Donald J. Hagler
University of California, San Diego
AnatomyInternal medicineRadiologySurgeryMagnetic resonance imagingDiffusion MRIPsychologyCardiologyNeuroscienceCognitionHemodynamicsCardiac catheterizationVentricleHeart diseasePercutaneousPulmonary arteryTemporal lobeWhite matterBrain mappingMagnetoencephalographyNeuroimagingMedicineBiology
Publications 441
#1Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
#2Christine Fennema-Notestine (UCSD: University of California, San Diego)H-Index: 56
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 71
view all 11 authors...
Author(s): McEvoy, LK; Fennema-Notestine, C; Elman, JA; Eyler, LT; Franz, CE; Jr, HDJ; Hatton, SN; Lyons, MJ; Panizzon, MS; Dale, AM; Kremen, WS | Abstract: Heavy alcohol consumption is associated with deleterious changes in the brain but associations of moderate alcohol intake are not well understood. We examined the association of alcohol consumption with brain white matter health in 377 middle-aged men (56-66 years old; mean 61.8 ± 2.6 years) who were participants in the Vietnam Era Twin Stud...
10 CitationsSource
#1Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 71
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Pupillary responses during cognitive tasks are linked to functioning of the locus coeruleus (LC). The LC is an early site of abnormal tau deposition, which may contribute to key aspects of Alzheimer's disease (AD) pathophysiology. We previously found attenuation of pupillary responses to increases in cognitive load in individuals with mild cognitive impairment (MCI), suggesting pupillary responses may provide a biomarker of early risk for AD associated with LC dysfunction. The LC modulates corti...
19 CitationsSource
#1William R. Miranda (Mayo Clinic)H-Index: 16
#2Alexander C. Egbe (Mayo Clinic)H-Index: 19
Last. Carole A. Warnes (Mayo Clinic)H-Index: 71
view all 7 authors...
Abstract Background Pulmonary artery wedge pressure (PAWP) has been shown to correlate better with left atrial pressure (LAP) than ventricular end-diastolic pressure (VEDP) in acquired heart disease. The correlation between VEDP and PAWP and their performance as surrogates for LAP in Fontan patients is unknown. Methods Offline single-beat simultaneous measurement of PAWP and VEDP was performed in 50 adult Fontan patients and non-simultaneous hemodynamic data abstracted for calculation of pulmona...
7 CitationsSource
#1Mohamad Alkhouli (WVU: West Virginia University)H-Index: 23
#2Chad J. Zack (Mayo Clinic)H-Index: 12
Last. Charanjit S. RihalH-Index: 35
view all 10 authors...
Background— Percutaneous closure of prosthetic mitral valve paravalvular leak (PVL) has emerged as an alternative to surgical treatment in high-risk patients. Limited data exist on the impact of successful percutaneous PVL closure on midterm outcomes. Methods and Results— We examined consecutive patients who underwent percutaneous mitral PVL closure at Mayo Clinic, Rochester, MN, between January 2006 and January 2017. Procedural success, in-hospital outcomes, and midterm mortality were assessed....
18 CitationsSource
#1Alexander C. Egbe (Mayo Clinic)H-Index: 19
#2Heidi M. Connolly (Cincinnati Children's Hospital Medical Center)H-Index: 74
Last. Barry A. Borlaug (Cincinnati Children's Hospital Medical Center)H-Index: 77
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Background Nonpulsatile pulmonary blood flow in Fontan circulation results in pulmonary vascular disease, but the potential relationships between pulmonary vascular resistance index (PVRI) and Fontan failure have not been studied. The objective was to determine whether the absence of subpulmonary ventricle in the Fontan circulation would make patients more vulnerable to even low-level elevations in PVRI, and when coupled with low cardiac index, this would identify patients at increased risk of F...
36 CitationsSource
#1Talha Niaz (Mayo Clinic)H-Index: 8
#2Joseph T. Poterucha (Mayo Clinic)H-Index: 17
Last. Donald J. Hagler (Mayo Clinic)H-Index: 89
view all 9 authors...
Background In patients with bicuspid aortic valve (BAV), complications including progressive aortic stenosis and aortic dilatation develop over time. The morphology of cusp fusion is one of the determinants of the type and severity of these complications. We present the association of morphology of cusp fusion in BAV patients with distinctive genetic syndromes. Methods The Mayo Clinic echocardiography database was retrospectively reviewed to identify patients (age ≤ 22 years) diagnosed with BAV ...
11 CitationsSource
#1Mohamad Alkhouli (WVU: West Virginia University)H-Index: 23
#2Charanjit S. Rihal (Mayo Clinic)H-Index: 96
Last. Sameh M. Said (Mayo Clinic)H-Index: 22
view all 13 authors...
Abstract Objectives The aim of this study was to report the use trends and immediate and long-term outcomes of a large cohort of patients who underwent redo surgery or transcatheter repair of paravalvular leaks (PVLs) at a tertiary referral center. Background Percutaneous treatment of mitral PVL has emerged as an alternative to surgical treatment in high-risk surgical candidates. There are limited data on the utilization trends, safety, and efficacy of both procedures in the management of mitral...
34 CitationsSource
1 CitationsSource
#1Muhammad Yasir Qureshi (Mayo Clinic)H-Index: 10
#2Allison K. Cabalka (Mayo Clinic)H-Index: 30
Last. Karen MillerH-Index: 2
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Abstract Myocardial dysfunction after Fontan palliation for univentricular congenital heart disease is a challenging clinical problem. The medical treatment has a limited impact, with cardiac transplant being the ultimate management step. Cell-based therapies are evolving as a new treatment for heart failure. Phase 1 clinical trials using regenerative therapeutic strategies in congenital heart disease are ongoing. We report the first case of autologous bone marrow–derived mononuclear cell admini...
4 CitationsSource
#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 11
#2Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 89
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 14 authors...
Background Diffusion imaging has demonstrated sensitivity to structural brain changes in Alzheimer’s disease (AD). However, there remains a need for a more complete characterization of microstructural alterations occurring at the earliest disease stages, and how these changes relate to underlying neuropathology. This study evaluated the sensitivity of restriction spectrum imaging (RSI), an advanced diffusion magnetic resonance imaging (MRI) technique, to microstructural brain changes in mild cog...
10 CitationsSource