Donald J. Hagler
University of California, San Diego
AnatomyInternal medicineRadiologySurgeryMagnetic resonance imagingDiffusion MRIPsychologyCardiologyNeuroscienceCognitionHemodynamicsCardiac catheterizationVentricleHeart diseasePercutaneousPulmonary arteryTemporal lobeWhite matterBrain mappingMagnetoencephalographyNeuroimagingMedicineBiology
457Publications
89H-index
20.3kCitations
Publications 441
Newest
#1Young Erben (Yale University)H-Index: 15
#2Gustavo S. Oderich (Mayo Clinic)H-Index: 54
Last. Donald J. Hagler (Mayo Clinic)H-Index: 89
view all 16 authors...
Abstract Objective The objective of this study was to evaluate outcomes of endovascular treatment of aortic coarctation in adults. Methods Clinical data and imaging studies of 93 consecutive patients treated at nine institutions from 1999 to 2015 were reviewed. We included newly diagnosed aortic coarctation (NCO), recurrent coarctation, and aneurysmal/pseudoaneurysmal degeneration (ANE) after prior open surgical repair (OSR) of coarctation. Primary end points were morbidity and mortality. Second...
12 CitationsSource
#1William S. Kremen (UCSD: University of California, San Diego)H-Index: 71
#2Asad Beck (SDSU: San Diego State University)H-Index: 5
Last. Carol E. Franz (UCSD: University of California, San Diego)H-Index: 49
view all 16 authors...
How and when education improves cognitive capacity is an issue of profound societal importance. Education and later-life education-related factors, such as occupational complexity and engagement in cognitive-intellectual activities, are frequently considered indices of cognitive reserve, but whether their effects are truly causal remains unclear. In this study, after accounting for general cognitive ability (GCA) at an average age of 20 y, additional education, occupational complexity, or engage...
31 CitationsSource
#1Daniel E. Gustavson (UCSD: University of California, San Diego)H-Index: 16
#2Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 22
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 71
view all 14 authors...
Abstract Individual differences in white matter tract microstructure, measured with diffusion tensor imaging (DTI), demonstrate substantial heritability. However, it is unclear to what extent this heritability reflects global genetic influences or tract-specific genetic influences. The goal of the current study was to quantify the proportion of genetic and environmental variance in white matter tracts attributable to global versus tract-specific influences. We assessed fractional anisotropy (FA)...
10 CitationsSource
#1Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
#2Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 71
view all 16 authors...
BACKGROUND: Large-scale brain networks such as the default mode network (DMN) are often disrupted in Alzheimer's disease (AD). Numerous studies have examined DMN functional connectivity in those with mild cognitive impairment (MCI), a presumed AD precursor, to discover a biomarker of AD risk. Prior reviews were qualitative or limited in scope or approach. OBJECTIVE: We aimed to systematically and quantitatively review DMN resting state fMRI studies comparing MCI and healthy comparison (HC) group...
16 CitationsSource
#1Talha Niaz (Mayo Clinic)H-Index: 8
#2Donald J. Hagler (Mayo Clinic)H-Index: 89
Bicuspid aortic valve (BAV) is one of the most common congenital heart defects leading to a significant global financial health burden as a result of its complications (1). BAV can lead to premature aortic valve disease in the form of aortic valve stenosis or regurgitation requiring multitude of interventions on aortic valve, including transcatheter interventions or surgical valve replacement. BAV disease is a continuum of disease process that not only affects the aortic valve but also extends t...
3 CitationsSource
#1Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 89
#2Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 22
Last. Anders M. Dale (UC: University of California)H-Index: 165
view all 142 authors...
The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects of environmental influences on behavioral and brain development in adolescents. The ABCD Study is a collaborative effort, including a Coordinating Center, 21 data acquisition sites across the United States, and a Data Analysis and Informatics Center (DAIC). The main objective of the study is to recruit and assess over eleven thousand 9-10-year-olds and follow them over the course of 10 years to...
21 CitationsSource
#1Natacha Akshoomoff (UCSD: University of California, San Diego)H-Index: 46
#2Timothy T. Brown (UCSD: University of California, San Diego)H-Index: 33
Last. Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 89
view all 4 authors...
Author(s): Akshoomoff, Natacha; Brown, Timothy T; Bakeman, Roger; Hagler, Donald J | Abstract: The NIH Toolbox Cognition Battery (NTCB) is a brief computerized method for evaluating neuropsychological functions in children, adolescents, and adults. We examined how performance on the 2 executive function measures of cognitive flexibility and inhibitory control was related to performance on the other NTCB measures across development.Participants were 1,020 typically developing individuals between ...
9 CitationsSource
#1B. J. Casey (Yale University)H-Index: 108
#2Tariq Cannonier (Yale University)H-Index: 1
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 165
view all 34 authors...
Abstract The ABCD study is recruiting and following the brain development and health of over 10,000 9–10 year olds through adolescence. The imaging component of the study was developed by the ABCD Data Analysis and Informatics Center (DAIC) and the ABCD Imaging Acquisition Workgroup. Imaging methods and assessments were selected, optimized and harmonized across all 21 sites to measure brain structure and function relevant to adolescent development and addiction. This article provides an overview...
374 CitationsSource
#1Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 22
#2Carol E. Franz (UCSD: University of California, San Diego)H-Index: 49
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 71
view all 11 authors...
Abstract Negative fateful life events (FLEs) such as interpersonal conflict, death in the family, financial hardship, and serious medical emergencies can act as allostatic stressors that accelerate biological aging. However, the relationship between FLEs and neuroanatomical aging is not well understood. We examined 359 men (mean age 62 years) participating in the Vietnam Era twin study of aging (VETSA) to determine whether negative midlife FLEs are associated with advanced brain aging after cont...
13 CitationsSource
#1Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
#2Andrew J. SchorkH-Index: 35
Last. Eric Halgren (UCSD: University of California, San Diego)H-Index: 90
view all 16 authors...
Despite great interest in using magnetic resonance imaging (MRI) for studying the effects of genes on brain structure in humans, current approaches have focused almost entirely on predefined regions of interest and had limited success. Here, we used multivariate methods to define a single neuroanatomical score of how William’s Syndrome (WS) brains deviate structurally from controls. The score is trained and validated on measures of T1 structural brain imaging in two WS cohorts (training, n = 38;...
3 CitationsSource