Harold M. Burkhart
University of Oklahoma Health Sciences Center
Internal medicineRadiologySurgeryCardiologyRetrospective cohort studyAortic valve replacementArteryMitral valveHeart failureCardiac surgeryCardiopulmonary bypassTricuspid valveAortaHeart diseaseRegurgitation (circulation)Mitral valve repairAortic valveMitral regurgitationMedicineEjection fraction
280Publications
54H-index
5,405Citations
Publications 282
Newest
#1Rakesh M. Suri (Mayo Clinic)H-Index: 64
#2Amit Taggarse (Mayo Clinic)H-Index: 2
Last. Maurice Enriquez-Sarano (Mayo Clinic)H-Index: 110
view all 10 authors...
Background —Severe primary (degenerative) mitral valve regurgitation (MR) is repaired with durable results when "simple" single scallop disease is addressed. The mid-term quality outcomes of minimally invasive repair for "complex disease" are unknown however. Methods and Results —From January 2008 to January 2015, 487 patients (56±11 years, 360 men, ejection fraction 65±6%, 98.8% complete follow-up) underwent robotic mitral valve repair for severe non-ischemic degenerative MR. Simple pathology w...
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#1Matthew S. YongH-Index: 15
#2Pankaj SaxenaH-Index: 18
Last. Joseph F. MaloufH-Index: 26
view all 7 authors...
Transesophageal echocardiography continues to have a central role in the diagnosis of infective endocarditis and its sequelae. Recent technological advances offer the option of 3-dimensional imaging in the evaluation of patients with infective endocarditis. We present an illustrative case and review the literature regarding the potential advantages and limitations of 3-dimensional transesophageal echocardiography in the diagnosis of complicated infective endocarditis. A 51-year-old man, an intra...
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#1Harold M. Burkhart (University of Oklahoma Health Sciences Center)H-Index: 54
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ACQUIRED HEMOPHILIA A occurs as a result of development of inhibitory autoantibodies to factor VIII in the coagulation cascade. These antibodies result in impaired hemostasis and bleeding disorders of variable severities through varied mechanisms including impairment of binding of factor VIII to membrane phospholipids, factor IX, and/or von Willebrand factor. Common presentation includes mucocutaneous and soft tissue hemorrhage, although hemarthroses typically seen in severe congenital hemophili...
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#1Pankaj Saxena (Mayo Clinic)H-Index: 18
#2James R. Neal (Mayo Clinic)H-Index: 5
Last. Gregory J. Schears (Mayo Clinic)H-Index: 22
view all 13 authors...
Background We conducted a retrospective study to assess whether providing extracorporeal membrane oxygenation (ECMO) support to elderly patients (aged 70 years or more) who failed separation from cardiopulmonary bypass after cardiac surgery was a viable option. Methods From 2003 to 2013, 45 patients aged 70 years or more underwent 47 runs of ECMO postoperatively. Results There were 31 men (68.9%). The mean age was 76.8 years. Five patients were in cardiogenic shock preoperatively. Forty-four pat...
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#1Harold M. Burkhart (University of Oklahoma Health Sciences Center)H-Index: 54
#2Jess L. Thompson (University of Oklahoma Health Sciences Center)H-Index: 13
Last. Sabrina D. Phillips (University of Oklahoma Health Sciences Center)H-Index: 21
view all 3 authors...
Since the introduction of the Fontan operation over 4 decades ago, surgical and medical management strategies have evolved to improve outcomes and give hope to the patients with complex single ventricle anomalies. Unfortunately, along with these new treatment successes, another group of problems has become more evident stimulating us to rethink our current management with a new focus on long-term outcomes and quality of life. The primary detrimental physiologic conditions that Fontan operation i...
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#1Anna Sabate Rotes (Autonomous University of Barcelona)H-Index: 6
#2Jonathan N. Johnson (Mayo Clinic)H-Index: 31
Last. David J. Driscoll (Mayo Clinic)H-Index: 69
view all 6 authors...
Objective To describe and analyze the cardiopulmonary responses to exercise for patients with repaired tetralogy of Fallot (TOF) before and after pulmonary valve replacement (PVR) and compare our results with those in the literature. Methods Between 1973 and 2012, 278 patients had a first-time PVR after TOF repair. During their evaluations, 76 patients (27%) had exercise testing before PVR, and 63 (23%) had at least one test after PVR. There were 17 patients (average age at surgery 40 ± 14 years...
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#1Nassir M. Thalji (Mayo Clinic)H-Index: 10
#2Rakesh M. Suri (Mayo Clinic)H-Index: 64
Last. Hartzell V. Schaff (Mayo Clinic)H-Index: 132
view all 11 authors...
OBJECTIVES: Aortic valve replacement (AVR) for severe aortic valve stenosis (AS) is a Class I indication at the time of coronary artery bypass grafting (CABG). Management of less-than-severe AS in patients undergoing CABG is uncertain however, because the thresholds at which untreated AS impacts long-term outcome are unclear. METHODS: We identified 312 patients who underwent isolated CABG between 1993 and 2006 with mild or moderate AS [aortic valve area (AVA) 1– 2c m 2 ], and matched them to pat...
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#1Harold M. Burkhart (Mayo Clinic)H-Index: 54
#2Muhammad Yasir Qureshi (Mayo Clinic)H-Index: 12
Last. Timothy J. NelsonH-Index: 37
view all 7 authors...
The current standard of care for neonates with hypoplastic left heart syndrome (HLHS) includes a series of cardiac operations culminating in a complete cavopulmonary connection. Given the increased workload placed on the right ventricle, development of ventricular dysfunction and heart failure are concerns. As this patient population ages, many may require cardiac transplantation. Cellbased strategies to treat heart failure in adults have been reported, but little is known about their feasibilit...
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#1Anna Sabate Rotes (Autonomous University of Barcelona)H-Index: 6
#2Heidi M. Connolly (Mayo Clinic)H-Index: 75
Last. Christopher J. McLeod (Mayo Clinic)H-Index: 34
view all 11 authors...
Background— Most patients with repaired tetralogy of Fallot require pulmonary valve replacement (PVR), but the evaluation for and management of ventricular arrhythmia remain unclear. This study is aimed at clarifying the optimal approach to this potentially life-threatening issue at the time of PVR. Methods and Results— A retrospective analysis was performed on 205 patients with repaired tetralogy of Fallot undergoing PVR at our institution between 1988 and 2010. Median age was 32.9 (range, 25.6...
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