Christian Herder
University of Düsseldorf
Genome-wide association studyInternal medicineEndocrinologySingle-nucleotide polymorphismCohort studyImmunologyHazard ratioAdiponectinInflammationType 2 diabetesInsulin resistanceInsulinBody mass indexPopulationObesityGeneticsDiabetes mellitusMedicineCohortBiology
Publications 466
#1Maria Apostolopoulou (HHU: University of Düsseldorf)H-Index: 5
#2Lucia Mastrototaro (HHU: University of Düsseldorf)H-Index: 12
Last. Daniel F. Markgraf (HHU: University of Düsseldorf)H-Index: 14
view all 18 authors...
High-intensity interval training (HIIT) improves cardiorespiratory fitness (VO2max), but its impact on metabolism remains unclear. We hypothesized that 12-week HIIT increases insulin sensitivity in...
1 CitationsSource
#1Jana NanoH-Index: 17
#2Ben Schöttker (Heidelberg University)H-Index: 64
Last. Dietrich Rothenbacher (University of Ulm)H-Index: 90
view all 16 authors...
BACKGROUND Inflammatory processes have been implicated in the development of chronic kidney disease (CKD). We investigated the association of a large panel of inflammatory biomarkers reflecting aspects of immunity with kidney function and CKD incidence. METHODS We used data from two independent population-based studies, KORA F4 (discovery, n = 1,110, mean age 70.3 years, 48.7% male) and ESTHER (replication, n = 1,672, mean age 61.9 years, 43.6% male). Serum levels of biomarkers were measured usi...
#1Chaterina Sujana (LMU: Ludwig Maximilian University of Munich)H-Index: 1
#2Veikko Salomaa (National Institute for Health and Welfare)H-Index: 163
Last. Viktor Oskarsson (Umeå University)H-Index: 8
view all 20 authors...
OBJECTIVE null Natriuretic peptide (NP) concentrations are increased in cardiovascular diseases (CVDs) but are associated with a lower diabetes risk. We investigated associations of N-terminal pro-B-type NP (NT-proBNP) and midregional proatrial NP (MR-proANP) with incident type 2 diabetes stratified by the presence of CVD. null RESEARCH DESIGN AND METHODS null Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) Consortium, we included 45,477 participants with NT-pro...
#1Jacqueline M Ratter-Rieck (HHU: University of Düsseldorf)
#2Haifa Maalmi (HHU: University of Düsseldorf)H-Index: 6
Last. Michael Roden (HHU: University of Düsseldorf)H-Index: 99
view all 10 authors...
Frequencies of circulating immune cells are altered in those with type 1 and type 2 diabetes compared with healthy individuals and are associated with insulin sensitivity, glycemic control, and lipid levels. This study aimed to determine whether specific immune cell types are associated with novel diabetes subgroups. We analyzed automated white blood cell counts (n = 669) and flow cytometric data (n = 201) of participants in the German Diabetes Study with recent-onset (<1 year) diabetes, who wer...
#1Yuan Zhang (University of Gothenburg)H-Index: 5
#2Linda Johansson (Umeå University)H-Index: 4
Last. Solbritt Rantapää-Dahlqvist (Umeå University)H-Index: 67
view all 11 authors...
We recently reported that increased serum adiponectin was associated with rheumatoid arthritis (RA) risk in subjects with obesity. We hereby aim to determine if other adipokines associate with RA risk and if the association between adiponectin and RA is independent of other adipokines. Two nested-case control studies were performed in two different cohorts: 82 participants of the Swedish Obese Subjects (SOS) study who developed RA during follow-up matched with 410 controls, and 88 matched pairs ...
1 CitationsSource
(1) Background: The study aimed to investigate the role of subclinical inflammation on the association between diurnal cortisol patterns and glycaemia in an aged population. (2) Methods: Salivary cortisol, interleukin-6 (IL-6) and glycated haemoglobin (HbA1c) were analysed in a sample of 394 men and 364 women (mean age = 5 ± 6.3, 65–90 years). The ratio of morning after awakening and late-night cortisol was calculated as an indication of diurnal cortisol slope (DCS). Multivariable regression mod...
#2Rory P. WilsonH-Index: 72
Last. Pascal Schlosser (University of Freiburg)H-Index: 7
view all 37 authors...
BACKGROUND Studies on the relationship between renal function and the human plasma proteome have identified several potential biomarkers. However, investigations have been conducted largely in European populations, and causality of the associations between plasma proteins and kidney function has never been addressed. METHODS A cross-sectional study of 993 plasma proteins among 2,882 participants in four studies of European and admixed ancestries (KORA, INTERVAL, HUNT, QMDiab) identified trans-et...
1 CitationsSource
Aim To determine the 10-year cumulative incidence of high depressive symptoms in people with diagnosed and, in particular, previously undetected diabetes compared to those without diabetes in a population-based cohort study in Germany. Materials and Methods We included 2813 participants (52.9% men, mean age (SD) 58.9 (7.7) years, 7.1% diagnosed diabetes, 5.6% previously undetected diabetes) from the Heinz Nixdorf Recall study. We calculated the odds ratios (OR) with 95% confidence intervals (CI)...
#1Alina BauerH-Index: 1
#2Astrid ZiererH-Index: 17
Last. Cornelia HuthH-Index: 35
view all 16 authors...
It is still unclear how genetic information, provided as single-nucleotide polymorphisms (SNPs), can be most effectively integrated into risk prediction models for coronary heart disease (CHD) to add significant predictive value beyond clinical risk models. For the present study, a population-based case-cohort was used as a trainingset (451 incident cases, 1488 noncases) and an independent cohort as testset (160 incident cases, 2749 noncases). The following strategies to quantify genetic informa...
1 CitationsSource
#405Andrew P. Morris (University of Oxford)H-Index: 106
#406Inês Barroso (University of Exeter)H-Index: 109
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-ana...
5 CitationsSource