Pedro Pereira
University of Porto
Binding siteInternal medicineRadiologySurgeryEnzymeChemistryMaterials scienceSerineThrombinEndoscopic retrograde cholangiopancreatographyEndoscopyHydrolaseActive siteProtein structureX-ray crystallographyGeneticsBiochemistryGeneral surgeryStereochemistryMedicineCrystallographyBiologyGastroenterology
261Publications
28H-index
2,876Citations
Publications 257
Newest
#2Pedro PereiraH-Index: 28
Last. Guilherme MacedoH-Index: 23
view all 23 authors...
Background and Aims Therapeutic endoscopy plays a critical role in the management of upper GI (UGI) postsurgical leaks. Data are scarce regarding clinical success and safety. Our aim was to evaluate the effectiveness of endoscopic therapy for UGI postsurgical leaks and associated adverse events (AEs) and to identify factors associated with successful endoscopic therapy and AE occurrence. Methods This was a retrospective, multicenter, international study of all patients who underwent endoscopic t...
1 CitationsSource
#1Maria Filipa PintoH-Index: 4
#2Antonio Baici (UZH: University of Zurich)H-Index: 42
Last. Pedro M. Martins (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 16
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Abstract Enzymatic assays are widely employed to characterize important allosteric and enzyme modulation effects. The high sensitivity of these assays can represent a serious problem if the occurrence of experimental errors surreptitiously affects the reliability of enzyme kinetics results. We have addressed this problem and found that hidden assay interferences can be unveiled by the graphical representation of progress curves in modified reaction coordinates. To render this analysis accessible...
1 CitationsSource
#1Daniel J Ford (USYD: University of Sydney)H-Index: 1
#2Nisharnthi M. Duggan (USYD: University of Sydney)
Last. Richard J. Payne (USYD: University of Sydney)H-Index: 48
view all 18 authors...
The contact system comprises a series of serine proteases that mediate procoagulant and proinflammatory activities via the intrinsic pathway of coagulation and the kallikrein-kinin system, respectively. Inhibition of Factor XIIa (FXIIa), an initiator of the contact system, has been demonstrated to lead to thrombo-protection and anti-inflammatory effects in animal models and serves as a potentially safer target for the development of antithrombotics. Herein, we describe the use of the Randomised ...
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#1F. PinaH-Index: 10
#2Ana Ferro (University of Porto)H-Index: 12
Last. Nuno Lunet (University of Porto)H-Index: 52
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PURPOSE New biomarkers may contribute to avoid unnecessary biopsies resulting from the suboptimal performance of prostate-specific antigen (PSA) testing. This study aimed to assess serum endoglin as a prostate cancer (PCa) diagnostic tool among biopsy candidates. METHODS A total of 262 consecutive patients referred for prostate biopsy based on abnormal digital rectal examination and/or elevated total PSA (tPSA) who had serum endoglin assessed by solid-phase enzyme-linked immunosorbent assay were...
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#1Pedro PereiraH-Index: 28
#2Ana L. SantosH-Index: 19
Last. Guilherme MacedoH-Index: 23
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Abstract Background and Aims Recent data support a role for endoscopic radiofrequency ablation (RFA) in unresectable cholangiocarcinoma by improving stent patency and overall survival. Methods We describe 3 patients with inoperable cholangiocarcinoma with jaundice and cholestasis who were recommended palliative chemotherapy. They underwent endoscopic retrograde cholangiopancreatography with single-operator cholangioscope and intraductal RFA. Results The procedures were performed without adverse ...
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#1Maria Filipa Pinto (University of Porto)H-Index: 4
#2Francisco Figueiredo (University of Porto)H-Index: 6
Last. Pedro M. Martins (University of Porto)H-Index: 16
view all 8 authors...
The throughput level currently reached by automatic liquid handling and assay monitoring techniques is expected to facilitate the discovery of new modulators of enzyme activity. Judicious and depen...
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#1Stijn M. Agten (USYD: University of Sydney)H-Index: 1
#2Emma E. Watson (USYD: University of Sydney)H-Index: 6
Last. Richard J. Payne (USYD: University of Sydney)H-Index: 48
view all 9 authors...
Blood feeding arthropods, such as leeches, ticks, flies and mosquitoes, provide a privileged source of peptidic anticoagulant molecules. These primarily operate through inhibition of the central coagulation protease thrombin by binding to the active site and either exosite I or exosite II. Herein, we describe the rational design of a novel class of trivalent thrombin inhibitors that simultaneously block both exosites as well as the active site. These engineered hybrids were synthesized using tan...
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#1Stijn M. Agten (UM: Maastricht University)H-Index: 1
#2Emma E. Watson (USYD: University of Sydney)H-Index: 6
Last. Richard J. Payne (USYD: University of Sydney)H-Index: 48
view all 9 authors...
Source
#1Stijn M. Agten (UM: Maastricht University)H-Index: 1
#2Emma E. Watson (USYD: University of Sydney)H-Index: 6
Last. Richard J. Payne (USYD: University of Sydney)H-Index: 48
view all 9 authors...
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#1Johnny Lisboa (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 6
#2Cassilda Pereira (IBMC: Instituto de Biologia Molecular e Celular)H-Index: 5
Last. Francisco García-del Portillo (CSIC: Spanish National Research Council)H-Index: 41
view all 13 authors...
ABSTRACT Peptidoglycan (PG) is a major component of the bacterial cell wall, forming a mesh-like structure enwrapping the bacteria that is essential for maintaining structural integrity and providing support for anchoring other components of the cell envelope. PG biogenesis is highly dynamic and requires multiple enzymes, including several hydrolases that cleave glycosidic or amide bonds in the PG. This work describes the structural and functional characterization of an NlpC/P60-containing pepti...
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