Maria Marino
Istituto Superiore di Sanità
CancerEndocrinologyReceptorEstrogen receptor alphaChemistryApoptosisNeuroglobinEstrogenProgrammed cell deathCancer researchBiochemistryCell growthSignal transductionMedicineProtein kinase BEstrogen receptorBiologyCell biologyCancer cellEstrogen receptor beta
Publications 55
Reactive oxygen species (ROS) result from intracellular aerobic metabolism and/or extracellular stimuli. Although endogenous antioxidant systems exquisitely balance ROS production, an excess of ROS production, commonly found in diverse human degenerative pathologies including cancer, gives rise to the oxidative stress. Increased oxidative stress in cancer is related to the sustained proliferation and metabolism of cancer cells. However, cancer cells show an intrinsic higher antioxidant capacity ...
4 CitationsSource
: Here, we investigated the protein network regulating cholesterol metabolism in the liver and brain of adolescent and adult male and female rats prenatally exposed to valproate (VPA), a well validated experimental model of autism spectrum disorders (ASD). We were aimed at studying whether prenatal VPA exposure affected the proteins involved in cholesterol homeostasis in a sex-dependent manner. To this aim the protein network of cholesterol metabolism, in term of synthesis and plasma membrane tr...
6 CitationsSource
#1Marco FiocchettiH-Index: 12
#2Manuela CipollettiH-Index: 7
Last. Maria MarinoH-Index: 26
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: Neuroglobin (NGB) is a relatively recent discovered monomeric heme-protein, which behave in neurons as a sensor of injuring stimuli including oxidative stress, hypoxia, and neurotoxicity. In addition, the anti-apoptotic activity of overexpressed NGB has been reported both in neurons and in cancer cell lines. We recently demonstrated that, NGB functions as a compensatory protein of the steroid hormone 17β-estradiol (E2) protecting cancer cells against the apoptotic death induced by oxidative st...
9 CitationsSource
#1Marco FiocchettiH-Index: 12
#2Lucas A. Maddalena (Brock University)H-Index: 8
Last. Jeffrey A. Stuart (Brock University)H-Index: 29
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Oxidative stress and hypoxia play a central role in neuronal injury and cell death in acute and chronic pathological conditions. Neuroglobin (NGB) is a monomeric heme-protein found in neurons that, when overexpressed, confers resistance to apoptosis cause by oxidative stress, hypoxia, and neurotoxicity. Although NGB has been traditionally considered a cytoplasmic protein, recent findings indicate that NGB can localize to mitochondria. However, we have an incomplete understanding of the details o...
#1Daniele Marcoccia (ISS: Istituto Superiore di Sanità)H-Index: 7
#2Marco Pellegrini (UNIPD: University of Padua)H-Index: 8
Last. Maria MarinoH-Index: 26
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Androgens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood, androgens remain essential for the maintenance of male reproductive function and behavior. Androgens, acting through the androgen receptor (AR), regulate male sexual differentiation during development, sperm production beginning from puberty, and maintenance of prostate homeostasis. Sever...
9 CitationsSource
AbstractContext: Tumor acidity represents a major cause of chemoresistance. Proton pump inhibitors (PPIs) can neutralize tumor acidity, sensitizing cancer cells to chemotherapy.Objective: To compare the anti-tumor efficacy of different PPIs in vitro and in vivo.Materials and methods: In vitro experiments PPIs anti-tumor efficacy in terms of cell proliferation and cell death/apoptosis/necrosis evaluation were performed. In vivo PPIs efficacy experiments were carried out using melanoma xenograft m...
32 CitationsSource
AbstractContext: Proton Pump Inhibitors (PPIs) reduce tumor acidity and therefore resistance of tumors to drugs. Carbonic Anhydrase IX (CA IX) inhibitors have proven to be effective against tumors, while tumor acidity might impair their full effectiveness.Objective: To analyze the effect of PPI/CA IX inhibitors combined treatment against human melanoma cells.Methods: The combination of Lansoprazole (LAN) and CA IX inhibitors (FC9-399A and S4) has been investigated in terms of cell proliferation ...
35 CitationsSource
#1Pierangela TottaH-Index: 16
#2Claudia BusoneroH-Index: 8
Last. Filippo AcconciaH-Index: 30
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17β-estradiol (E2) regulates diverse physiological effects, including cell proliferation, by binding to estrogen receptor α (ERα). ERα is both a transcription factor that drives E2-sensitive gene expression and an extra-nuclear localized receptor that triggers the activation of diverse kinase cascades. While E2 triggers cell proliferation, it also induces ERα degradation in a typical hormone-dependent feedback loop. Although ERα breakdown proceeds through the 26S proteasome, a role for lysosomes...
21 CitationsSource
#1Valeria PesiriH-Index: 7
#2Pierangela TottaH-Index: 16
Last. Filippo AcconciaH-Index: 30
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Abstract 17β-Estradiol (E2)-dependent cell proliferation requires both estrogen receptor α (ERα)-based integrated control of gene transcription and kinase pathways activation. Such coordination of intracellular E2:ERα-dependent signaling mechanisms is finely tuned by receptor association with specific partner proteins. Recently, we identified the leucine (L) 429 and alanine (A) 430 within the ERα ligand binding domain as important residues for receptor non-covalent interaction to ubiquitinated s...
13 CitationsSource
#1Paolo AscenziH-Index: 49
#2Massimo ColettaH-Index: 33
Last. Roberto SantucciH-Index: 26
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Cytochrome c (cytc) is a small heme-protein located in the space between the inner and the outer membrane of the mitochondrion that transfers electrons from cytc-reductase to cytc-oxidase. The hexa-coordinated heme-Fe atom of cytc displays a very low reactivity toward ligands and does not exhibit significant catalytic properties. However, upon cardiolipin (CL) binding, cytc achieves ligand binding and catalytic properties reminiscent of those of myoglobin and peroxidase. In particular, the perox...
30 CitationsSource
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