Eleonora Petito
University of Perugia
Matrix metalloproteinaseInternal medicineEndocrinologyChemistryIn vitroImmunologyIn vivoOsteoarthritisSynovial fluidInflammationHyaluronic acidTenofovirAbacavirCartilageThrombosisEndothelial dysfunctionThrombusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Human immunodeficiency virus (HIV)In patientPlatelet activationChemotaxisMedicinePlateletGastroenterologyPharmacology
18Publications
7H-index
118Citations
Publications 18
Newest
#1Emanuela Falcinelli (University of Perugia)H-Index: 24
#2Eleonora Petito (University of Perugia)H-Index: 7
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2 CitationsSource
#1Paolo Gresele (University of Perugia)H-Index: 69
#2Emanuela Falcinelli (University of Perugia)H-Index: 24
Last. Manuela Sebastiano (University of Perugia)H-Index: 6
view all 5 authors...
Platelets contain and release several matrix metalloproteinases (MMPs), a highly conserved protein family with multiple functions in organism defense and repair. Platelet-released MMPs as well as MMPs generated by other cells within the cardiovascular system modulate platelet function in health and disease. In particular, a normal hemostatic platelet response to vessel wall injury may be transformed into pathological thrombus formation by platelet-released and/or by locally generated MMPs. Howev...
1 CitationsSource
#1Eleonora Petito (University of Perugia)H-Index: 7
#2Emanuela Falcinelli (University of Perugia)H-Index: 24
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BACKGROUND: SARS-CoV-2 infection is associated with hypercoagulability which predisposes to venous thromboembolism (VTE).We analyzed platelet and neutrophil activation in COVID-19 patients and their association with VTE. METHODS: Hospitalized COVID-19 patients and age- and sex-matched healthy controls were studied. Platelet and leukocyte activation, neutrophil extracellular traps (NETs), and matrix metalloproteinase-9 (MMP-9), a neutrophil-released enzyme, were measured. Four patients were re-st...
5 CitationsSource
#1Loredana Bury (University of Perugia)H-Index: 16
#2Barbara Camilloni (University of Perugia)H-Index: 12
Last. Paolo Gresele (University of Perugia)H-Index: 69
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The frequent finding of thrombocytopenia in patients with severe SARS-CoV-2 infection (COVID-19) and previous evidence that several viruses enter platelets suggest that SARS-CoV-2 might be internalized by platelets of COVID-19. Aim of our study was to assess the presence of SARS-CoV-2 RNA in platelets from hospitalized patients with aconfirmed diagnosis of COVID-19. RNA was extracted from platelets, leukocytes and serum from 24 COVID-19 patients and 3 healthy controls, real-time PCR and ddPCR fo...
2 CitationsSource
#1Emanuela Falcinelli (University of Perugia)H-Index: 24
#2Nicola GiordanH-Index: 7
Last. Roberto Gerli (University of Perugia)H-Index: 67
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Source
#1Loredana Bury (University of Perugia)H-Index: 16
#2Alessandro Malara (UNIPV: University of Pavia)H-Index: 17
Last. Paolo Gresele (University of Perugia)H-Index: 69
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Platelet-type von Willebrand disease is an inherited platelet disorder characterized by thrombocytopenia with large platelets caused by gain-of-function variants in GP1BA leading to enhanced GPIbα von Willebrand factor interaction. GPIbα and von Willebrand factor play a role in megakaryocytopoiesis, thus we aimed to investigate megakaryocyte differentiation and proplatelet-formation in platelet-type von Willebrand disease using megakaryocytes from a patient carrying the Met239Val variant and fro...
14 CitationsSource
#1Eleonora Petito (University of Perugia)H-Index: 7
#2Richard T. Amison ('KCL': King's College London)H-Index: 9
Last. Clive P. Page ('KCL': King's College London)H-Index: 86
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Abstract Introduction Platelets participate in inflammatory disorders through a variety of different functional responses, including chemotaxis, platelet-leukocyte complex formation and facilitation of leukocyte recruitment that are thought to be distinct from platelet aggregation. This may account for why classical anti-platelet drugs have failed to ameliorate inflammatory disorders where platelets are known to participate, suggesting that distinct pathways may control inflammatory and haemosta...
6 CitationsSource
#1Alessia Alunno (University of Perugia)H-Index: 34
#2Emanuela Falcinelli (University of Perugia)H-Index: 24
Last. Paolo Gresele (University of Perugia)H-Index: 69
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Inflammation plays a role in the initiation and progression of osteoarthritis (OA), a chronic degenerative joint disorder. Platelets are inflammatory cells, contain and release matrix metalloproteinases (MMPs) and favour the release of these enzymes, key effectors of cartilage and subchondral bone degradation, by other cells; however, their role in OA has not been investigated yet. Our aims were (1) to assess the presence of platelets and of MMP-2 in synovial fluid (SF) of OA patients; (2) to ev...
13 CitationsSource
#1Emanuela FalcinelliH-Index: 24
#2Benilde CosmiH-Index: 42
Last. Paolo GreseleH-Index: 69
view all 10 authors...
1 CitationsSource
#1Eleonora Petito (University of Perugia)H-Index: 7
#2Stefania Momi (University of Perugia)H-Index: 29
Last. Paolo Gresele (University of Perugia)H-Index: 69
view all 3 authors...
Platelets, beyond their well-described role in haemostasis and thrombosis, act as inflammatory cells playing an active role in several inflammatory conditions. As observed with other inflammatory cells platelets can migrate in vitro, either randomly or in the direction of a chemotactic agent, and in vivo, into inflammed tissues in response to different stimuli. In this chapter we will summarize the current knowledge about the mechanisms that regulate platelet chemotaxis, the evidence for the abi...
5 CitationsSource