Toshiki Nakajima
Kyoto University
Internal medicineRadiologySNPCross-sectional studyPathologyUltrasoundSingle-nucleotide polymorphismAlleleImmunologyVasculitisInfliximabTocilizumabSystemic vasculitisRheumatoid arthritisUstekinumabDiseaseSynovitisIn patientTakayasu arteritisDisease activityMedicineComplicationGastroenterology
26Publications
8H-index
190Citations
Publications 26
Newest
#1Keiichiro Kadoba (Kyoto University)H-Index: 1
#2Ryu Watanabe (Kyoto University)H-Index: 19
Last. Masao Tanaka (Kyoto University)H-Index: 23
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HLA-B*52 is an established genetic factor in Takayasu arteritis (TAK). Recently, single nucleotide polymorphisms (SNPs) in IL12B (rs6871626) and LILRA3 (rs103294) were newly identified as non-HLA susceptibility loci in TAK. Here, we examined how these SNPs contribute to clinical characteristics and vascular damage in TAK. We retrospectively reviewed the medical records of 99 TAK patients enrolled in our previous genome-wide association study, and whose genotypes for IL12B rs6871626, LILRA3 rs103...
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#1Hidemasa Matsuo (Kyoto University)H-Index: 9
#2Yuya Tabuchi (Kyoto University)H-Index: 2
Last. Yasutomo Fujii (Kyoto University)H-Index: 4
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PURPOSE This study aimed to evaluate the positive rate and prognostic significance of superb microvascular imaging (SMI) in rheumatoid arthritis (RA) patients in remission with normal C-reactive protein (CRP) levels and erythrocyte sedimentation rates (ESR). METHODS The study enrolled 112 RA patients, and ultrasound (US) assessment was performed on 28 joints of each patient. RESULTS The SMI signal-positive rates for each joint were: metacarpophalangeal (MCP) joints: 20.5%, wrist joints: 43.8%, m...
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#1Yoshie Gon (Kyoto University)H-Index: 2
#2Hajime Yoshifuji (Kyoto University)H-Index: 23
Last. Chikashi Terao (Kyoto University)H-Index: 32
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Objectives: Biologics have been used to treat refractory Takayasu arteritis (TAK), but their efficacy and safety have not been sufficiently evaluated.Methods: We extracted clinical information from...
3 CitationsSource
#1Shinichiro Ishie (Kyoto University)H-Index: 1
#2Hiromu Ito (Kyoto University)H-Index: 51
Last. Shuichi Matsuda (Kyoto University)H-Index: 64
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OBJECTIVES We aimed to clarify the clinical implication of ultrasound (US)-detected foot joint inflammation in tightly controlled patients with rheumatoid arthritis (RA). METHODS We evaluated bilateral foot joints (second to fifth metatarsophalangeal joints of forefoot; tarsometatarsal, cuneonavicular and midtarsal joints of midfoot) of 430 RA patients for synovitis using Power Doppler (PD) imaging by US. We made a cross-sectional and a 3-year longitudinal analysis about the associations of US-d...
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#1Shuichiro Nakabo (Kyoto University)H-Index: 10
#2Yuko Tsuji (Kyoto University)H-Index: 2
Last. Yasutomo Fujii (Kyoto University)H-Index: 4
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OBJECTIVE: Although recent clinical trials showed that ultrasound (US) remission is not required to achieve good outcomes at the group level, it currently remains unclear whether the prognosis of individual patients in clinical remission, but not US remission, i.e., those with subclinical sonographic synovitis (SSS), is favorable. However, it is no longer acceptable to perform US on all patients in order to identify those with SSS. Therefore, the present study was initiated to elucidate the cond...
1 CitationsSource
#1Toshiki NakajimaH-Index: 8
#2Hajime YoshifujiH-Index: 2
Last. Tsuneyo MimoriH-Index: 1
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#1Toshiki NakajimaH-Index: 8
#2Hajime Yoshifuji (Kyoto University)H-Index: 23
Last. Chikashi Terao (University of Shizuoka)H-Index: 8
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Background: Relapsing polychondritis (RP) is a rare inflammatory disease, which is characterized by recurrent inflammation and destruction of cartilage tissues. RP also has the profile of autoimmune disease and is often complicated with other autoimmune disease. Autoimmune thyroid disease (AITD) is one of common autoimmune diseases, which consists of Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). While RP is reported to be complicated with AITD1), there has been no study on detailed prof...
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#1Rie Kawahara (Kyoto University)H-Index: 2
#2Shuichiro Nakabo (Kyoto University)H-Index: 10
Last. Yasutomo Fujii (Kyoto University)H-Index: 4
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AbstractObjective: Ultrasonography (US) is a useful tool for evaluating the activity of rheumatoid arthritis (RA) patients. As the systemic evaluation of many joints is time-consuming, a method to ...
1 CitationsSource
#1Hiroko Yamamoto (Kyoto University)H-Index: 2
#2Toshiki Nakajima (Kyoto University)H-Index: 8
Last. Yasutomo Fujii (Kyoto University)H-Index: 4
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AIM: Previous studies have reported that patients with rheumatoid arthritis (RA) have a higher risk of developing cardiovascular disease (CVD) than the general population. A major cause of CVD is atherosclerosis, which can be evaluated with carotid ultrasonography (US). As far as we know, there have been no large-scale carotid artery US studies in Japanese patients with RA. The aim of this study was to identify the risk factors for atherosclerosis in Japanese patients with RA. METHODS: The study...
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