Todd W. Bauer
University of Virginia
CancerInternal medicineRadiologySurgeryOncologyResectionRetrospective cohort studyHazard ratioSurvival rateHepatectomyMetastasisSurgical oncologyPancreatic cancerIntrahepatic CholangiocarcinomaIn patientPerioperativeIncidence (epidemiology)Cancer researchMedicineCohortGastroenterology
150Publications
31H-index
4,133Citations
Publications 145
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#1Carlos Honrado (UVA: University of Virginia)H-Index: 7
#2Sara J. Adair (UVA: University of Virginia)H-Index: 11
Last. Nathan Swami (UVA: University of Virginia)H-Index: 28
view all 6 authors...
The ability to rapidly and sensitively predict drug response and toxicity using in vitro models of patient-derived tumors is essential for assessing chemotherapy efficacy. Currently, drug sensitivity assessment for solid tumors relies on imaging adherent cells or by flow cytometry of cells lifted from drug-treated cultures after fluorescent staining for apoptotic markers. Subcellular apoptotic bodies (ABs), including microvesicles that are secreted into the culture media under drug treatment can...
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#1Diamantis I. Tsilimigras (The Ohio State University Wexner Medical Center)H-Index: 21
#2Kota Sahara (The Ohio State University Wexner Medical Center)H-Index: 15
Last. Timothy M. Pawlik (The Ohio State University Wexner Medical Center)H-Index: 118
view all 21 authors...
BACKGROUND The objective of the current study was to develop a model to predict the likelihood of occult lymph node metastasis (LNM) prior to resection of intrahepatic cholangiocarcinoma (ICC). METHODS Patients who underwent hepatectomy for ICC between 2000 and 2017 were identified using a multi-institutional database. A novel model incorporating clinical and preoperative imaging data was developed to predict LNM. RESULTS Among 980 patients who underwent resection of ICC, 190 (19.4%) individuals...
1 CitationsSource
#1Guimin Dong (UVA: University of Virginia)
#2Mehdi Boukhechba (UVA: University of Virginia)H-Index: 8
Last. Philip I. Chow (UVA: University of Virginia)H-Index: 12
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Cortisol is a glucocorticoid hormone that is critical to immune system functioning. Studies show that prolonged exposure to high levels of cortisol can lead to a range of physical health ailments including the progression of tumor growth. The ability to monitor cortisol levels over time can therefore be used to facilitate decision-making during cancer treatment. However, collecting serum or saliva samples to monitor cortisol in situ is inconvenient, costly, and impractical. In this paper, we pro...
1 CitationsSource
#1Diamantis I. Tsilimigras (The Ohio State University Wexner Medical Center)H-Index: 21
#2J. Madison Hyer (The Ohio State University Wexner Medical Center)H-Index: 16
Last. Timothy M. Pawlik (The Ohio State University Wexner Medical Center)H-Index: 118
view all 23 authors...
INTRODUCTION While tumor burden (TB) has been associated with outcomes among patients with hepatocellular carcinoma, the role of overall TB in intrahepatic cholangiocarcinoma (ICC) remains poorly defined. METHODS Patients undergoing curative-intent resection of ICC between 2000 and 2017 were identified from a multi-institutional database. The impact of TB on overall (OS) and disease-free survival (DFS) was evaluated in the multi-institutional database and validated externally. RESULTS Among 1101...
7 CitationsSource
#1Xu-Feng Zhang (Xi'an Jiaotong University)H-Index: 10
#1Xu Feng Zhang (The Ohio State University Wexner Medical Center)H-Index: 11
Last. Timothy M. Pawlik (The Ohio State University Wexner Medical Center)H-Index: 118
view all 17 authors...
Abstract Background To improve the prognostic accuracy of the 8th edition of the American Joint Committee on Cancer (AJCC) staging system for intrahepatic cholangiocarcinoma (ICC) with establishment and validation of a modified TNM (mTNM) staging system. Methods Data of the patients who underwent curative-intent resection for ICC was collected from 15 high-volume centers worldwide (n=643). External validation dataset was obtained from the SEER registry (n=797). The mTNM staging system was propos...
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#1Robert H. Thiele (UVA: University of Virginia)H-Index: 24
#2Bethany M. Sarosiek (University of Virginia Health System)H-Index: 7
Last. Traci L. Hedrick (UVA: University of Virginia)H-Index: 28
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BACKGROUND Enhanced Recovery (ER) is a change management framework in which a multidisciplinary team of stakeholders utilizes evidence-based medicine to protocolize all aspects of a surgical care to allow more rapid return of function. While service-specific reports of ER adoption are common, institutional-wide adoption is complex, and reports of institution-wide ER adoption are lacking in the United States. We hypothesized that ER principles were generalizable across an institution and could be...
2 CitationsSource
#1Liangshuo Hu (Xi'an Jiaotong University)H-Index: 8
#2Xu-Feng Zhang (Xi'an Jiaotong University)H-Index: 10
Last. Timothy M. Pawlik (The Ohio State University Wexner Medical Center)H-Index: 118
view all 17 authors...
Objectives To assess conditional survival (CS) according to recurrence status, as well as conditional disease-free survival (cDFS) among patients with intrahepatic cholangiocarcinoma (ICC).
1 CitationsSource
#1William J. Kane (UVA: University of Virginia)H-Index: 3
#2Sara J. Adair (UVA: University of Virginia)H-Index: 11
Last. Todd W. Bauer (UVA: University of Virginia)H-Index: 31
view all 7 authors...
Purpose: The purpose of this study was to investigate protein arginine methyltransferase 5 (PRMT5) as a therapeutic target in combination with gemcitabine for pancreatic cancer in preclinical models. Procedures: In an orthotopic xenograft model, PRMT5 wild-type (WT) or knockout (KO) mPanc96 cells were injected into the pancreata of athymic nude mice. Mice were randomized to control or gemcitabine (100 mg/kg) arms. Tumor volume was measured with magnetic resonance imaging (MRI) at 21, 28, and 35 ...
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#1Xiaolong Wei (UVA: University of Virginia)H-Index: 2
#2Jiekun Yang (UVA: University of Virginia)H-Index: 8
Last. Mazhar Adli (UVA: University of Virginia)H-Index: 29
view all 15 authors...
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging cancers to treat. Due to the asymptomatic nature of the disease and lack of curative treatment modalities, the 5-y survival rate of PDAC patients is one of the lowest of any cancer type. The recurrent genetic alterations in PDAC are yet to be targeted. Therefore, identification of effective drug combinations is desperately needed. Here, we performed an in vivo CRISPR screen in an orthotopic patient-derived xenograft (PDX...
5 CitationsSource