. The device blink rate was set to 6 blinks/min with a tear flow rate of 1 μL/min using an artificial tear solution (ATS) containing lysozyme and other typical tear film components. ...
Source
#1Laura E Downie (University of Melbourne)H-Index: 20
#2Stefan Bandlitz (Aston University)H-Index: 6
Last. James S. Wolffsohn (University of Auckland)H-Index: 61
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Abstract A key element of contact lens practice involves clinical evaluation of anterior eye health, including the cornea and limbus, conjunctiva and sclera, eyelids and eyelashes, lacrimal system and tear film. This report reviews the fundamental anatomy and physiology of these structures, including the vascular supply, venous drainage, lymphatic drainage, sensory innervation, physiology and function. This is the foundation for considering the potential interactions with, and effects of, contac...
8 CitationsSource