Elena Cutrì
Polytechnic University of Milan
Porous mediumDistributed computingInternal medicineFluidicsFinite element methodBiomedical engineeringThroughput (business)SurgeryCardiologyHemodynamicsMaterials scienceArteryRestenosisStentVentricleDrug deliveryConstruct (python library)Drug elutionSide branchMain branchDrug releaseTorsion (mechanics)Flow (mathematics)Computer scienceSimulationMedicineMicrofluidicsFluid dynamics
16Publications
7H-index
119Citations
Publications 15
Newest
#1Elena Cutrì (Polytechnic University of Milan)H-Index: 7
#2Alessio Meoli (Polytechnic University of Milan)H-Index: 5
Last. Giancarlo Pennati (Polytechnic University of Milan)H-Index: 37
view all 6 authors...
Abstract Hypoplastic left heart syndrome is a complex congenital heart disease characterised by the underdevelopment of the left ventricle normally treated with a three-stage surgical repair. In this study, a multiscale closed-loop cardio-circulatory model is created to reproduce the pre-operative condition of a patient suffering from such pathology and virtual surgery is performed. Firstly, cardio-circulatory parameters are estimated using a fully closed-loop cardio-circulatory lumped parameter...
1 CitationsSource
#1Laura Iannetti (Polytechnic University of Milan)H-Index: 1
#2Giovanna D'Urso (Polytechnic University of Milan)H-Index: 1
Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 28
view all 8 authors...
Next generation bioreactors are being developed to generate multiple human cell-based tissue analogs within the same fluidic system, to better recapitulate the complexity and interconnection of human physiology [1, 2]. The effective development of these devices requires a solid understanding of their interconnected fluidics, to predict the transport of nutrients and waste through the constructs and improve the design accordingly. In this work, we focus on a specific model of bioreactor, with mul...
11 CitationsSource
#1Elena Cutrì (Polytechnic University of Milan)H-Index: 7
#2Marta Serrani (University of Cambridge)H-Index: 7
Last. Maria Laura Costantino (Polytechnic University of Milan)H-Index: 14
view all 5 authors...
The torsional behaviour of the heart (i.e. the mutual rotation of the cardiac base and apex) was proved to be sensitive to alterations of some cardiovascular parameters, i.e. preload, afterload and contractility. Moreover, pathologies which affect the fibers architecture and cardiac geometry were proved to alter the cardiac torsion pattern. For these reasons, cardiac torsion represents a sensitive index of ventricular performance. The aim of this work is to provide further insight into physiolog...
9 CitationsSource
#1Paolo Zunino (University of Pittsburgh)H-Index: 28
#2Josip Tambača (University of Zagreb)H-Index: 13
Last. Francesco Migliavacca (Polytechnic University of Milan)H-Index: 60
view all 6 authors...
Stent modeling represents a challenging task from both the theoretical and numerical viewpoints, due to its multi-physics nature and to the complex geometrical configuration of these devices. In this light, dimensional model reduction enables a comprehensive geometrical and physical description of stenting at affordable computational costs. In this work, we aim at reviewing dimensional model reduction of stent mechanics and drug release. Firstly, we address model reduction techniques for the des...
7 CitationsSource
Aug 1, 2015 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
#1Gaia Franzetti (Polytechnic University of Milan)
#2Federica Crippa (Polytechnic University of Milan)
Last. Giancarlo Pennati (Polytechnic University of Milan)H-Index: 37
view all 9 authors...
Melanocytic nevi are common benign skin lesions, known as moles, due to proliferation of melanocytes, the pigmented skin cells. The uncontrolled growth of these cells leads instead to cutaneous malignant melanoma, an aggressive tumour whose rate of survival dramatically increases if early diagnosis is provided. Alteration on the mechanical properties of the skin in presence of lesions has been assessed. In this context, we aim at developing a combined approach consisting of an experimental and a...
Source
#1Alessio Meoli (Polytechnic University of Milan)H-Index: 5
#2Elena Cutrì (Polytechnic University of Milan)H-Index: 7
Last. Giancarlo Pennati (Polytechnic University of Milan)H-Index: 37
view all 7 authors...
Complex congenital heart disease characterized by the underdevelopment of one ventricular chamber (single ventricle (SV) circulation) is normally treated with a three-stage surgical repair. This study aims at developing a multiscale computational framework able to couple a patient-specific three-dimensional finite-element model of the SV to a patient-specific lumped parameter (LP) model of the whole circulation, in a closed-loop fashion. A sequential approach was carried out: (i) cardiocirculato...
13 CitationsSource
Jan 1, 2015 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
#1Eros Montin (Polytechnic University of Milan)H-Index: 5
#2Elena Cutrì (Polytechnic University of Milan)H-Index: 7
Last. Luca T. Mainardi (Polytechnic University of Milan)H-Index: 36
view all 6 authors...
Several studies report the mechanical properties of skin tissues but their values largely depend on the measurement method. Therefore, we investigated the feasibility of recognizing the cellular constituents mechanical properties of pigmented skin by Confocal Laser Scanner Microscopy (CLSM). With this purpose, an healthy volunteer was examined in three areas nearby a pigmented skin lesion in two configurations: deforming and non deforming the nevus. The tissue displacement of the nevus was then ...
1 CitationsSource
#1Stefano MorlacchiH-Index: 12
#2Claudio ChiastraH-Index: 18
Last. Francesco MigliavaccaH-Index: 60
view all 8 authors...
Abstract This study sought to investigate the possible influence of different bifurcation stenting techniques on stent deformation, physical stress, and drug elution using a virtual tool that includes structural, fluid dynamics and drug-eluting numerical models. A virtual bench test based on explicit dynamics modelling was used to simulate procedures on bifurcated coronary vessels performed according to three different stenting techniques: provisional side branch stenting, culotte, and Tryton-ba...
17 CitationsSource
#1M. Caputo (Polytechnic University of Milan)H-Index: 1
#2Claudio Chiastra (Polytechnic University of Milan)H-Index: 18
Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 28
view all 9 authors...
SUMMARY Computational models are used to study the combined effect of biomechanical and biochemical factors on coronary in-stent restenosis, which is a postoperative remodeling and regrowth pathology of the stented arteries. More precisely, we address numerical simulations, on the basis of Navier–Stokes and mass transport equations, to study the role of perturbed wall shear stresses and reduced oxygen concentration in a geometrical model reconstructed from a real porcine artery treated with a st...
23 CitationsSource
#1Elena Cutrì (Polytechnic University of Milan)H-Index: 7
#2Paolo Zunino (University of Pittsburgh)H-Index: 28
Last. Francesco Migliavacca (Polytechnic University of Milan)H-Index: 60
view all 5 authors...
The treatment of coronary bifurcation lesions represents a challenge for the interventional cardiologists due to the lower rate of procedural success and the higher risk of restenosis. The advent of drug-eluting stents (DES) has dramatically reduced restenosis and consequently the request for re-intervention. The aim of the present work is to provide further insight about the effectiveness of DES by means of a computational study that combines virtual stent implantation, fluid dynamics and drug ...
28 CitationsSource