Toshiaki Utsunomiya
Yamaguchi University
Vascular permeabilityFragment crystallizable regionInternal medicineFunction (biology)OncologyAntibodyDermatologyMortality rateTumor necrosis factor alphaChemistryAdverse effectGlycanObservational studyAsthmaFucosePerformance statusInflammationGlycosylationInterstitial lung diseaseHeparinOsimertinibAsymptomaticT790MIdiopathic pulmonary fibrosisCytokineDiscontinuationPneumonitisCritical quality attributesGefitinibEndoglycosidaseMonocyteEGFR Gene MutationMedication PersistenceIn patientEndobronchial tuberculosisBiochemistryVital capacityMedicineInterleukinFibroblast growth factorPharmacology
Publications 5
#2Yuka Mimura-KimuraH-Index: 6
Last. Yusuke MimuraH-Index: 14
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Background: Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are episodes of acute respiratory worsening characterized by diffuse alveolar damage superimposed on usual interstitial pneumonia. Direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) is reported to have beneficial effects on the respiratory status and outcome in patients with AE-IPF although its mechanism of action is not fully elucidated. Objective: To investigate whether and how the PMX-immobilized...
#1Kenichi ChikamoriH-Index: 10
#2Tadashi MaedaH-Index: 15
Last. Haruhito KameiH-Index: 14
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Abstract Background Osimertinib is a key-drug to treat NSCLC harboring EGFR sensitizing mutation at 1st line setting as well as T790M resistant mutation at late line. Interstitial lung disease/pneumonitis (ILD) is a fatal adverse event induced by tyrosine kinase inhibitors including osimertinib especially in the Japanese patients. On the other hand, transient asymptomatic pulmonary opacities (TAPO) caused by osimertinib were reported as relatively frequent (10-20%) phenomenon and usually safe, p...
#1Keiji Oishi (Yamaguchi University)H-Index: 6
#2Tsunahiko Hirano (Yamaguchi University)H-Index: 22
Last. Masafumi Yano (Yamaguchi University)H-Index: 41
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Background:In patients with idiopathic pulmonary fibrosis (IPF), continuing treatment with antifibrotic agents is crucial to decrease the reduction of forced vital capacity and mortality rate. Howe...
2 CitationsSource
#1Yusuke MimuraH-Index: 14
#2Toshihiko Katoh (LMB: Laboratory of Molecular Biology)H-Index: 10
Last. Pauline M. RuddH-Index: 28
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Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex-type oligosaccharide attached to Asn297 of the Fc is essential for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that generate structural heterogeneity (glycoforms) exhibit unique biological activities. Hence, efficient and quantitative glycan analysis techniques have been increasingly important fo...
75 CitationsSource
#1Keiji OishiH-Index: 6
Last. Hiroshi UeokaH-Index: 35
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